Table 1.

This table presents the values for each parameter included in the Markov model. For probabilistic modeling, both utilities and costs were modeled using a truncated gamma distribution. While the hazard ratios were kept constant, the event transition probabilities were modeled using a beta distribution as reported in Fig. 2.

Parameter	Deterministic value	Lower Bound	Upper bound	Source
Utilities
CABG	1	–	–	https://pubmed.ncbi.nlm.nih.gov/28097904/
MI	0.824	0.800	0.848	https://pubmed.ncbi.nlm.nih.gov/28097904/
Stroke	0.524	0.472	0.576	https://pubmed.ncbi.nlm.nih.gov/28097904/
Reintervention	0.824	0.800	0.848	https://pubmed.ncbi.nlm.nih.gov/28097904/
Dead	0	0	0	https://pubmed.ncbi.nlm.nih.gov/26172894/
CABG	4817	–	–	https://pubmed.ncbi.nlm.nih.gov/9605051/
Cost (US Dollars)
MI (Long Term)	8096	7495	8697	https://pubmed.ncbi.nlm.nih.gov/28097904/
MI (Acute Event)	49,604	48,247	50,962	https://pubmed.ncbi.nlm.nih.gov/28097904/
Stroke (Long Term)	8396	7212	9579	https://pubmed.ncbi.nlm.nih.gov/28097904/
Stroke (Acute Event)	44,007	41,965	46,049	https://pubmed.ncbi.nlm.nih.gov/28097904/
Reintervention (Long Term)	8096	7495	8697	https://pubmed.ncbi.nlm.nih.gov/28097904/
Reintervention (Acute Event)	80,000	64,000	92,000	https://pubmed.ncbi.nlm.nih.gov/31461121/
End of life care	72,892	71,814	73,970	https://pmc.ncbi.nlm.nih.gov/articles/PMC9904126/
Annual Colchicine Cost	2766.7	–	–
Annual Pneumonia Cost	13,705	13,526	13,883	https://pubmed.ncbi.nlm.nih.gov/30217156/
Physician Visit Cost	77.6	58.2	97	https://pmc.ncbi.nlm.nih.gov/articles/PMC6714024/
Hazard ratio (current secondary preventive therapy + Colchicine vs current secondary preventive therapy)
MI	0.64	–	–	https://pubmed.ncbi.nlm.nih.gov/34369166/
Reintervention	0.61	–	–	https://pubmed.ncbi.nlm.nih.gov/34369166/
Stroke	0.50	–	–	https://pubmed.ncbi.nlm.nih.gov/34369166/
Death	0.96	–	–	https://pubmed.ncbi.nlm.nih.gov/34369166/