Table 5.

Reported TEN cases associated with lamotrigine

Study Type	Number of Cases	Key Findings	References
Case Reports	≥ 50 cases	TEN typically occurs within 2–8 weeks of drug initiation, often linked to rapid dose escalation.	[15, 27–35]
Multicenter Cohort Study	12 cases	Lamotrigine accounts for 5.3% of all drug-induced TEN cases, with a mortality rate of approximately 30% (SCORTEN-dependent).	[31, 33, 36]
Asian Population Studies	23 cases	HLA-B*15:02 carriers have an 80-fold increased risk, underscoring the need for genetic screening before lamotrigine initiation.	[33, 36]
Meta-analysis	7 studies	Risk of lamotrigine-induced TEN estimated at 1/1000 to 1/5000, significantly higher than that of other new-generation AEDs.	[16, 23, 35]