Table 6.
Clinical characteristics of previously reported cases of lamotrigine-induced TEN
| Study | Age/sex | Lamotrigine Dosage | Onset (Days) | Mucosal Involvement |
Treatment | Outcome |
|---|---|---|---|---|---|---|
|
Sullivan JR et al. [37], 1996 |
29/F |
25 mg alternate nights |
9 | Oral, genital | Cyclosporine (4.5 mg/kg/d) | Cured |
|
Fernández CalvoC et al. [38], 2000 |
44/F | N/A | 42 | N/A | GC | Cured |
|
Tristani-FirouziP et al. [39], 2002 |
14/F | N/A | N/A | N/A | IVIG | Cured |
|
Sladden M et al. [40], 2004 |
26/F |
25 mg alternate days |
14 | Oral, genital | Supportive therapy | Cured |
|
ChangCC et al. [41], 2005 |
32/F | 12.5 mg/d | 14 | N/A | MP | Cured |
|
Rodríguez-BlancoI et al. [42], 2005 |
37/M | 50 mg/d | 3 | N/A | PD | Cured |
|
VargheeSP et al. [43], 2006 |
14/F | 25 mg/d | 21 | N/A | MP | Cured |
| 28/F | 25 mg/d | 18 | N/A | MP | Cured | |
| 14/F | 50 mg/d | 21 | N/A | MP | Cured | |
|
DuparA et al. [44], 2010 |
16/F | N/A | 15 | oral | N/A | Cured |
|
Fayaz A et al. [45], 2011 |
20/F | 200 mg/d | 18 | Oral | Intravenous dexamethasone for 3 days | Cured |
|
Kazeem et al. [26], 2009 |
37/F |
12.5 mg/d With valproic acid1050 mg |
21 | Oral, ocular | steroid hormone 1000 mg/d | Died |
|
Kazee et al. [26], 2009 |
19/F | 100 mg/d | 14 | Oral, ocular |
0.5 mg/kg/d of IgM-IVIG |
Cured |
|
HaoxiangX et al. [46], 2009 |
72/F | 75 mg/d | N/A | N/A | IVIG + MP | Cured |
|
HaoxiangX et al. [46], 2009 |
35/F | 50 mg/d | 10 | N/A | Corticosteroids | Cured |
|
HuangHT et al. [47], 2010 |
30/M | 30 mg/d | 19 | N/A | Antibiotics | Cured |
|
BarvaliyaMJ et al. [48], 2012 |
12/M | 50 mg/d | 28 | N/A | Steroids | Died |
|
KaurSKad DograA [49], 2013 |
47/F | 100 mg/d | 12 | N/A | PD | Cured |
| 26/F | N/A | 28 | N/A | PD | Uneventful Recovery | |
|
Russomanno et al. [50], 2021 |
22/F | N/A | 14 | Oral, ocular | Cyclosporine×5d | Cured |
|
Lindsey J et al. [51], 2022 |
29/F | Lamotrigine (L) and TMP-SMX | 17 |
Oral, ocular, esophagel, genital |
Cyclosporine×14 d | Cured |
| Current case | 33/F | Lamotrigine 25 mg/d, oxcarbazepine 75 mg/d and topiramate 100 mg/d | 9 | Oral, ocular | dexamethasone combined with IVIG etc. | Cured |
Abbreviations: TEN: Toxic Epidermal Necrolysis; F: female; M: male; d: day; GC: glucocorticoid; IVIG: intravenous immunoglobulin; NOS: not otherwise specified; N/A: not applicable; TMP-SMX: trimethoprim-sulfamethoxazole; PD: prednisone; MP: methylprednisolone; Onset: Time from Drug Exposure to Rash Onset