Table 2.

Overview of the three sub-models with their corresponding features and algorithms.

Sub model	Algorithm	Features
Single-Type SBF	ResNet34	Amino acid composition, AAindex encoding, and one-hot encoding
Co-Type SBF	ResNet34	K-mer alongside amino acid composition, AAindex encoding, and one-hot encoding
S-FBF	XGBoost	Secondary structure, relative solvent accessibility/absolute solvent-accessible area, and signal peptide cleavage site features.