Summary
Background
Metformin is a widely used anti-diabetic drug. Several studies have suggested that metformin has anticancer activity in some malignancies, including prostate cancer. Metformin might also mitigate the adverse metabolic effects of androgen-deprivation therapy (ADT). We hypothesised that metformin might improve survival in patients with metastatic hormone-sensitive prostate cancer and reduce metabolic complications associated with ADT.
Methods
The STAMPEDE multi-arm, multi-stage, randomised phase 3 trial recruited patients with high-risk locally advanced or metastatic adenocarcinoma of the prostate staged by conventional imaging with isotope bone and CT scanning. This publication reports findings for the most recent STAMPEDE research question, testing the addition of metformin to standard of care for non-diabetic (glycated haemoglobin [HbA1c] <48 mmol/mol [equivalent to <6·5%]) patients with metastatic disease with adequate renal function (glomerular filtration rate ≥45 ml/min/1·73 m2) and WHO performance status 0–2. This trial recruited from 112 hospitals in the UK and Switzerland to the STAMPEDE protocol. Patients were randomly allocated (1:1) to standard of care or standard of care plus metformin 850 mg twice daily. Random assignment was by telephone using minimisation with a random element of 20% (developed and maintained by the MRC Clinical Trials Unit at UCL), stratified for randomising hospital, age (<70 years vs ≥70 years), WHO performance status (0 vs 1 or 2), type of ADT, regular long-term use of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs; yes vs no), pelvic nodal status (positive vs negative), planned radiotherapy (yes vs no), and planned docetaxel or androgen receptor pathway inhibitor (ARPI) use (docetaxel vs abiraterone, enzalutamide, or apalutamide vs none). Standard of care comprised ADT with or without radiotherapy and with or without docetaxel or ARPI. The primary outcome measure was overall survival, defined as the time to death from any cause, assessed in the intention-to-treat population. Safety was assessed in patients who started treatment. The trial is registered with ClinicalTrials.gov, NCT00268476 and ISRCTN, ISRCTN78818544.
Findings
Between Sep 5, 2016, and Mar 31, 2023, 1874 patients with metastatic disease were randomly allocated to standard of care (n=938) or standard of care plus metformin (n=936). The median patient age was 69 years (IQR 63-73) and the median PSA was 84 ng/mL (24–352). 1758 (94%) of 1874 patients were newly diagnosed with metastatic disease and 116 (6%) were diagnosed with metachronous relapsing disease. 1543 (82%) of 1874 patients received ADT plus docetaxel and 52 (3%) received abiraterone, enzalutamide, or apalutamide. The median time to most recent case report form follow-up was 60 months (IQR 49–72). 473 deaths were reported in the standard of care group; median survival was 61·8 months (IQR 29·7 to not reached). There were 453 deaths in the metformin group; median survival was 67·4 months (32·5 to not reached; HR 0·91, 95% CI 0·80–1·03; p=0·15). Grade 3 or worse adverse events were reported in 487 (52%) of 938 patients in the standard of care group and 523 (57%) of 921 patients in the standard of care plus metformin group. 61 (7%) patients in the standard of care group and 84 (9%) patients in the standard of care plus metformin group reported at least one grade 3 or worse gastrointestinal adverse event; all other body systems showed no difference in grade 3 adverse events. There were six drug-related deaths in the standard of care group and one in the standard of care plus metformin group.
Interpretation
We did not find significant evidence of an overall survival benefit of adding metformin to standard of care in the overall population of patients with metastatic hormone-sensitive prostate cancer. The side-effect profile of metformin was as expected and consisted mainly of diarrhoea. Adverse metabolic side-effects of ADT were significantly reduced in the metformin group compared with the standard of care group.
Funding
Cancer Research UK, Prostate Cancer UK, and UK Research and Innovation Medical Research Council.
Introduction
Combination therapies have improved outcomes for patients with metastatic hormone-sensitive prostate cancer.1 The standard of care for systemic treatement in metastatic hormone-sensitive prostate cancer consists of androgen deprivation therapy (ADT) plus an androgen-receptor pathway inhibitor (ARPI) with or without docetaxel,1 but ADT monotherapy is commonly used in older patients and patients with frailty.2 ADT and ADT combination therapies are effective but induce adverse metabolic effects, most notably weight gain,3 loss of muscle or bone mass,4 and an increase in serious cardiovascular events.5 The population with incident prostate cancer also has a high proportion of older patients and patients with comorbidities, who are already affected by these conditions.6 Additionally, ARPIs are costly, resulting in low availability in low-income and middle-income countries. In these countries, a substantial increase in the number of patients diagnosed with advanced prostate cancer is expected in the future.7 Therefore, cheaper yet safe therapeutic strategies for use in common cancers, such as prostate cancer, are needed.
Metformin is an oral agent that is widely used to manage type 2 diabetes.8 Metformin does not induce hypoglycaemia, is well tolerated, and is inexpensive.8 Epidemiological evidence suggests that metformin use can reduce cancer risk and cancer deaths among people with diabetes.9 Metformin also has the potential to mitigate the metabolic changes known to be induced by ADT.
Various anticancer mechanisms for metformin have been suggested. Metformin is associated with activation of adenosine monophosphate-activated protein kinase (AMPK) and inhibition of mTOR, leading to reduced cellular metabolic activity, growth, and proliferation.10, 11, 12 High endogenous insulin concentrations, which are reduced by metformin, are also associated with mitogenic effects and tumour growth and proliferation.12
Clinical trials have addressed the utility of metformin in the treatment of prostate cancer, but only in small-scale trials and in various settings including both monotherapy and combination therapy. Outcome measures in these studies vary, with some focusing on metabolic effects alone and others focusing only on the effect on cancer progression.13, 14 None of these studies have been sufficiently powered to test the effect of metformin treatment on survival.
The STAMPEDE trial has tested new combination therapies in patients with locally-advanced or metastatic hormone-sensitive prostate cancer. The metformin arm of the STAMPEDE trial tested the standard of care plus metformin to ascertain the additive effect of metformin on survival and the potential mitigation of the adverse metabolic effects of ADT. Here, we report the results for patients with metastatic disease.
Research in context.
Evidence before this study
We searched PubMed for reports of clinical trials published between Jan 1, 2000, and March 1, 2025, in English, using the terms (“metformin”) and (“metastatic prostate cancer” or “metastatic prostatic neoplasm” or “mHSPC” or “mCRPC”). We also searched abstract books of major cancer conferences using the terms (“metformin”) and (“prostate cancer”) between Jan 1, 2020, and March 1, 2025. We identified six phase 2 trials (NCT01620593, MetAb-Pro, SAKK 08/09, TAXOMET, MANSMED, and SAKK 08/14), a small, randomised pilot study, and two post-hoc analyses from three phase 3 trials (CHAARTED, COU-AA-301, and COU-AA-302) investigating metformin with androgen deprivation therapy (ADT) either as monotherapy or in combination with other treatments in patients with metastatic prostate cancer. These trials showed conflicting results and were also not powered to give a conclusive result. To our knowledge, no phase 3 clinical trials have been done in patients with metastatic hormone-sensitive prostate cancer to assess whether addition of metformin to standard of care could improve outcomes in this patient population.
Added value of this study
This study, using the STAMPEDE trial platform, is, to our knowledge, the first large-scale randomised trial to test the addition of metformin to standard of care therapy in patients with metastatic hormone-sensitive prostate cancer. Randomised trials investigating this strategy have been small and underpowered. Metformin might also mitigate adverse metabolic changes, including metabolic syndrome, a substantial clinical problem induced by ADT, which is an essential component of standard of care in metastatic prostate cancer. Our results show that in the general population with metastatic hormone-sensitive prostate cancer, adding metformin to standard of care did not bring significant oncological or survival improvement overall. However, in patients with high-volume disease there was some evidence of a potential anticancer effect. Addition of metformin to standard of care was also beneficial in mitigating the adverse effects of ADT in patients with metastatic hormone-sensitive prostate cancer, irrespective of metastatic disease volume.
Implications of all the available evidence
Addition of metformin, a widely used, safe, and cheap metabolic regulatory drug to standard of care is not recommended for patients with metastatic hormone-sensitive prostate cancer in general. Further work is needed to better understand the potential anticancer effect observed in patients with high-volume disease and to identify patients who might benefit most from the addition of metformin to treatment.
Methods
Study design and participants
The STAMPEDE multi-arm, multi-stage, randomised phase 3 trial recruited patients with high-risk locally advanced or metastatic adenocarcinoma of the prostate staged by conventional imaging with isotope bone and CT scanning. Since trial initiation in 2005, ten research questions have been tested: this publication reports findings for the most recent research question, testing the addition of metformin to standard of care for non-diabetic (glycated haemoglobin [HbA1c] <48 mmol/mol [equivalent to <6·5%]) patients with metastatic disease with adequate renal function (glomerular filtration rate ≥45 ml/min/1·73 m2), and WHO performance status 0–2. There were no age restrictions. All patients were planned to receive long-term ADT, but could also receive additional standard of care treatments according to clinician choice. These treatments included radiotherapy to the prostate, docetaxel, or, from 2021, an ARPI. Full inclusion and exclusion criteria are provided in the protocol (appendix). This trial recruited from 112 hospitals in the UK and Switzerland to the STAMPEDE protocol as presented previously.15, 16 Patients were recruited to the study by the treating clinical team following clinical diagnosis and recorded centrally at the Medical Research Council (MRC) Clinical Trials Unit. Recruitment was higher than planned, partly because of the addition of a metabolic sub-study to explore in more detail the mechanisms underlying the metabolic effects of ADT and their potential mitigation using metformin; this sub-study opened in October, 2021. There have been six amendments to the protocol since the start of this comparison and all details are in section 22.1 of the protocol (appendix).
The trial was sponsored by University College London (UCL) and conducted by the MRC Clinical Trials Unit at UCL. All patients provided written informed consent, and the trial was done in accordance with Good Clinical Practice guidelines and the Declaration of Helsinki, with relevant regulatory and ethics approval. Ethics approval was granted by West Midlands Research Ethics Committee, now West Midlands, Edgbaston Reasearch Ethics Committee (04/MRE07/35). The STAMPEDE trial is registered with ClinicalTrials.gov, NCT00268476 and ISRCTN, ISRCTN78818544. Full details are available in the trial protocol (appendix).
Randomisation and masking
Patients were randomly assigned (1:1) to standard of care (control) or standard of care plus metformin. Random assignment was by telephone using minimisation with a random element of 20% (developed and maintained by the MRC Clinical Trials Unit at UCL), stratified for randomising hospital, age (<70 years vs ≥70 years), WHO performance status (0 vs 1 or 2), type of ADT, regular long-term use of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs; yes vs no), pelvic nodal status (positive vs negative), planned radiotherapy (yes vs no), and planned docetaxel or ARPI use (docetaxel vs abiraterone, enzalutamide, or apalutamide vs none). The trial was open label. Radiological images from patients were retrieved and analysed centrally to categorise disease volume independent of the treatment group patients were assigned to.
Procedures
Standard of care with long-term ADT started within 12 weeks before random assignment. Patients could receive additional docetaxel, abiraterone, enzalutamide, or apalutamide according to local protocols. Prostate radiotherapy was permitted.
Metformin was administered orally at a starting dose of 850 mg once daily, and increased to 850 mg twice daily after 4–6 weeks if tolerated. Metformin was recommended to be continued life-long for patients with metastatic disease if well tolerated. Dose reductions were allowed; detailed information is provided in the protocol (appendix). Patients could stop metformin at any time based on unacceptable toxic effects or patient choice. Reasons for cessation were documented by the trial team in the End of Research treatment case report form.
Patients were followed up every 6 weeks within the first 6 months, then every 12 weeks up to 2 years, then every 6 months up to 5 years, then annually. Assessments included prostate-specific antigen (PSA) testing, safety laboratory blood tests, and ascertainment of adverse events. Morphometric and metabolic parameters, measured at baseline and at regular intervals thereafter, included bodyweight, waist measurement, blood lipid concentrations, and glucose concentrations. Blood pressure was measured at baseline. The nadir PSA concentration was defined as the lowest PSA concentration within 24 weeks after random assignment; subsequent rises were defined as PSA progression (biochemical failure), as per the trial protocol (appendix). After random assignment, imaging frequency occurred according to local practice or clinician choice. Investigator-determined radiographic or local progression was reported according to the STAMPEDE protocol (appendix).
Metastatic disease volume was assessed by central review of baseline staging investigations. Retrospective collection of pre-randomisation bone and CT scans was done, with scans stored at the Christie Hospital (Manchester, UK) central imaging repository after completion of accrual but before analysis. Physicians (AS, OE-T, and YJ) classified patients by high-volume or low-volume disease using the CHAARTED criteria17 based on the number and site of bone metastases on isotope bone scan, and whether local sites identified visceral disease on CT scan.
Outcomes
The primary outcome measure was overall survival, defined as the time to death from any cause. All survival-based outcome measures were timed from random assignment.
Information on death for patients living in England and Wales was supplemented by linking patients to Civil Registrations of Death (CRD); these data were used in overall survival and prostate cancer-specific survival analysis but not for other cancer outcomes, where censoring for non-fatal events was uncertain. Causes of death were determined from death certificates in those linked with CRD and by site-assigned cause of death for those unlinked with CRD (predominantly patients in Scotland, Northern Ireland, and Switzerland).
Secondary outcome measures were prostate cancer-specific survival (time to prostate cancer death), metastatic progression-free survival (time to new metastases or progression of existing metastases or prostate cancer death), progression-free survival (as for metastatic progression-free survival, with the addition of local or lymph node progression), and failure-free survival (as for progression-free survival, with the addition of biochemical progression). Morphometric and metabolic outcome measures included change in weight, waist circumference, fasting glucose, triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol, and HbA1c. Symptomatic skeletal events, major adverse cardiac events, further metabolic outcomes, quality of life, and cost effectiveness will be analysed separately. Race and ethnicity data were not recorded.
Adverse events were assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE version 4.0) at all follow-up visits. Safety reporting of serious adverse events continued until disease progression or 30 days after cessation of metformin.
Statistical analysis
A prespecified statistical analysis plan was signed off before data extraction and is available in the appendix. A target sample size of 1800 men with metastatic disease was calculated using the nstage command in Stata version 13. The sample size assumed a median overall survival of 54 months in the control group, targeting a hazard ratio (HR) of 0·8, with 86% power and a 2·5% one-sided significance level after accounting for the shared use of the control group with one other experimental research group. One interim analysis went ahead, with data frozen on April 17, 2020, and presented at a meeting on May 15, 2020, with a one-sided α of 0·40, and the independent data monitoring committee recommended continuation based on the HR threshold for lack of sufficient activity not being met. The final analysis was triggered by the occurrence of at least 473 deaths in the control group—these were observed by July 3, 2024.
Primary analyses used the intention-to-treat population (all randomly assigned patients) except for recorded adverse events, which were analysed in the safety population (defined as patients starting treatment within randomly assigned groups), reported as the maximum grade per patient for each event. Serious adverse events were reported until disease progression in the control group and until both disease progression and 30 days after cessation of metformin in the research group. Median follow-up was calculated using a Kaplan-Meier method with reverse-censoring on death.
Time-to-event data were presented using Kaplan-Meier curves and analysed using Cox regression modelling to present HRs for treatment effect adjusted for stratification factors (excluding randomising hospital and type of long-term hormone therapy) and stratified for relevant time periods, defined by other recruiting comparisons and changes to standard of care. For overall survival and prostate cancer-specific survival outcomes, patients without an event were censored when last known to be alive; for patients linked to CRD data this date is defined as 30 days before the date of production of the CRD report by NHS England, and for patients not linked, this date is defined as the most recent date of any action received on follow-up forms. For other time-to-event outcome measures, patients were censored at the date of most recent follow-up or progression report (if not the progression event of interest). Medians are presented from flexible parametric models fitted to the data with five degrees of freedom. Prostate cancer-specific survival, failure-free survival, progression-free survival, and metastatic progression-free survival used a competing risks approach, with death from non-prostate cancer causes as the competing risk.
For Cox models, hazard ratios (HR) less than 1 favour adding metformin. Non-deviation from proportional hazards was checked using scaled Schoenfeld residuals regressed against the log of time.
Seven subgroup analyses of interest were prespecified in the statistical analysis plan: stratification factors (age, WHO status, aspirin or non-steroidal anti-inflammatory use, pelvic nodal status, planned radiotherapy, planned systemic therapy) and CHAARTED disease volume. Subgroup analyses were not formally designed (in terms of direction and size of effects or power) for identification of differing effects in these subgroups.
Changes in morphometric and metabolic factors were analysed at 24, 48, and 104 weeks using linear regression, adjusted for baseline value, height, and stratification factors as above.
All analyses were done in Stata version 18.
Role of the funding source
Cancer Research UK approved the study design and subsequent amendments. The funders of the study had no role in data collection, data analysis, data interpretation, or writing of the report.
Results
Between Sep 5, 2016, and Mar 31, 2023, 1874 patients with metastatic disease were randomly allocated to standard of care (n=938) or standard of care plus metformin (n=936; figure 1; appendix p 11). 1145 patients with non-metastatic disease were also recruited during this period; results for these patients will be reported separately. The STAMPEDE trial closed recruitment on March 31, 2023, and this report presents the final primary analysis for patients with metastatic disease in the metformin comparison followed up to July 3, 2024.
Figure 1.
Trial profile
CRD=civil registrations of death (provided by the Office for National Statistics). *Withdrawn does not include patients with data in the last 2 years. Patients who withdrew were censored at last known contact.
Baseline characteristics were similar across treatment groups (table 1). The median patient age was 69 years (IQR 63–73) and the median PSA was 84 ng/mL (24–352). 1758 (94%) of 1874 patients were newly diagnosed with metastatic disease and 116 (6%) were diagnosed with metachronous relapsing disease. 1543 (82%) of 1874 patients received ADT plus docetaxel and 52 (3%) received ADT plus abiraterone, enzalutamide, or apalutamide. For additional baseline characteristics and baseline morphometric and metabolic parameters by randomly assigned group see the appendix (pp 2–3). 809 (43%) of 1874 patients had low-volume disease according to the CHAARTED definition18 and 824 (44%) had high-volume disease. Scans were not available for 241 (13%) patients.
Table 1.
Baseline characteristics
| Standard of care (n=938) | Standard of care plus metformin (n=936) | |
|---|---|---|
| Disease category | ||
| De novo | 881 (94%) | 877 (94%) |
| Relapsing | 57 (6%) | 59 (6%) |
| Regional nodal status | ||
| N0 | 272 (29%) | 285 (30%) |
| N+ | 638 (68%) | 620 (66%) |
| NX | 28 (3%) | 31 (3%) |
| Bone metastases | ||
| No | 134 (14%) | 117 (13%) |
| Yes | 804 (86%) | 819 (88%) |
| Visceral metastases | ||
| No | 834 (89%) | 828 (88%) |
| Yes | 104 (11%) | 108 (12%) |
| Distant nodal metastases | ||
| No | 619 (66%) | 606 (65%) |
| Yes | 319 (34%) | 330 (35%) |
| CHAARTED volume | ||
| Low | 419 (45%) | 390 (42%) |
| High | 404 (43%) | 420 (45%) |
| Scans not available | 115 (12%) | 126 (13%) |
| WHO performance status | ||
| 0 | 701 (75%) | 701 (75%) |
| 1 | 227 (24%) | 216 (23%) |
| 2 | 10 (1%) | 19 (2%) |
| Systemic therapy (standard of care) | ||
| ADT alone | 135 (14%) | 144 (15%) |
| ADT plus docetaxel | 778 (83%) | 765 (82%) |
| ADT plus androgen receptor pathway inhibitor | 25 (3%) | 27 (3%) |
| Local radiotherapy planned | ||
| No | 822 (88%) | 830 (89%) |
| Yes | 116 (12%) | 106 (11%) |
| Age at random assignment, years | ||
| Median (IQR) | 69 (63–73) | 69 (63–74) |
| Range | 41–86 | 44–89 |
| Prostate-specific antigen at random assignment, ng/mL | ||
| Median (IQR) | 80 (24–296) | 87 (25–414) |
| Range | 0–10 178 | 0–9132 |
Data are n (%), unless otherwise indicated. ADT=androgen deprivation therapy.
897 (96%) of 936 patients in the standard of care plus metformin group were confirmed to have started metformin treatment, 24 (3%) patients had a missing metformin start date but were assumed to have started treatment, and 15 (2%) patients did not start metformin treatment. 28 (3%) of 897 patients stopped metformin within the first 30 days of treatment. The median time from random assignment to starting metformin was 7 days (IQR 3 to 14) and to stopping metformin was 39 months (IQR 13 to not reached). At database lock on July 3, 2024, 287 (58%) of 497 patients who remained in the trial were still receiving metformin. 134 (26%) of 510 patients who reported stopping metformin gave the reason excessive toxicity. 42 (2%) of 1874 patients stopped their participation in trial follow-up early and were censored at last contact. During follow-up, 26 (3%) of 938 patients in the control group reported starting metformin at some point. The median time to most recent case report form follow-up was 60 months (IQR 49 to 72). The median time to date last known to be alive was 69 months (60 to 79; using CRD data).
When incorporating data from CRD, 473 deaths were reported in the standard of care group; median survival was 61·8 months (IQR 29·7 to not reached). There were 453 deaths in the metformin group; median survival was 67·4 months (32·5 to not reached; HR 0·91, 95% CI 0·80–1·03; p=0·15; figure 2). We found no evidence of non-proportional hazards (p=0·14). Causes of death are presented in the appendix (p 3); the main cause of death was prostate cancer. A forest plot of the seven prespecified subgroup analyses is shown in the appendix (p 13). We found no strong suggestion of heterogeneity of effect for any of the prespecified subgroups. In patients with high-volume versus low-volume disease (as per CHAARTED),18 HRs for patients treated with metformin versus those who received standard of care were 0·79 (95% CI 0·67–0·94; p=0·0072) and 0·98 (0·78–1·23; p=0·87), respectively (figure 2). The p value for interaction was 0·12.
Figure 2.
Overall survival by treatment and metastatic disease volume
Shaded areas indicate 95% CIs. HR=hazard ratio. SOC=standard of care.
400 deaths in the standard of care group and 396 deaths in the metformin group were attributed to prostate cancer; we found no evidence of an effect of metformin on prostate cancer-specific survival in the overall population (HR 0·97, 95% CI 0·85–1·12; p=0·70; figure 3), nor any strong suggestion of heterogeneity of effect for any of the prespecified subgroups. In patients with high-volume versus low-volume disease, HRs for prostate cancer-specific survival were 0·85 (0·71–1·02; p=0·090) and 1·06 (0·82–1·38; p=0·64), respectively. The p value for interaction was 0·11.
Figure 3.
Prostate cancer-specific, progression-free, metastatic progression-free, and failure-free survival by treatment and metastatic disease volume
Shaded areas indicate 95% CIs. SHR=sub-hazard ratio (from competing risks analysis). SOC=standard of care.
There were 515 progression-free survival events in the standard of care group and 494 in the metformin group. We found no evidence that metformin affected progression-free survival in the overall population (HR 0·92, 95% CI 0·81–1·04; p=0·16; figure 3). However, we found some evidence of an interaction with metastatic volume in patients with high volume disease (HR 0·76, 95% CI 0·64–0·90; p=0·0011) compared with patients with low-volume disease (1·06, 0·86–1·32; p=0·57). The p value for interaction between treatment arm and volume of disease was 0·012. A similar pattern was seen for metastatic progression-free survival, with 486 events in the standard of care group and 461 events in the metformin group (overall HR 0·90, 95% CI 0·79–1·02; p=0·093), with a suggestion of metastatic volume interaction (HR 0·74, 95% CI 0·63–0·88; p=0·00054; and 1·04, 0·83–1·31; p=0·72 for high-volume and low-volume, respectively; p value for interaction was 0·013). We found no apparent benefit of metformin for failure-free survival (HR 0·94, 95% CI 0·84–1·05; p=0·30; (625 events in the standard of care group and 618 events in the metformin group; 877 [71%] of 1243 events were PSA failures) nor substantial indication of interaction with baseline disease volume. HRs were 0·84 (95% CI 0·72–0·98; p=0·030) and 1·00 (0·83–1·21; p=0·99) in high-volume disease and low-volume disease, respectively. The p value for interaction was 0·15.
At 24, 48, and 104 weeks, weight gain differed significantly between treatment groups (p<0·0001 at all timepoints). Based on the 583 participants with weight available at baseline and 104 weeks, patients who received standard of care gained a mean of 4·40 kg (95% CI 3·57 to 5·24) by 104 weeks whereas patients who received metformin gained a mean of 2·00 kg (1·31 to 2·69; mean difference –2·48, 95% CI –3·55 to –1·41). Statistically significant differences favouring metformin were also seen between groups at 104 weeks for changes in fasting glucose (n=685; mean difference –0·17 mmol/L, 95% CI –0·29 to –0·05; p=0·0044), total cholesterol (n=817; mean difference –0·16 mmol/L, –0·29 to –0·03; p=0·013), LDL cholesterol (n=747; mean difference –0·17 mmol/L, –0·29 to –0·05; p=0·0043), HbA1c (n=806; mean difference –1·01 mmol/mol, –1·56 to –0·46; p<0·0001), and waist measurements (n=324; –1·74 cm, –3·39 to –0·09; p=0·038). Differences at 24 weeks and 48 weeks were consistent with these groups differences, except for waist measurements, which were not significantly different at 24 weeks and 48 weeks. We found no evidence of difference in fasting triglycerides (n=751; –0·09 mmol/L, –0·21 to 0·02; p=0·10) or HDL cholesterol (n=816; –0·02 mmol/L, –0·08 to 0·05; p=0·62; figure 4; appendix p 4). There were no relevant differences in morphometric and metabolic factors, including BMI category, between patients with high-volume versus low-volume disease at baseline (appendix p 5).
Figure 4.
Morphological and metabolic outcomes by treatment (change from baseline)
Data shown are mean (95% CI). SOC=standard of care.
Similar proportions of patients reported CTCAE grade 1–5 adverse events in both study groups during the course of follow-up, with the exception of gastrointestinal and renal and urinary adverse events (table 2). Gastrointestinal adverse events were more common with metformin: 789 (86%) of 921 patients reported any gastrointestinal event versus 629 (67%) of 938 patients in the standard of care group. The difference was mostly driven by 600 (65%) of 921 patients in the metformin group and 350 (37%) of 938 patients in the standard of care group reporting diarrhoea and 292 (32%) patients in the metformin group and 215 (23%) patients in the standard of care group reporting nausea. Grade 3 diarrhoea was reported in 46 (5%) of 921 patients in the metformin group versus 29 (3%) of 938 patients in the standard of care group. Grade 1–2 renal and urinary adverse events were more common with metformin: 612 (66%) of 921 patients reported a grade 1–2 event versus 584 (62%) of 938 patients in the standard of care group. However, we found no significant difference in grade 3–5 renal and urinary events (39 [4%] of 921 patients in the metformin group and 34 [4%] of 938 patients in the standard of care arm reported a grade 3–5 event; table 2; appendix pp 6–9). The number of dose reductions for metformin is shown in the appendix (p 10). Grade 3 or worse adverse events were reported in 487 (52%) of 938 patients in the standard of care group and 523 (57%) of 921 patients in the standard of care plus metformin group. There were 286 serious adverse reactions, generally related to standard of care docetaxel (appendix p 10). Nine of 14 serious adverse reactions to metformin were in the gastrointestinal system. There was one hormone therapy-related death in each study group (cardiac disorders) and five docetaxel-related deaths in the standard of care group (one musculoskeletal and connective tissue, two infections, and two blood and lymphatic).
Table 2.
Adverse events in the safety population by body system and specific adverse events of interest in this population (not necessarily treatment-related)
|
Standard of care (n=938) |
Standard of care plus metformin (n=921) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Grade 1/2 | Grade 3 | Grade 4 | Grade 5 | Grade 1/2 | Grade 3 | Grade 4 | Grade 5 | ||
| Blood and lymphatic | 409 (44%) | 73 (8%) | 13 (1%) | 1 (<1%) | 458 (50%) | 68 (7%) | 17 (2%) | 1 (<1%) | |
| Cardiac | 48 (5%) | 21 (2%) | 4 (<1%) | 3 (<1%) | 49 (5%) | 35 (4%) | 4 (<1%) | 3 (<1%) | |
| Ear and labyrinth | 10 (1%) | 1 (<1%) | 0 | 1 (<1%) | 5 (1%) | 1 (<1%) | 0 | 0 | |
| Endocrine | 10 (1%) | 1 (<1%) | 0 | 0 | 11 (1%) | 0 | 0 | 0 | |
| Eye | 75 (8%) | 6 (1%) | 2 (<1%) | 0 | 77 (8%) | 10 (1%) | 1 (<1%) | 0 | |
| Gastrointestinal | 568 (61%) | 54 (6%) | 4 (<1%) | 3 (<1%) | 705 (77%) | 82 (9%) | 2 (<1%) | 0 | |
| Diarrhoea | 321 (34%) | 29 (3%) | 0 | 0 | 554 (60%) | 46 (5%) | 0 | 0 | |
| Nausea | 211 (22%) | 4 (<1%) | NA | NA | 285 (31%) | 7 (1%) | NA | NA | |
| Vomiting | 47 (5%) | 4 (<1%) | 0 | 0 | 68 (7%) | 5 (1%) | 0 | 0 | |
| Flatulence | 76 (8%) | 0 | 0 | 0 | 149 (16%) | 0 | 0 | 0 | |
| Dyspepsia | 96 (10%) | 1 (<1%) | 0 | 0 | 156 (17%) | 0 | 0 | 0 | |
| General disorders and administration site conditions | 748 (80%) | 53 (6%) | 2 (<1%) | 1 (<1%) | 745 (81%) | 57 (6%) | 3 (<1%) | 5 (1%) | |
| Fatigue | 749 (80%) | 34 (4%) | NA | NA | 746 (81%) | 33 (4%) | NA | NA | |
| Hepatobiliary | 4 (<1%) | 0 | 0 | 1 (<1%) | 3 (<1%) | 3 (<1%) | 1 (<1%) | 0 | |
| Immune system | 21 (2%) | 3 (<1%) | 0 | 0 | 26 (3%) | 3 (<1%) | 0 | 0 | |
| Infections | 189 (20%) | 80 (9%) | 9 (1%) | 3 (<1%) | 212 (23%) | 72 (8%) | 9 (1%) | 5 (1%) | |
| Injury | 16 (2%) | 19 (2%) | 0 | 1 (<1%) | 21 (2%) | 25 (3%) | 1 (<1%) | 0 | |
| Investigations | 426 (45%) | 65 (7%) | 16 (2%) | 0 | 434 (47%) | 64 (7%) | 32 (3%) | 0 | |
| Metabolism and nutrition | 280 (30%) | 16 (2%) | 3 (<1%) | 1 (<1%) | 325 (35%) | 19 (2%) | 4 (<1%) | 0 | |
| Musculoskeletal | 600 (64%) | 70 (7%) | 0 | 1 (<1%) | 608 (66%) | 68 (7%) | 1 (<1%) | 0 | |
| Neoplasms | 11 (1%) | 9 (1%) | 3 (<1%) | 3 (<1%) | 5 (1%) | 15 (2%) | 1 (<1%) | 9 (1%) | |
| Nervous system | 473 (50%) | 30 (3%) | 2 (<1%) | 2 (<1%) | 453 (49%) | 44 (5%) | 4 (<1%) | 1 (<1%) | |
| Psychiatric | 468 (50%) | 26 (3%) | 3 (<1%) | 0 | 488 (53%) | 22 (2%) | 0 | 0 | |
| Renal and urinary | 584 (62%) | 32 (3%) | 2 (<1%) | 0 | 612 (66%) | 37 (4%) | 2 (<1%) | 0 | |
| Acute kidney injury | 28 (3%) | 4 (<1%) | 0 | 0 | 24 (3%) | 8 (1%) | 0 | 0 | |
| Chronic kidney disease | 96 (10%) | 2 (<1%) | 0 | 0 | 92 (10%) | 3 (<1%) | 2 (<1%) | 0 | |
| Reproductive | 334 (36%) | 128 (14%) | 0 | 0 | 315 (34%) | 129 (14%) | 0 | 0 | |
| Respiratory | 323 (34%) | 25 (3%) | 1 (<1%) | 0 | 298 (32%) | 18 (2%) | 5 (1%) | 0 | |
| Skin | 468 (50%) | 4 (<1%) | 0 | 0 | 424 (46%) | 11 (1%) | 1 (<1%) | 0 | |
| Social circumstances | 0 | 1 (<1%) | 0 | 0 | 2 (<1%) | 1 (<1%) | 0 | 0 | |
| Surgical or medical procedures | 9 (1%) | 8 (1%) | 0 | 0 | 3 (<1%) | 5 (1%) | 0 | 0 | |
| Vascular | 664 (71%) | 91 (10%) | 1 (<1%) | 1 (<1%) | 661 (72%) | 96 (10%) | 3 (<1%) | 1 (<1%) | |
NA=not applicable (grade 4/5 does not exist in this side-effect term).
Discussion
Evidence of oncological benefit with metformin use in prostate cancer has been reported in epidemiological studies8, 9 but, to date, although some randomised clinical trials in advanced prostate cancer have suggested an oncological benefit13, 14 they have been too small for definitive comment. This open-label, randomised controlled trial within the STAMPEDE trial platform is the first to report the effects of metformin added to standard of care in patients with metastatic hormone-sensitive prostate cancer, tested at large scale. The data show that addition of metformin given orally at standard dose was generally well tolerated but did not result in the targeted benefit of a 20% reduction in risk of death in an unselected population. However, for men with high-volume disease, assessed centrally using CHAARTED criteria17 on conventional imaging with isotope bone scan and CT-MRI,18 there was some indication of potential oncological benefit in the prespecified subgroup analysis. However, although prespecified, these subgroup analyses were not formally powered to test such an interaction and therefore should be considered hypothesis-generating.
The biological rationale for such an anticancer effect might relate to the pleiotropic actions, including regulation of energetic function and dysfunction, and immunomodulatory properties of metformin.19 The regulation of cellular energy use is mainly driven by activation by metformin of the metabolic regulator, AMPK. AMPK is a key regulator of many intracellular metabolic processes, including intracellular energy control, glucose metabolism, macrophage-linked inflammation, and the immune response, all of which are important in cancer development and progression.19 Genetic aberrations associated with cancer are fundamentally linked to disordered metabolism and energy dysregulation through multiple cellular regulatory pathways.20, 21 In-vivo studies in animals have shown that genetic and pharmacological activation of AMPK provides a protective effect on prostate cancer progression by inducing catabolic metabolic reprogramming of prostate cancer cells. This catabolic state is characterised by increased mitochondrial gene expression, increased fatty acid oxidation, decreased lipogenic potential, decreased cell proliferation, and decreased cell motility, all of which are associated with prostate cancer metastasis and progression.22 Such mitochondrial aberrations are evident in human prostate cancer, where alterations in mitochondrial mass and mitochondrial complex 1 protein are observed.23 However, this finding does not explain the differential effect linked to disease volume that has been documented radiologically. High-volume disease is considered a more aggressive subtype of metastatic hormone-sensitive prostate cancer and is associated with heightened glycolytic activity (ie, Warburg effect) and reduced mitochondrial oxidative phosphorylation. Inhibition of mitochondrial complex I by metformin might selectively stress these metabolically inflexible cancer cells, which already operate near their energetic limits.24, 25, 26 This effect might account for the observed greater clinical benefit in this subgroup. Notably, there were no more patients with overweight or obesity with potentially higher insulin concentrations in the subgroup with high-volume disease compared with the subgroup with low-volume disease, a factor which might be a possible explanation for a difference in the effect of metformin in patients with high-volume or low-volume disease. Further elucidation and studies of the mechanisms underlying the observed oncological effect reported here are planned in translational studies linked to the STAMPEDE trial to understand which individuals might benefit most from addition of metformin to treatment. These studies include evaluation of metabolic and molecular alterations within the tumour and host at baseline and during treatment, which will allow investigation of the tumour–host interactions underpinning the observed response to metformin in patients with high-volume disease.
Addition of metformin to standard of care produced clear metabolic benefits irrespective of disease volume, inducing significant and sustained reductions in circulating glucose and HbA1c and total cholesterol and LDL cholesterol concentrations. Additionally, metformin significantly reduced clinically relevant weight gain induced by systemic treatment with ADT. These findings are novel and represent a substantial and potentially valuable treatment benefit for men with this lethal form of prostate cancer. Use of metformin as a supplement to ADT-based standard of care will have to be weighted against side-effects, namely diarrhoea.
Reduction in glucose and HbA1c is likely secondary to the known ability of metformin to reduce hepatic gluconeogenesis,27 and the control of key lipid levels by metformin is likely attributable to the AMPK-linked reduction in hepatic lipogenesis and cholesterol synthesis.19 These changes were accompanied by improved control of weight gain after starting ADT. ADT, which is essential for the treatment of metastatic prostate cancer, has recognised adverse side-effects, including reduced bone mineral density,28 metabolic changes—comprising weight gain, decreased muscle mass, increased insulin resistance, and increased visceral and subcutaneous abdominal fat29, 30, 31—and an increase in the cardiovascular event rate, particularly after combination treatment with ADT plus ARPI.5 Therefore, mitigation of these side-effects might be important when an ADT plus ARPI combination treatment is given. In this study, only a small number of patients had ADT plus ARPI combination therapy; most patients received ADT plus docetaxel. Addition of metformin to the regimen for men undergoing ADT, either as monotherapy or with intensification, provides an opportunity to reduce morbidities by using an inexpensive, widely available, low toxicity drug. These positive metabolic effects might, with longer observation, translate into reduced cardiovascular deaths; therefore, we will continue the follow-up of participants in our trial to test this hypothesis.
There are several limitations of this study. First, the open-label nature of the design is a potential limitation. However, identification of progression events is unlikely to be affected by clinicians' or patients' knowledge of use of metformin. Furthermore, outcomes of mortality and metabolic parameters are objective measures that would not be affected by the open-label design. Second, patient diaries for assessment of compliance were not included in this trial, therefore limiting our certainty about adherence to metformin. The population of patients included in the trial was also a limitation. Most patients had synchronous disease; therefore, extrapolation of the data to the population with metachronous disease is difficult. There was also a paucity of patients who received ADT plus an ARPI in the hormone-sensitive setting; it is unclear if the results of our study can be extrapolated to this current standard of care. However, despite ADT plus ARPI combination therapy being recommended in many guidelines, real-world evidence shows that the combination of ADT plus ARPI is not always used, and in some countries ARPIs are not reimbursed.
In conclusion, the addition of metformin to ADT with or without docetaxel therapy did not result in a significant improvement in survival compared with ADT with or without docetaxel in the overall population of patients with metastatic hormone-sensitive prostate cancer. However, there was some evidence of a potential anticancer effect in patients with high-volume disease. In our study, only 3% of participants received an ADT plus ARPI combination because most patients were accrued before ARPIs were approved for this indication in the UK. Further work is needed to assess the true utility of metformin when used in the population with high-volume disease alongside ADT plus ARPI (with or without docetaxel) combinations, which are the current standard of care. There was a substantial and significant improvement with the addition of metformin in key metabolic parameters known to be affected adversely by ADT, independent of disease volume. Such metabolic effects might translate into improved outcomes. As the addition of ARPI to ADT both increases survival1 and cardiovascular risk,5 the metabolic benefits of metformin might be even more relevant given the shift in standard of care to ADT plus ARPI since trial inception. Metformin is an inexpensive, well tolerated, and widely available medication. Although it would be inappropriate to recommend metformin to all patients for improving oncological outcomes, we found some evidence of benefit in a subgroup of patients with high-volume disease. We also found a beneficial effect on metabolic parameters in all comers. Some patients and doctors might consider these findings sufficient to consider adding metformin to ADT-based therapy in some patients who are at increased risk of cardiovascular disease and who are unable to change their lifestyle to mitigate the adverse consequences induced by impaired metabolic status after treatment with ADT.
Contributors
Data sharing
Individual participant data can be requested via the general enquiries email: mrcctu.ctuenquiries@ucl.ac.uk, as per the moderated access approach of the Medical Research Council Clinical Trials Unit at University College London. Upon approval, individual participant data that underlie the results reported in this Article, after de-identification (text, tables, figures, and appendices), will be provided with a data dictionary, protocol, and case record forms relevant to the data.
Declaration of interests
SGi reports consulting fees from Tolremo, Ipsen, and Avalere Health; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Silvio Grasso Consulting, WebMD-Medscape, Peer Voice, European Society for Medical Oncology, Meister ConCept, Swiss Group for Clinical Cancer Research (SAKK), DESO, AdMeTech Foundation, EPG Health, and Intellisphere; support for attending meetings or travel from AstraZeneca, Bayer, Intellisphere, and Gilead; patents planned, issued, or pending for prostate cancer biomarkers (WO2009138392); participation on a data safety monitoring board or advisory board for Orion, Bayer, Astrazeneca, Myriad Genetic, Amgen, MSD, Bristol-Myers Squibb, Daiichi Sankyo, Boehringer Ingelheim, Innomedica, Macrogenics, Astellas, and Novartis; and leadership or fiduciary roles in other board, society, committee, or advocacy group, paid or unpaid for Pfizer, Unicancer, LinkinVax, University of Applied Sciences and Arts of Southern Switzerland, Advanced Prostate Cancer Consensus Conference Society, Fond'action, European Organisation for Research and Treatment of Cancer, American Society of Oncology. NDJ reports funding from Cancer Research UK and Prostate Cancer UK for trial conduct and translational substudies. AS reports support for the present manuscript from the Prostate Cancer Foundation-John Black Charitable Foundation Young Investigator Award; grants or contracts from the Prostate Cancer UK Research & Innovation Award, The Urology Foundation, and Cancer Research UK; consulting fees from Veracyte; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Ipsen, Janssen, and Gedeon Richter; and support for attending meetings or travel from AIRA Matrix. OE-T reports grants or contracts from The Royal College of Surgeons England. GA reports support for the present manuscript from Janssen, Pfizer, AstraZeneca, Astellas, Novartis, Arvinas, Bayer, Sanofi, Propella, and Orion; royalties or licenses from The Institute of Cancer Research Rewards to Discoverers Scheme; employment by UCL, which has out-licensing agreements with Veracyte and Artera that they could gain commercially from; patents planned, issued, or pending for blood-based methylation markers (GB1915469.9, issued); and other financial or non-financial interests from Janssen, Pfizer, AstraZeneca, Astellas, Novartis, Arvinas, Bayer, Sanofi, Propella, and Orion, during the conduct of the study. SC reports consulting fees from Janssen, Astellas, and Amgen and participation on a data safety monitoring board or advisory board for Janssen, Astellas, and Pharmaand. WC reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Astellas, Bayer, Janssen, Novartis AAA, and Ipsen and support for attending meetings or travel from Astellas, Bayer, Janssen, Novartis AAA, and Ipsen. DPD reports royalties or licenses from the Institute of Cancer Research; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Janssen; patents planned, issued, or pending issued for a localisation and stabilisation device (EP1933709B1); and participation on a data safety monitoring board or advisory board for Janssen. OD reports support for attending meetings or travel from Novartis. EG reports patents planned, issued, or pending for Decipher use as a predictive biomarker for docetaxel patent (filed). AH reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from AstraZeneca, Janssen, Merck Serono, Novartis, and Pfizer; support for attending meetings or travel from Janssen and Merck Serono; and participation on a data safety monitoring board or advisory board for AstraZeneca, Janssen, and Pfizer. RJ reports grants or contracts from Astellas, Clovis, Exelixis, Bayer, and Roche; consulting fees from Janssen, Astellas, Bayer, Novartis, Pfizer, Merck Serono, MSD, Roche, Ipsen, and Bristol Myers Squibb; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Astellas, Janssen, Bayer, Pfizer, Merck Serono, MSD, Roche, Ipsen, Bristol Myers Squibb, and Merck Serono; support for attending meetings or travel from Bayer and Janssen; and participation on a data safety monitoring board or advisory board for Roche. REL reports support for the present manuscript from Medical Research Council Core Funding. OP reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from AstraZeneca and Merck; support for attending meetings or travel from Astellas, Janssen, MSD, and RECORDATI; and participation on a data safety monitoring board or advisory board for Janssen. CP reports consulting fees from Blue Earth Therapeutics, Novartis, and Janssen and participation on a data safety monitoring board or advisory board for Telix Pharmaceuticals. SS reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Jannsen, Bayer UK and Astra Zeneca and support for attending meetings or travel from Jannsen, Bayer UK, and Merck. JST reports support for attending meetings or travel from Jansen, Roche, and Bayer and participation on a data safety monitoring board or advisory board for AstraZeneca, Astellas, and Bayer. FT reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Silvio Grasso Consulting, SAKK, Merck, and Novartis; support for attending meetings or travel from Bayer; and participation on a data safety monitoring board or advisory board for Bayer. MRS reports grants or contracts from Astellas, Janssen, and Sanofi-Aventis; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Eisai, Eli-Lily, and Janssen; support for attending meetings or travel from Health Research Board, Ireland, Trials Research Methodology Network, Ireland, and National Cancer Grid, India; and participation on a data safety monitoring board or advisory board for various academic sponsors (none paid). All other authors declare no competing interests.
Acknowledgments
The STAMPEDE trial is funded by Cancer Research UK (CRUK_A12459). This work was supported by Prostate Cancer UK through a Research Innovation Award (RIA 18-ST2-021) and by the UK Medical Research Council (MRC_MC_UU_12023/25 and MC_UU_00004/01 and MC_UU_00004/02) as part of UK Research and Innovation. We thank all patients who participated and their families, the site staff and investigators, and the STAMPEDE oversight committees. All investigators are listed in the appendix (pp 198–336). Most patients in the STAMPEDE trial were recruited in the UK and recruiting sites receive funding for delivery of clinical research within the UK National Health Service (NHS) from the National Institute for Health and Care Research (NIHR) Clinical Research Network funded by the UK Department of Health. The views expressed in this Article are those of the authors and not necessarily those of the NHS, the NIHR, or the UK Department of Health. This research was enabled by secure provision of data from NHS England (Data Access Request Service application number DARS-NIC-59873-D8C6G) for use in these analyses. We give special thanks to Martino Pedrani for the clinical studies search on PubMed requested in the Research in context section.
Acknowledgments
Conceptualisation: SGi, NDJ, GA, DPD, RJ, ZM, MDM, WC, CP, MRS, MKBP, and NWC. Data curation: LM, MRS, MKBP, LCB, AS, OE-T, CMu, CA, and MB. Formal analysis: LM, MKBP, PD-M, and LCB. Funding acquisition: SGi, AS, MKBP, NDJ, and NWC. Investigation: SGi, NDJ, AS, OE-T, NWC, GA, HA-A, MV, JG, SB, NS, AJB, SC, DPD, OD, SGr, EG, UH, AMH, YJ, GJ, RJ, MK, ZM, MP-M, OP, CP, HR, MR, RS, SS, and JST. Methodology: MRS, LM, LCB, and MKBP. Project administration: CA, KC, PD-M, DCG, CG, REL, CMc, AM, CMu, MP-M, and LCB. Resources: SGi, NDJ, AS, OE-T, NWC, GA, HA-A, MV, JG, SB, NS, AJB, SC, DPD, OD, SGr, EG, UH, AMH, YJ, GJ, RJ, MK, ZM, MP-M, OP, CP, HR, MR, RS, SS, and JST. Supervision: SGi, AIA, NWC, NDJ, MRS, LCB, and MKBP. Validation: SGi, LM, NWC, NDJ, GA, LCB, and MKBP. Visualisation: LM, LCB, MRS, SGi, NDJ, GA, and NWC. Writing—original draft: SGi, LM, FT, NDJ, GA, and NWC. Writing—review and editing: all authors. RM, DM, and PW are the patient and public involvement representatives in the trial management group. All authors had full access to all the data in the study and had final responsibility for the decision to submit for publication. SGi, LM, FT, NDJ, LCB, and NWC have directly accessed and verified the underlying data reported in the manuscript.
Contributor Information
Silke Gillessen, Email: silke.gillessen@eoc.ch.
STAMPEDE investigators:
Gerhardt Attard, Simon Chowdhury, Noel Clarke, William Cross, David Dearnaley, Silke Gillessen, Nicholas James, Rob Jones, Zafar Malik, Chris Parker, J Martin Russell, Daniel Aebersold, John Anderson, Johann de Bono, Malcolm Mason, John Masters, Rick Popert, Alastair Ritchie, George Thalmann, David Matheson, Robin Millman, Patrick Williams, John Dwyer, David Hoe-Richardson, Jim Stansfeld, Claire Amos, Kitty Chan, Claire Murphy, Louise Brown, Duncan Gilbert, Ruth Langley, Mahesh Parmar, Matthew Sydes, Nafisah Atako, Cheryl Pugh, Hoda Abdel-Aty, Minal Padden-Modi, Mahaz Kayani, Sarah Howlett, Hannah Rush, Clare Gilson, Archie MacNair, Richard Emsley, Bertrand Tombal, Ronald de Wit, Chris Williams, John Yarnold, Doug Altman, Reg Hall, Paula Ghaneh, Tim Clayton, Jan-Erik Dember, Paul Nash, James Larkin, Jonathan Ledermann, Richard Emsley, John Fitzpatrick, Alan Horwich, David Kirk, Jim Paul, Louise Brown, Peter Dutey-Magni, Laura Murphy, Matthew Nankivell, Mahesh Parmar, Matthew Sydes, Sophie Barthel, Adrian Cook, Daniel Bratton, Christopher Brawley, Babak Choodari-Oskooei, Trinh Duong, Andrew Embleton, Melissa Gannon, Fiona Ingleby, Elizabeth James, Rachel Jinks, Gordana Jovic, Patrick Royston, Melissa Spears, Kitty Chan, Claire Amos, Charlene Carvalho, Mazna Anjun, Anna Griffiths, Fleur Hudson, Panos Maniatis, Connor McAlpine, Claire Murphy, Claire Shakeshaft, Horeja Njai, Shabinah Ali, Sofeya Ishqa, Dipa Noor, Malissa Richmond, Karen Sanders, Lily Clarke, Michelle Buckner, Nafisah Atako, Alanna Brown, Joanna Calvert, Rahela Choudhury, Zoe Cotton, Adam Cursley, Tom Fairfield, Silvia Forcat, Michelle Gabriel, Charlene Green, Adam Gregory, Anna Herasimtschuk, Caroline Hogan, Brooke Jackson, Sarah Jackson, Neil Kelk, James Latham, Dymphna Lee, Sarah Miller, Sharon Naylor, Dipa Noor, Jacqui Nuttall, Jenny Petrie, Cheryl Pugh, Orla Prendiville, Karen Sanders, Francesca Schiavone, Clare Shakeshaft, Aminata Sy, Charlotte Tyson, Hannah Vaughan, Christopher Wanstall, Katie Ward, Melanie Weiss, Arlen Wilcox, Hoda Abdel-Aty, Duncan Gilbert, Ruth Langley, Mahaz Kayani, Minal Padden-Modi, Sarah Howlett, Clare Gilson, Hannah Rush, Archie Macnair, Sarah Meredith, Alastair Ritchie, Christina Chung, Carlos Diaz-Montana, Georgia Marley, Lindsey Masters, Mary Rauchenberger, Stephen Townsend, Nadine Van-Looy, Carly Au, Will Cragg, Dominic Hague, Zaheer Islam, Sajad Khan, Dominic Mounsey, Nancy Tappenden, Nadine Van-Looy, Shaan Akbar, Yumna Ali, Ify Ejizu-Allen, Daneil Clarke, Donna Dobson, Abinayah Baskaran, Isabella Jaques, Alexander Lawton, Margaret Hook, Nazia Parkar, Eva Ades, Carly Au, Katherine Beaney, Nargis Begum, Katharine Bellenger, Lina Bergstrom, Veronica Birzu, Robin Carpenter, Elizabeth Clark, Emma Donoghue, Amy Fiddament, Shree Gajjar, Hannah Gardner, Jenna Grabey, Richard Gracie, Charlene Green, Adam Gregory, Dominic Hague, Shama Hassan, Jordan Hedges, Robyn Henry-Cockles, William Hudson, Sofeya Ishaq, Danielle Johnson, Saba Khan, Zohrah Khan, Linda Ly, Adele Mabley, Georgia Mannion-Krase, Jacque Millett, Myfanwy Nicholas, Rachel Ogunleye, Meghna Pandya, Reena Patel, Sara Peres, Tasmin Philips, Philip Pollock, Chathurika Rajapakse, Tim Smith, Hannah Sweeney, Arpita Upadhyaya, Laura Van Dyck, Hannah Vaughan, Peter Vaughan, Katie Ward, Steph Wetton, Andrew Whitney, Selin Yurdakul, Fleur Hudson, Nicola Joffe, Macey Murray, Tracey Fisher, Lynda Micklewright, Elizabeth Adesanya, Yumna Ali, Atma Amin, Hannah Babiker, Bryony Bathie, Helen Chapman, Georgia Cowley, Leigh Dobson, James Dunn, Robbie Dunn, Amy Fiddament, Ben Forson, Adam Gregory, Nasir Jamil, Tasheeka Jeyapalan, Sherwen Kang, Harry Kitson, Rebecca Lo, Joseph Martin, Nour Merzouki, Lynda Micklewright, Meghna Pandya, Ray Phillips, Jamie Simmons, Shanaz Sohail, Jeevan Sohal, Crystallynn The, Nat Thorogood, Stephanie Tsenti, Alexandra Wadia, Stephanie Wetton, Sarah Burdett, David Fisher, Peter Godolphin, Larysa Rydzewska, Jayne Tierney, Claire Vale, Sarah Banbury, Lesley Brempong, Emmanuel Harding, Gillian Hurst, Nishat Tasnim, Jemima Thompson, Estelle Cassolly, Pierre Fustier, Eloïse Kremer, Corinne Schar, Adnan Ali, Radhi Anand, Hassan Douis, Dan Berney, Mick Brown, Ros Eeles, Omar El-Taji, Stephenie Friedrich, Emily Grist, Anis A Hamid, Aine Haran, Craig Jones, A M Mahedi Hassan, Alex Hoyle, Sakunthala Kudahetti, Sharanpreet Lall, Gianmarco Leone, Hing Leung, Stefano Lise, Larissa Mendes, Karolina Nowakowska-Pawelkowicz, Charles Parker, Marina Parry, Alison Parry-Jones, Ashwin Sachdeva, Chris Sweeney, Suparna Thakali, Nina Tinariu, Maria Vico, Sara Santos Vidal, Daniel Wetterskog, Anna Wingate, Carla Bautista, Paolo Cremaschi, Thomas Hambrock, Alex Landless, Nik Matthews, Mariana Buongermino Pereira, Kamila Sychowska, David Waugh, Leila Zakka, Christian Smith, Christine Kotonya, Elin Jones, Helen Tench, Mark Narain, Philip Jones, Russel Canavan, Sajid Durrani, Emma Nurse, Gwenan Parry Jones, Kirsty Marie Dennett, Rhian Elin Jones, Sandra Griffiths nee Evens, Cerith Morgan, Kenneth Richard Williams, Llinos Strange, Sean Thomas, Toby Frederick Trugeion-Smith, Basharat Jameel, Bleddyn Edwards, Geraint Morgan, John Edwards, Donna Robson, Heather McGuinness, Ronda Loosley, Claire Duggan, Sarah Jones, Abigail Hynes, Rebecca Wolf-Roberts, Albert Edwards, Charlotte Mott, Ifigenia Vasiliadou, Lavarniya Rajakumar, Mathini Sridharan, Patryk Brulinski, Rakesh Raman, Rohit Malde, Stephane Tankoua, Arafat Mizra, Carys Thomas, Clary Evans, Kannon Nathan, Kathryn Lees, Mathilda Cominos, Matthew Fenton, Mohammed Osman, Natasha Mithal, Sharon Beesley, Sugeeta Sukumar, Udaiveer Panwar, Coral Greenstreet, Hayley Blackgrove, Katy Taylor, Victoria Williamson, Natalie Catt, Arafat Mirza, Sam Gibson, Steve Dann, Andrew Gillian, Miguel Capo-Mir, Cindy Slater, Hasmath Marjolin, Nikki Crisp, Rachel Larkins, Sandra Holness, Sarah Lines, Susan Rogers, Tessa Hammond, Claire White, Julie Buckley, Laura Kehoe, Lesley Rose, Louise Gladwell, Sarah Lightfoot, Tracy Boakes, Alba Tubau, Bonny Appleby, Linda Wray, Louise Allen, Marian Wood, Adedolapo Sanni, Claire Pelham, Elizabeth Williamson, Hilary Zurakovsky, Jill Baker, Joanne Williams, Julie-Ann Davies, Karen Robinson, Kathleen (Kathy) Walsh, Kim Mears, Kim Travis, Margaret Lipsham, Paula Whichelo, Sharon Middleton, Sue Kelly, Susan Drakeley, Sydnie Loveland, Molua Young, Denise Crawford, Ami Sabharwal, Andy Theobold, Janice Carpenter, Katherine Hyde, Thinn Pwint, Christopher Alcock, Gerard Andrade, Joanne Brady, Niki Panakis, Philip Camilleri, Prabir Chakraborti, Sean O'Cathail, Jonathan Greenland, Moncy Mathew, Rahul Kurup, Neil Trew-Smith, Alice Ngumo, Gail Varley, Janet Weir, Manisha Joshi, Siobhan Gettings, Cheryl Padilla-Harris, Maggie Aldersley, Margaret Bowerbank, Michelle Taylor-Siddons, Tracey Stammers, Anna Osadcow, Kathryn Herbert, Rossana Mancinelli, Sarah Manyangadze, Christine Collins, Hazel Wynn, Iram Husain, Jasvinder Bains, Roisin Kavanagh, Andrew Protheroe, Aisha Tufail, David McIntosh, Helena Belikova, Jawaher Ansari, Rebecca Muirhead, Xia Ren, Christina Lai, Esfandiyar Khan, Hilary Glen, Lye Mun Tho, Nicholas Macleod, Rana Mahmood, Stefan Nowich, Kirsty O'Hara, Kristy Ross, Brian McGlynn, Mark Wilson, Philip Cannon, Kathleen Smith, Deborah Dunn, Jane McClements, Susan Walton, Alison Murphy, Danielle Gilmour, Elaine Watson, Lillian White, Lynne McNeil, Margaret McKernan, Sharon Meehan, Clare Love, Claudia Coubrough (Turley), Danna Yorston, Diane Woodburn, Dianne Hunter, Jenna Mitchell, Kirsten Laws (nee Borthwick), Ami Mehta, Andrew Eichholz, Anita Mitra, Annette Hawkins, Emily Scott, Gehan Soosaipillai, Gillian Marks, Kate Smith, Kimberley Durno, Magdalena Kubiak, Sarah Needleman, Ursula McGovern, Danielle Collier, Andie David, Panayiotis Panayiotou, Heather Hughes, Prital Patel, Sandra Faustino, Anita Amadi, Alice Coady, Christine Ellis, Veronica Conteh, Becky Holbrook, Ajaz Lone, Chantal Oelofse, Elizabeth Kershaw, Faisal Hussain, Mohini Varughese, Peter Stephens, Philippa Smith, Sarah Park, Victoria Ford, Andy Bull, Denise Sheehan, Elizabeth Toy, Maria Martinez, Amy Thomas, Chloe Peters, Hannah Ong, Jenna Furse, Nyasha Manomano, Jeffrey man sum Chan, Joshua Gregory, Michal Ian Lamparski, Thomas Baddick, Eng Ong, Henry Goss, Martin Moody, Rufus Smith, Ashley Hanson, Katherine Horder, Maria Beaumont, Rebecca Davey, Fiona Thomas, Helen Black, Laura Hanson, Lynne Van-Koutrik, Lynsey Balmbra-Jenks, Natalie Kemp, Samantha Ley, Susan Collard, Alicia Leal-Santos, Faye Windsor, Judyta Lomza, M Timmermann, Cyrill Rentsch, Frank Stenner-Liewen, Nicole Ebinger, Stephen Wyler, N Ott, Cyrill Rentsch, Eloise Kremer, Heike Puschel, Heike Puschel, Mana Farsad, Nicole Neumann, Simone Marini, Bettina Seifest, Kristina Muller, Alexander Bachmann, Christoph Rochlitz, Dileep Soory, Hilawati Yusof, Ingrid White, Rosalyne Westley, Sangeeta Paisey, David Barlow, Eva Letalova, Jenny Nobes, Joanna Stokoe, Katharine Webb, Katherine Aitken, Katie Wood, Katie Wood, Rao Vuyyuru, Richard Shaffer, Sree Susaria, Teresa Guerrero-Urbano, Jo-Anna Conyngham, Jo-Anna Conyngham, Lauriane Kerwood, Lorraine Poole, Louise Beattie, Rebecca Wills, Zoe Finlay, Rachel Bryan, Duncan Cooke, Godfrey Bownie-Mukumbu, Roger Hudson, Bintha Paruthickal, Catherine McLean, Jackie Smith, Nanda Basker, Pennie Porter, Abigail Edwards, Adrienn Fazekasne Fulep, Angela Frith, Christine Podesta, Fasar Sarwar, Helen Richards, Victoria Corner, Carmen Wu, Catherine Rimington, Christina Narh, Claire Williams, Julie Gwilt, Kathryn Leach (nee Noake), Liz Happle, Sara Fawcitt, Abigail Gee, Catherine McDonald, Claire Dyke, Frances Du Feu, Georgina Gullick, Ioana Fodor, Kathryn Falconer, Nathalie Webber, Tom Wilson, Abigail Jenner, Chris Williams, Christine Elwell, Gareth Ayre, Hugh Newman, Lorna Hawley, Mark Beresford, Matthew Sephton, Olivera Frim, Penny Kehagioglou, Susan Masson, Abigail Pocock, Claire Barron, Jill MacDonald-Burn, Joanne Avis, Leonie Harrison, Rachael Bolitho, Rachael Exley, Samantha Williams, Shaolin Chidavaenzi, Guillaume Livera, Joseph Needham, Roland Wynn-Williams, Michael Daly, Tom Tylee, Amy Singh, Joanna Wilson, Kristelle Vassallo, Rowan Appleby, Vicki Portingale, Beatrice Hamilton, Carey Milsom (nee Logan), Christine Cox, Kate Moloney, Ruth Brydon-Hill, Samantha Curtis, Sarah Murdoch, Yuko Francis, Agata Leonarska, Bryony Robertson, Carolina Juan Chofre, Claire Davis, Eve Tomlinson, Jane Crozier, Jess White, Katarzyna Machura, Laura Cini, Rebecca Wassall, Carly Laxon-Takooree, Claire Craige, Hannah Blades, Jackie Davies, Margaret Macmillan, Vicki Clarke, Tania Williams (Née Allen), Amir Montazeri, Azman Ibrahim, Helen Innes, Isabel Syndikus, Peter Robson, Shaun Tolan, Zafar Malik, Elizabeth Gallimore, Jodie Henderson, Rachel Pritchard, Sarah Dalby, Emma Whitby, Emma Whitby, Laura McAllister, Ian Allen, Ian Allen, Matthew Stott, Paul Griffiths, Priyank Patel, Burhan Zavery, Wesley Artist, Annemieke Earnshaw, Elizabeth Harrison, Sharon Dunn (nee Johnson), Sue Green, Diane Fildes, Helen Flint, Sandra Robinson, Caroline Dunn, Claire Harwood, Jess Hulse, Katie Sloan, Suzanne Maloney, Dawn Porter, Lisa Dobson (nee Child), Catherine Gray, Claire Daisey, Claire Rooney, Laura Feeney, Laura Mooney, Michael McMahon, Nicola Hill, Orla Houlihan, Patricia Calisaya, Peter Bryson, Phil Turner, Rachel Ellis, Sai Jonnada, Seosamh McCauley, Swati Ray, Aiden Cole, Ciaran Fairmichael, Darren Mitchell, David Stewart, Jackie Harney, Jonathan McAleese, Lois Mulholland, Lucy Jellett, Melvyn Ang, Paula McCloskey, Poh Lin Shum, Prantik Das, Rebecca Goody, Rhun Evans, Ruth Eakin, Ruth Johnston, Salil Vengalil, Sarah McGahey, Stephen Stranex, Suneil Jain, Aine McKeown, Alison Logie, Jemma Robinson, Karen McKenna, Benedict Dadebo, Keith Rooney, Michael Hanna, William Snelling, Chris Hagan, Jonathan Thompson, Patrick Keane, Peter Clarke, Ciara McIlmunn, Diane Law, Ellen Brown, Fiona Tarpey, Karen Campfield, Kerry Nicholls, Margot Creighton, Eileen Dillon, Joanne McAllister, Kairen McCloy, Linda McNeice, Lynsey Morrow, Stacey Hetherington, Wendy Cunningham, Adrina O'Donnell, Catherine Davidson, Chryelle McAlister, Grace Lavery, Karen Allen (nee Parsons), Sara McCusker(nee Stokes), Sharon McClean, Sophie Lynch, Aishleen Brunton, Angela Morrison, Angela Rosbotham, Barbara Harvey, Eimear Henry, Emma Hanna, Geraldine Douris, Joanne Todd, Mairead Devine, Naomi Hill, Ruth Boyd, Sharon Hynds, Shirley McKenna, Joe O'Sullivan, Gianfranco Pesce, Maria Delgrande, Ngwa Che Azinwi, Ricardo Pereira Mestre, Vittoria Espeli, Carolina De Almeida, Eloise Kremer, Timo Nannen, Beat Roth, Simone Rimoldi, Susan Meierhans, Anselm Lafita, Anna-Katharina Herrmann, Antje Ulrich, Barbara Uhlmann, Eloise Kremer, Kathi Ochsner, Daniel Aebersold, Jörg Beyer, George Thalmann, Annette Winkler Vatter, Béatrice Zimmerli Schwab, Eloise Kremer, Silvia Hanselmann, Markus Borner, Amarpal Bains, Arvind Tripathy, Daniel Henderson, Frances Shaw, Jay Ansari, Lalit Pallan, Robert Stevenson, Sachin Trivedi, Sameed Hussain, Sudha Karanam, Syed Tirmazy, Abel Zachariah, Anjali Zarkar, Daniel Ford, David Fackrell, Emilio Porfiri, Erica Beaumont, Hannah Tween, Jenny Pascoe, Atiqa Ahmed, Charlotte Sabine, Charlotte Trinham, Daniella Lynch, Keia Spooner, Laura Butler, Laura Butler, Laura Caley, Rosie Henvey, Samarah Haq, Sanya Shafiq, Sibil Fernandez, Stephanie Palmer, Zhane Peterkin, Andrew Palmer, Biruk Asfaw, Christopher McGhee, Fahd Niaz, Michael Tarn, Richard Winter, Simon Horley, Steven Shanu, Adrian Kelly, Brian Gammon, Chen Bartlett, James Whitehouse, Vijay Patel, Vishy Veeranna, Aliyah Mannan, Amy Orme, Debbie Devonport, Fiona Evans, Golaleh McGinnell, Gullinder Jokhi, Karen Tester, Kathryn Adams, Lea Booth, Madhura Chandrashekara, Michelle Bates, Nasreen Akhtar, Nicola Betteridge, Parminder Sohal, Ellen Drew, Joanne Dasgin, Pamela Jones, Alice Longe, Alice Longe, Alison Grant, Amanda Davies, Amisha Desai, Amna Shah, Ann Schumacher, Arlene Oldan, Emma Bruce, Hannah Tolson, Heather Jones, Helen Jones, Helen Preston, Janet Prentice, Jasbinder Kaur, Jenny Hiley, Jill Lyons, Julia Sampson, Kamaldeep Ajimal, Lisa Thomas, Lisa - Marie Brueton, Mahmoda Begum, Maria Bandeira, Nicola Anderson, Salma Afzal, Sam Hopkins (nee Poole), Sara Diffley, Shaleen Bishop, Sharon Holmes, Tracy Soulsby, Trish Brady, Alison Maidment, Angela Williams, Claire Brown, Claire Draycott, Fiona Catherine Stead, Gemma Cole, Harriet Goddard, Helen Clarke, Jane Cook, Joanna Gray (nee Finney), Julie Simpson, Marion Tatman, Mary (Ellen) Drew, Penny Goodby (nee Harbach, Rosemarie Seadon, Yin May Chin, Nicholas James, Ahmed Salah, Alexandra Ferrera, Andrew Brocklehurst, Anthea Cree, Danya Abdulwahid, Ilyas Ahmed, Jasima Latif, Jennifer King, Karan Patel, Omi Parikh, Parth Desai, Prasad Kellati, Richard Walshaw, Sophia Callaghan, Sophie Raby, Twesige Mugisa, William Croxford, Zhu Oong, Ajay Mehta, Deborah Williamson, Falalu Danwata, Graham Read, Imran Haidar, Marcus Wise, Ruth Conroy, Tanmay Mukhopadhyay, Win Soe, Zia Rehman, Rizwana Hussain, Ana Batista, Farrah Burrows, Fatima Butt, Humairaa Timol, Naomi Charlton, Bethany Fielding, Andrew Hunnisett, Andrew Lancaster, Darren Rusk, James Grunshaw, Joseph Dykes, Matthew Lovell, Nicholas Pounder, Stephen Kilroy, Dayle Squires, Hani Hanna, Alison Blackburn, Deborah Smith, Farzana Patel, Jacqueline Thomas, Jacqueline Thomas, Kathryn Hayes, Lynsey Waring, Lynsey Waring, Angela Hugill, Helen Frankland, Janet Ryan-Smith, Sue Ashworth, Alexandra McCarrick, Christina Robinson, Debbie Sutton, Gaynor Bowen, Jackie Carey, Jackie Nuttall, Jan Flaherty, Jennifer McCallum, Jenny Cockerill-Taylor, Jessica Whiston, Marianna Theodoulou, Maricica Zabrautanu, Philippa Springle, Rachel Bolton, Samatha Guy, Sarah Ainsworth, Sarah Keith, Sarah Keith, Tracey Kilduff, Victoria Taylor, Diane Forrest, Hazel Aston, Helene Chorley, Jeanette Hargreaves, Karen Beard, Karen Jewers, Vivienne Tickle, Ajay Mehta, Tony Elliott, Karen Lee, Gillian Mobb, Ling Lee, Hemant Patel, Michael Pantelides, Richard Jones, Robert Hull, Janet Keegan, Shirley Cocks, Charlotte Lever, Debbie Forkin, Janine Hurst, Julie Chadwick, Louise Dawson, Raksha Mistry, Sally Shaw, Zoe Gall, Collette Hunt, Karen Jewers, Lindsay Rawlinson, Ana Fernandez-Ots, Andrew Sloan, Christian Arias, David Ballesteros-Quintail, Sekar Kittappa, Sindhu Ramamurthy, Miguel Panades, Prantik Das, Eileen Busby, Gunjan Phalod, Karen Metcalf, Sally Ann Molsher, Andrew Judd, Simon Archer, Beverley Mashegede, Isobel Thomas, Kimberley Netherton, Kinga Szymiczek, Laura Walsh, Kerry Pettitt, Victoria Knight (n. Sherburn), Amanda Roper, Amy Kirkby, Giuseppe Banna, Helen Carolan, Helen Palmer, Jayne Borley, Jenny Salmon, Jo Fletcher, Rebecca Spencer, Tara Lawrence nee Palmer, Alice Latty, Anita Young, Bryony Saint, Carol Lockwood, Trish Tsuro, Kenneth Oguejiofor, Matthew Roberts, Deborah Hands, George Astras, Joe Davies, Rao Vuyyuru, Sue Brock, Tom Geldart, Julie Thomson, Laura Purandare, Mirela Mukaj, Natasha Ottley, Taslima Rabbi, Alison Hogan, Rachel Bower, Ben Loat, Cameron Huck, David Chrastek, Joseph Cavill, Luke Vamplew, Carlton Rowlands, Roger Hudson, Emma Sharland, Joanne Sheppard, Cathie Purnell, Linda Purandare, Min Wu, Katherine Major, Lynsey Houlton, Rebecca Miln, Sarah Savage, Sophie Jackson, Stephanie Jones, Tiffany Joyce, Eve Broadley, Kate Preece, Natalya Boyd, Adel Jebar, Andrew Viggars, Ann Henry, Anthi Zeniou, Catherine Handforth, Charlotte Richardson, Christopher Williams, Eldho Joseph, Emily Montague, Finbar Slevin, Ian Boon, Jessica Pearce, Leila Koudsi, Louise Karsera, Love Goyal, Lucy Jones, Lucy Ward, Manjusha Soni, Reem Mahmood, Sally Martin, Samuel Briggs, Simon Brown, Sohail Mughal, Sree Rodda, Carmel Loughrey, Dan Lee, Ganesan Jeyasangar, Jamal Zekri, Sue Cheeseman, Susan Cheeseman, You Yone, Eleanor Waldron, Jannika Lazarte, Lucille Kenyon, Qamar Akbar, Declan Ryan-Wakeling, Kelvin Stewart, Leslie Masters, Umair Hamid, Mohammed Patel, Osman Chohan, Richard Benton, Carol Firth, Dawn McNulty, Helen Wilson, Kay Cockroft, Manitha Vinod, Wendy Cardozo, Hayley Inman, Jane Sewell, Sarah Tinker, Chandran Nallathambi, Charlotte Johnson-Smith, Elizabeth McIntosh, Gail Opio-Te, Jacqueline Quantrill, Kim Storton, Robina Ghulam, Shefali Parikh, Susan Shorter, Victoria Drew, Anne Marie Kay, Laura Jaques, Linda Bamford, Sophia Khan, Sophie Stephenson, Ashok Nikapota, Aun Mohammad, George Plantaniotis, Angus Robinson, Daniel Henderson, David Bloomfield, George Devtsch, George Plataniotis, Jackie Sham, Marie Wilkins, Tarun Durga, Vivien Tse, Angela Man, Catherine Hunter, Chritianne Whitfield, Lisa Furnival, Rachel Rose Edmunds, Samantha Hodges, Summer Ibrahim, Jean Tremlett, Andrew Hart, Matthew Seal, Paul Frattaroli, Sebastien Martin, Tiago Rodrigues, Simon Matthews, Stephen Brown, Caroline Walker, Dorota Bak-Blaz, Karen Walker, Emma Foreman, Alison Porges, Amy Murray, Annie Oliver, Elizabeth Corbett, Jane Peterson, Joanne Magennis, Jodie Smith, Katie Langford, Lucy Curtis, Poppy Lavender, Ranee Lactao, Bobbie Yoong, Elaine Noon, Helen Mitchell, Jane Dexter, Jane Hanson, Julie Smith, Kirsty Bracewell, Lisa Barrott, Maggie Cole, Monika Musiol, Pauline Martin, Sue Trotter, Tamsin Kent, Tenesa Sargent, Victoria Sellick, Amit Bahl, Chris Herbert, Emily Foulstone, Hugh Newman, Jyothsna Chennupati, Mark Beresford, Paula Wilson, Serena Hilman, Susan Masson, Eve Watson, Kay Drury, Azeem Arshad, Nick Robins, Sibusiso Dhladhla, Harvey Dymond, Ian Penwarden, Lloyd Abood, Marc Coe, Robert Hollister, Stephen Lang, Tristan Grey, Shalini Mohan, Beth Thorne, Amy Holloway, Bryony Parrish, Helen Saldanha, Hayley Jones, Jayne Leonard, Kimberly Rockley, Lindsay Ball, Lindsay Ball, Polly Gingell, Sally-Ann Hall, Sandra Williams (nee Price), Sarah Bishop, Seonaid Wright, Sharon Short, Ahmed Salah, Andrew Brocklehurst, Anthea Cree, Danya Abdulwahid, Ilyas Ahmed, Karan Patel, Omi Parikh, Prasad Kellati, Richard Walshaw, Twesige Mugisa, Deborah Williamson, Imran Haidar, Marcus Wise, Ruth Conroy, Tanmay Mukhopadhyay, Win Soe, Zia Rehman, Rizwana Hussain, Ana Batista, Fatima Butt, Humairaa Timol, Bethany Fielding, Darren Rusk, Matthew Lovell, Stephen Kilroy, Dayle Squires, Hani Hanna, Farzana Patel, Angela Hugill, Helen Frankland, Janet Ryan-Smith, Sue Ashworth, Alexandra McCarrick, Christina Robinson, Debbie Sutton, Gaynor Bowen, Jackie Carey, Jan Flaherty, Karen Riley, Karen Riley, Philippa Springle, Samatha Guy, Sarah Ainsworth, Tracey Kilduff, Victoria Taylor, Diane Forrest, Helene Chorley, Jeanette Hargreaves, Karen Beard, Karen Jewers, Louise Dawson, Vivienne Tickle, Prabir Chakraborti, Rosemary Corfield, Anita Szita, Chandrani Mallik, Rohit Malde, Seheli Bandyopahdyay, Sudipta Datta, Chris Curtis, Dakshinamoorthy Muthukumar, Divya Ramadasan, Hanine Medani, Karzan Hama, Mike Smith-Howell, Rajeev Kaushal, Shahzad Ahmed, Shan Chetiyawardana, V Gajek, Pugazhenthi Pattu, Ali Mahmmod, Lorraine Carter, Annette Fleet, Elizabeth Kemp, Jennifer Moyes, Gill Bell, Jo Burns, Katy English (nee Parkes), Sarah Hathaway-Lees, Ann Adams, Clare Mewies, Helen Cox, Helena Cox, Jacqueline Elliott, Alex Martin, Yvonne Rimmer, David Matter, Fred Tuck, John Raja Ravendar, Mark Heath, Amanda Neal, Jill Thain, Lisa Patterson, Rachel Stocking, Susan Hale, Yvonne Field, Deborah Clements-Dimmock, Frances Flynn, Joanne Kellett, Elizabeth Devoy, Gill Brett, Helen Small, Tracey Murray, Cathryn Woodward, James Curtis, Cherri Blades, Mau-Don Phan, Sonya Goriah, Sandra Griffiths nee Evens, Bryan Phillips, Bleddyn Edwards, Meena Raj, Ann Hewins, Samantha Coetzee, Rocio Riba, Zohra Omar, Gin Lee, Andrew Styling, Hossameldin Attia, James Jones, James Tanner, Kamarul Zaki, Mirela Hategan, Nicola Thompson, Sian Pugh, Simon Pacey, Danish Mazhar, Han Wong, Luke Hughes-Davies, Richard Benson, Kate Beesley, Safaa Therese, James Watson, Matthew Stone, Isaac Opara, Amy Strong n.Chandradass, Jane Bushen, Sandra Cunningham, Svitlana Iyevkova, Tatiana Hernandez, Anita Chhabra, Abigail Frost, Carole Hewitt, Ellie Couch, Gemma Cullen (née Godsall), Rachel Lister, Rebecca Bradley, Amanda Walker, Debra Mansergh, Glynn Rolland, Vanessa Moreira, Jessica Little, Jennifer Turner, Jennifer Turner, Jessica Little, Albert Edwards, Charlotte Mott, Fiora Elwes, Ifigenia Vasiliadou, Ilyas Ahmed, Ioannis Trigonis, Jennifer Turner, Jessica Gough, Lavarniya Rajakumar, Mathini Sridharan, Patryk Brulinski, Rakesh Raman, Rohit Malde, Sarah Beasley, Stephane Tankoua, Alice Rendall, Arafat Mizra, Carys Thomas, Christos Mikropoulos, Clary Evans, Gemma Hegarty, Jessica Little, Joao Galante, Kannon Nathan, Kathryn Lees, Mathilda Cominos, Matthew Fenton, Mohammed Osman, Natasha Mithal, Sharon Beesley, Sugeeta Sukumar, Udaiveer Panwar, Van Sim, Coral Greenstreet, Hayley Blackgrove, Katy Taylor, Victoria Williamson, Natalie Catt, Arafat Mirza, Sam Gibson, Steve Dann, Andrew Gillian, Miguel Capo-Mir, Cindy Slater, Diane Long, Hasmath Marjolin, Laura Mould, Nikki Crisp, Rachel Larkins, Sandra Holness, Sarah Lines, Susan Rogers, Claire White, Julie Buckley, Laura Kehoe, Lesley Rose, Louise Gladwell, Sarah Lightfoot, Tracy Boakes, Alba Tubau, Bonny Appleby, Caroline Sunderland, Carolyn Hargreaves, Linda Wray, Louise Allen, Marian Wood, Adedolapo Sanni, Claire Pelham, Elizabeth Williamson, Hilary Zurakovsky, Jill Baker, Joanne Williams, Julie-Ann Davies, Karen Robinson, Kathleen Walsh, Kim Mears, Kim Travis, Margaret Lipsham, Paula Whichelo, Sharon Middleton, Sue Kelly, Susan Drakeley, Sydnie Loveland, Molua Young, Denise Crawford, Aida Hanim Kamarudin, Alok Chand, Andrew Kidd, Clair Brunner, Lisa Victoria Jane Clayton, Michael Button, Nida Hassan, Satish Kumar, Srijith Sashidharan, Diana Mort, Jacob Tanguay, Jason Lester, Jim Barber, John Staffurth, Louise Harris, Nachiappan Palaniappan, Elizabeth Bois (nee Harris), Emily Rumney, Emma Cook, Naomi Woods, Rebecca Mitchell, Sandra Greenslade, Christian Smith, Gareth Hunt, James Morgan, Krishna Narahari, Phillip Morgan, Rashmi Jadon, Robert Henley, Ross McLeish, Toby Hiscott, Kevin Pearse, Michael Brown, Richard Coulthard, Amanda Jcekia, Gillian Willetts, Helen Clark, Helen Clark, Jayne Richards, Lynda Holman, Samantha Holliday, Tracy Rees, Caroline Vitolo, Clare Geere (nee Jones), Hana Thomas, Kay Wilson, Lynne Harry, Alison Johnson, Catherine Sullivan, Clare Donnithorne, Colette Clements, Colette Kemp, Debbie O'Connor, Gladys Makuta, Jessica Dermott (nee Platt), Joanne Preece, Lisa Stafford, Loretta Sweeney, Louise Morgan, Lucy Chestney, Necia Jones, Renata Poole, Sarah Fry, Sonya Osborne, Amanda Jackson, Bethan Tranter, Catherine John, Cathy Richards, Charlotte Young, Clare Boobier, Donna Lear, Karen Pow, Kathy Bishop, Leanne Quinn, Lucy Wilbraham, Vicki Reynolds, Howard Kynaston, Malcolm Mason, Lynette Lane, Fiona Douglas, Anil Kumar, Fergus Young, Jonathan Nicoll, Muhammad Rahman, Norma Sidek, Jenna Wildey, Christopher Brewer, Ivor Hughes, Beverley Wilkinson, Patricia Nicholls, Charlotte Eyles, Grace Fryer, Angela Birt, Diane Donnelly, Isabella Maund, Abdel Hamid, Gopalakrishnan Srinivasan, Kiran Kancherla, Priscilla Leone, Udaiveer Panwar, You Yone, Jennifer Child, Emma Mitchell, Amon Wijunamai, Dane Goodere-Bennett, Bryan Singizi, Christian Barnett, Melanie Boxall, Melanie Ruben, Victoria Apps, Donna Briggs, Emma Cannon, Jane Giles, Elizabeth Dawson, Emma Cannon, Lucy Willsher, Nicola Cutmore, Victoria Scott, Edel Spruce, Frances Cairns, Lucy Cooper, Sarah Ferguson, Sian Gibson, Yvonne Lester, Tracey Camburn, Enca Parsons, Caitlin Bowden, Laura Malins, Sai Jonnada, Victoria Bell, Vishal Bhalla, Alex Williams, Audrey Cook, Duncan Stow, Jo Bowen, Jyothsna Chennupati, Peter Jenkins, Roger Owen, Amy Skelton, Bethan Cartwright, Louise Kidner, Lucy Blake, Madelaine Smith, Sarah Stanley, Rachel Carter, Sarah Beazer, Matthew Tan, Samuel Croly, Ian Ingledew, Richard Wallis, Helen Babbage, Jennifer Dewett, Jennifer Smith, Jill Chittock, Julia Hall, Julie Allen, Lin Crossley, Nicola Robinson, Rachel Durrant, Rachel Sayers, Chris Ford, Kate Trigg-Hogarth, Sue Wronski, Susan Anderson, Abi Stuart, Charlotte Ayrton, Elaine Sizer, Elisabeth Read, Rebecca Mesher, Catherine Stuart-Grumbar, Janet Forkes, Jennifer Healey-Mariano, Rehana Bakawala, Azman Ibrahim, Elizabeth Gallimore, Emma Barry, Grace McGrath, Jenny Miller, Lucy Beresford, Shannon Spicer, Joshua Williams, Judith Prince, Wesley Artist, Chelcie Faulkner, Helen Jeffrey, Jenny Grounds, Kathryn Cawley, Rebecca Grogan, Rebecca Hopcroft, Sarah Illingworth, Sue Green, Helen Eccleson, Denise Archer, Janet Spriggs, Lisa Dobson (nee Child), Mary Aldous, Dirk Kienle, M Mark, Michael Schwitter, Raeto Strebel, Richard Cathomas, Roger von Moos, Carin Aebli, Eloise Kremer, Gabriela Manetsch, Radmila Moudry, Anita Szita, Muthar Kumar, Muthar Kumar, Sunil Skaria, Bruce Sizer, Bruce Sizer, Dakshinamoorthy Muthukumar, Devy Basu, Devy Basu, Rana Mahmood, Nicola Taylor, Pugazhenthi Pattu, Richard Gant, Louies Mabelin, Liz Hunting, Liz Hunting, Lucy Thorogood, Lucy Thorogood, Katrina Cooke, Michelle Fisher, Nicola Cutmore, Celine Driscoll, Celine Driscoll, Daisuke Takeuchi, Hayley Hewer, Hayley Hewer, Jane Ketley-O'Donel, Jane Ketley-O'Donel, Lorna Dewar, Michelle Marshall, Michelle Marshall, Carmel Loughrey, Robert Keating, Dulani Ranatunge, George Bozat, Iqtedar Muazzam, Jenny Marsden, Khawaje Zahid, Louise Karsera, Mohan Hingorani, Faheem Bashir, Mateen Akhtar, Mohammad Butt, Bob Bush, A Yousuff, Adam Wolstencroft, Ian Beckley, John Hetherington, Jonathan Gill, Kristian Plowman, Matthew Simms, Karen Stubbs, Linzi Bone, Paula O'Reilly, Julie Rawlings, Lucy Richardson, Mary Garthwaite, Sarah Moffat, Suzy Bunton, Carol Hodson, Linda Hoggarth, Sarah Brown, Sarah Palmer, Vicki Lowthorpe, Michael Tilby, Shah Rafique, Andrew Chan, Andrew Stockdale, Jane Worlding, Joanna Hamilton, Senthil Kumar Athmanathan, Yakhub Khan, Fiona McGurk, Lucy Miller, Mariam Bharuchi, Rajbinder Deol, Vicky Sturgess, Donald Macdonald, Mohamed Mooradun, Mohammed Khan, Albert Mislang, Jason Allen, Karandeepu Pachoo, Kieran Jefferson, Mark Whitmore, Sukhbinder Salh, Kathleen Rose, Kathleen Rose, Laura Stanley, Leila Fortunato, Noor Ayesha Shah, Zoe O'Neill, Elaine Simmons, Rachel Bazeley, Sonia Powell, Theresa Griffiths, Vikki Browne, Charlie-marie Suddens, Dannielle Burgess, Fiona Tranter, Jenny Warmington, Luanne Carey, Padama Singh, Sarah O'Toole, Stacey Clarke, Su Ngwenya, Sue Robinson, Tammi-Lea Beeby, Linda Wimbush, Maggie Brown, Rachel Thompson, Rebecca Aaron, William Croxford, Anna Tran, Catherine Thompson, David Butterworth, James Wylie, Michael Braun, Adele Hough, Annabel Tomlinson, Gemma Nash, Karen Hillyer, Katherine Hampton, Sarah Tinsley, Andrew Ritchings, Osman Chohan, P Irwin, P Javle, Carole Bennion, Caroline Walker, Joanne Hughes, Julie Meir, Karen Wilson, Kim Best, Leanne Everall, Lydia Buxton, Nicola Ritchings, Chris Hough, Bethan Roberts, Emma Margerum, Jane Sellman, Karen Gilbert, Rachel Smith, Taya Jones, Thiraviyam Elumalai, Tracy Larcombe, Carolyn Mansfield, Julia Gemmell, Sarah Hoswell, Vanessa Adamson, Yvonne Campbell, Ann Payne, Anne Haldeos, Cheryl Batish, Mohammed Kagzi, Clive Peedell, John Hardman, Julia McBride, Steven Pratt, Tanmay Mukhopadhyay, Rachel Chatt, Jonathan Stoddard, Richard Nendick, Calum Polwart, Hyder Latif, John Vickers, Asia Sarwar, Helen Haley, Kimberly Stamp, Lynsey Stephenson, Alison Chilvers, Claire Henderson, Susan Wadd, Lorna Morgan, Fiona Strong, Jane Shaw, Penny Gamble, Louise Lacey, Christopher Kent, Ajith Gopinathan Nair, Alastair McCabe, Ayman Ramadan, Chin-Hiong Chong, Jun Hao Lim, Kiran Das, Lauren Jones, Maeve Pomeroy, Peter Mason, Sadia Abdullah, Seheli Bandyopahdyay, Thangarajah Mugunthan, Timothy Podd, Virgil Sivoglo, Christopher Kent, Dakshinamoorthy Muthukumar, Dakshinamoorthy Muthukumar, Jessica Davies, Lokesh Puttarachaiah, Louise Brookes, Mike Smith-Howell, Prabir Chakraborti, Prabir Chakraborti, Prantik Das, Rania Mohammed, Sarah Taylor, Sathan Boonyaprapa, Shahzad Ahmed, Caroline Coulson, Georgia Wright, Helen Beveridge, Marie Ann Goldsworthy, Heini Jussila, Keeley Smith, Chris Worth, James Aldous, Pugazhenthi Pattu, Aaron Gallagher, Colin Ward, Colin Ward, Fanuel Magaya, Alison Carrick, Charlotte Downes, Donna Beal, Elizabeth Nadin, Joely Morgan, Kashmira Subramanian, Margaret Harper, Wendy Morrisroe, Wendy Morrisroe, Elizabeth Bedford, Ellie Piggott, Josephine Chmiel, Liz Bedford, Lucy McCandless, Manni Sandhu, Nicole McKee, Nicole McKee (nee Isitt), Wendy Abbott, Claire Wintle, Emily Mignott, Emma Brooks, Hege Strand, Janet Tomlinson, Jennifer Mitchell, Jodie Fitzgerald, Julie Edmonds, Sarah Hathaway-Lees, Sarah Longhurst, Debbie Davis, Gemma Irvine, Gemma Redfern, Jane Lawrie, Julie Dockree, Karen Simmonds, Karen Simmonds, Kay Bowdler, Kristina Duggleby, Lorraine McDonald, Mishelle Fanuncio, Sarah Hare, Sarah Hare, Shobha Saravanasuthan, Sonya Bradshaw, Susan Smith, Anna Lydon, Jessica Tay, Muneeb Qureshi, Pooja Iyer, Virgil Sivoglo, Carmel Pezaro, Catherine Ferguson, Georgia Hooton, Janet Field, Jennifer Taylor, Alexandra Firth, Robert Chadwick, Ben East, Amy Neal, Deborah Walstow, Lisa Warren, Meredyth Harris, Nicola Wilkinson, Nicole Jeffcutt, Sharon Ann Allen, Janine Smedley (nee McCabe), Joanne McNally, Rachel Codling, Barbara Burlace, Joanne Derx, Laura Ellis, Lucy Smith, Sarah Brown, Kim Wood, Benjamin Masters, Perric Crellin, Kate Taylor, Ananda Chakrabarti, Andrew Rees, Naveed Afzal, Robert Blegay, Stephen Andrews, Andrew Cornaby, Andrew Gibbins, Piet Bakker, Simon Sharpe, Louise O'Shea, Sally Love, Sarah Williams, Susan Carr, Jackie Gibbins, Josie Goodsell, Beverley Anderson, Delia Whiteman, Laura Bough, Stephanie Jones, Tracy Glen, Lynn Billett, Pauline Ashcroft, Sally Breakspear, Sarah Horton, Suzy Wignall, Helen Robertshaw, Georgi Georgiev, Joseph Mano, Pek Keng-Koh, Syed Tirmazy, Abel Zachariah, Mano Joseph, Prakash Ramachandra, Emily McDonald, Joann Atkinson, Julie Matthews, Andrew Moores, David Edwards, Lawrence Emtage, Manesh Patel, Paul Anderson, Irene Gardner, Vanessa Moore, Ruckie Kahlon, Anna Summerfield, Ellen Shirley, Heather McClure, Karen Pearson, Nadira Jilani, Angela Watts, Dee Harris, Ellie Traverse, Hayley Pearson, Jayne Kanwar, Jenny O'Grady, Karen Kanyi, Karen McGarry, Lesley Edwards, Lucie Smith (nee Williams), Sally Keates-Porter, Sara Smith, Kath Harrow, Sangeetha Ponnusamy, Sarah Welsh, Rhona McMenemin, Andrew Parker, Lorna Morgan, Dorothy Turnbull, Jean Dent, Jeanette Maughan, Julie Elliot, Julie Elliott, Nicky Naraine, Graham Watson, Aspasia Soultati, Caroline Manetta, Caroline Manetta, Duncan Gilbert, Duncan Gilbert, Fiona McKinna, Peter Rimington, David Sharp, Mark Whitfield, Neville Sharma, William Lawrence, Jo-Anne Taylor, Kay Jones-Skipper, Angie Bowey, Lauren McCrisken, Prudence Hobbs, Shelley Baumber, Theresa Baumber, Joanna Howard, Alistair Law, Amy Cooper, Dr Aravindhan Sundaramurthy, Archie Macnar, Caroline Bruce, Mark Stares, Martin Doak, Olvsola Faluyi, Claire Arthur, Duncan McLaren, Ewan Brown, Grahame Howard, Hannah Lord, John McGrane, Katie Wood, Sanjana Masinghe, Emma Lewis, Heather Howie, Nikki Gilluley, Ben Elliott, Jahangeer Malik, Richard Allan, Roland Donat, Alan McNeill, Brian Rogers, David Jeffrey, David Tulloch, Prasad Bollina, Lynn Ho, Vivienne Wilson, Barbara Mayne, Alison Clark, Alison McKinlay, Beverley Mitchell, Catherine Woods, Jennifer Baxter, Kirsty Peebles, Sarah Thompson, Tracy Brear, Ailsa Liddle, Andrea Stanton, Ann Cochrane, Fiona Gardiner, Fionagh Ross, Hazel Milligan, Heather Dalrymple, Heather McVicars, Lisa Egan, Lois Pollock, Susan Forman, Theresa Savage, Anna Thompson, Lucinda Melcher, Mausam Singhera, Nishi Gupta, Stephen Karp, Ursula McGovern, Ayesha Ahmed Surti, Chloe Van Someren, Sagal Kullane, Girish Bhome, Tom Caumont, Tessa Light, Kerri Rees, Beatrice Balachandran, Bernadette Collins, Ferrial Syed, Kathy O'Farrell, Pauline Lee, Ayman Nassar, David Jonathan Chambers, Lyndon Ridges-Jones, Mohini Varughese, Natalie Nityey, Peter Stephens, Shiv Uppal, Victoria Ford, Anne Hong, Denise Sheehan, Elizabeth Toy, Rajaguru Srinivasan, San Aung, Tim Norris, Ceri Davies, Eleonor Brown, Grace Justice, Kerri-ellen Oakley, Sophie James, Stephanie Ann Ellis, Theresa Lawless, Susan Downer, Alan Betts, James Leavy, Matt Trivett, Petar Hitev, Christoph Lohan, John Anderson, Ross Curwen, Elaine Vandcandelaere, Emma Guerin, Frances Hood, Melissa Davey, Alison Augstburger, Claire Webb, Emma Robjohns, Ingrid Seath, Kate O'Connor, Alison Roantree, Jane Piper, Rosie Mew, Sophie Warren, Susan Davenport, Tracey Foss, Beverley Kemp, Claire Ridler, Dawn Edwards, Elizabeth Davey, Fiona Walters (nee Hall), Kizzy Baines, Lyndel Moore, Shirley Todd, Suzy Tasker, Tamika Chapter, Natalie Charnley, Natalie Charnley, Hazel Aston, Afroditi Karathanasi, Diletta Bianchini, Stergios Boussios, Swapna Thomas, Charlotte Abson, Christos Mikropoulos, Henry Taylor, Tessa Lawrence, Agne Sadauskaite, Corinne Borley, Durga Maya Gurung, Jodie Seymour, Mary Everett, Charles Davis, James Sawyer, Kevin Naicker, Khalid Abdalla, Peter Milverton, Philip Adeniran, Simon Wan, Parool Darbar, Richard Thornton, Alba Tuban, Alison Richards, Clarissa Madla, Deirdre Cooke, Elizabeth Newman-Horne, Gayzel Vallejera, Katarzyna Urbanczyk, Kay Jones, Lisa Parker, Louise Black, Louise Brassington, Marie Louise Hollands, Nicola Southwell, Emma Sutton, Judy Filmer, Suzie Reyner, Adedolapo Sanni, Carol Mayger, Tamara Diamond, Aisha Tufail, Almudena Cascales, Ashleigh Kerr, Brendan McCann, Cicely Cunningham, Derek Grose, Ian Sanders, Jawaher Ansari, Kathryn Banfill, Miranda Ashton, Rebecca Muirhead, Stephen McKay, Abdulla Al-hasso, Aqilah Othman, Awris Jalil, Azmat Sadozye, Balaji Venugopal, Ben Fulton, Carolynn Lamb, Christina Wilson, David Dodds, Esfandiyar Khan, Hilary Glen, Husam Marashi, Jan Wallace, Janet Graham, John Graham, Kathryn Graham, Lye Mun Tho, Martin Russell, Maryon Hardie, Mohammed Alfayez, Nicholas Macleod, Norma Sidek, Patricia Roxburgh, Paula Henry-Stephenson, Rana Mahmood, Rob Jones, Sally Hall, Saranya Kakumanu, Sophie Barrett, Stefan Nowicki, Tareq Abdullah, Diann Taggart, Katie Galbraith, Nicola Cairns, Gerard Forrest, Calum Innes, Graeme Lumsden, Martin Ball, Nathan Richardson, Ross Carruthers, Hannah Weir, Linzi Rae, Maureen Connolly, Ailsa Griffen, Jacqueline Gourlay, Jan Graham, Karen Bell, Alice Coy, Gemma Johnson, Gillian Barmack, Jennifer Petrie, Annette Charlick, Antonia MacMillan, Catriona Cowan, Claire Steele, Fiona McQueen, Jenny Brown, Judith Dixon, Kirsteen Stuart, Kirsten Laws (nee Borthwick), Lorraine Barwell, Louise Bruce, Lynne Grieve, Maria Nicol, Patricia Baird, Ruth Orr, Sai Juan Jia, Laura Malins, Sai Jonnada, Victoria Bell, Audrey Cook, Jo Bowen, Peter Jenkins, Roger Owen, Amy Skelton, Bethan Cartwright, Sarah Stanley, Sarah Beazer, Samuel Croly, Richard Wallis, Julia Hall, Julie Allen, Lin Crossley, Rachel Sayers, Chris Ford, Kate Trigg-Hogarth, Sue Wronski, Abi Stuart, Charlotte Ayrton, Claire Salter, Elaine Sizer, Elisabeth Read, Louise Moore, Sarah Matthews, Janet Forkes, Carla Perna, Emmanuel Larbi, James Lowe, Leslie Cheng, Mahwish Karim, Melanie Boafo-Yirenkyi, Sara Khaksar, Charlotte Shelley, Jenny Nobes, Joanna Stokoe, Julian Money-Kyrle, Katie Wood, Katie Wood, Mahomed Moosa, Maria Drzymala, Richard Shaffer, Robert Laing, Sree Susaria, Teresa Guerrero-Urbano, Imogen Heenan, Kavita Bhat, Lesley Harden, Nick Pilkington, Richmond Abeseabe, Angela Morgan, Miriam White, Adele Hugg, Caterina Bissa, Jane Woods, Julie Wilkinson, Veronica Davis, Frances Sidi, Jen Julius, Julia Whittle, Kate Penhaligon, Kathrin Narvaez-Vega, Lucinda Scott, Marianne Dabbs, Stephy Joseph, Catherine Medcalf, Celia Harris, Daisy Floyd, Fiona Butler, Linda Nardone, Sarah De Swert, Sue Sargent, Teresa Keating, Zephyrine King, Miranda Usher, Lisa Gledhill, Carrie Lowthian, R Bradford, Albert Edwards, Hamoun Rozati, Paul Kabuubi, Shroma De Silva, Tasia Aghadiuno, Zainab Wasim, Anna Lerner, Lucinda Melcher, Nishi Gupta, Reena Davda, Reena Davda, Nikki White (nee Staines), Sylwia Goliaszewska, Ahmed Hnoosh, Ervin Shpuza, Sunjalee Fernando, Cait Rees, Amanda Lewis, Amelia Daniel, Amy Lewis, Gemma Cook, Hana Malinkovicova, Joanne Kellaway, Tracey White, Evelyn Holmes, Jodie Johnson, Teresa Light, Sandra Griffiths nee Evens, James Wakelin, Jane Gibbard, Leigh Burns, Sandie Wellman, Caitlin Bowden, Cara Watson, David Stow, Timothy Spencer, Vishal Bhalla, Warren Grant, Audrey Cook, Duncan Stow, Maxine Flubacher, Nina Reeve, Bethan Richards, Jolanta Pueskacz, Linda Moseley, Lisa King, Nicola Williamson, Sarah Chapman, Serrafina Carini, Sophie Cooper, Stacey Turner, Harriet Taylor, Jagdish Chana, Terry Watson, Andy Hedges, Amanda Davies, Isabel Martin (Whitehouse), June Thomas, Laura Lees, Melanie Evans, Rebecca Bengree, Susan Anderson, Zara Roberts, Bethany Wellington, Janine Jones (Birch), Naeem Musani, Susan Anderson, Caroline Thomas, Catherine Reed, Claire Hughes, Gill Horsfield, Jenny Howls, Kate Hammerton, Rachel Lowe, Sophie Boyd (nee Evans), Anita Ashton, Janet Forkes, Sophie Boyd, Rachel Low, Ami Sabharwal, Avinash Gupta, Janice Carpenter, Katherine Hyde, Thinn Pwint, Benjamin Fairfax, Gerard Andrade, Niki Panakis, Philip Camilleri, Prabir Chakraborti, Sally Trent, Sean O'Cathail, Vivek Mohan, Wasiru Saka, Chrissie Butcher, Chrissie Butcher, Claire Fernandez, Amarjit Bdesha, Moncy Mathew, Neil Haldar, Rahul Kurup, John Patrick Kelleher, Neil Trew-Smith, Alice Ngumo, Anita Cserbane, Gail Varley, Janet Weir, Manisha Joshi, Penny Carter, Siobhan Gettings, Maggie Aldersley, Michelle Taylor-Siddons, Tracey Stammers, Ans-Mari Bester, Aruna Nair, Catherine Northey, Emma Hogbin, Erica Lieberman, Helena Stone, Kathryn Herbert, Rossana Mancinelli, Samantha Thomas, Sarah Manyangadze, Susan McLain-Smith, Tiffany Chan, Bhavna Badiani, Bhavna Badiani, Christine Collins, Evelyn Chan, Hazel Wynn, Ileana Nguyen, Jasvinder Bains, Nicola Bowers, Roisin Kavanagh, Andrew Protheroe, Omer Babiker, Rob Turner, Samantha Turnbull, Barbara Crosse, Emma Woodward, Jane Hook, Uschi Hofmann, Hannah Riley, Sanya Anjum, Sarah Hanley, Adam Mawer, Deivasikamani Ramanujam, Mohammad Irfan Alam, Nicolas Bryan, Hayley Webster, Julie Millward, Kathryn Smith, Kully Sandhu, Lear Matapure, Lee-Ann Bayo, Melanie Quesne, Nicky Daker, Hayley Inman, Lisa Shaw, Miranda Usher, Belinda McLean, Diane Kelly, Karen Bicknell, Katherine Tighe, Lindsay Greenhalgh, Lucy Jones, Monica Narasimham, Naledi Mzwimbi, Paula Gomes, Christine Turner, Denise Hancock, Lisa Gledhill, Mandy Madigan, Rachel Parker, Sharon Woolley, Stacey Freeth, Tracy Wood, Ibrar Hussain, Christopher Hamilton, Robert Dealey, Emma Bertram, Sarah Moffat, Suzy Bunton, Claire Levesley, Linda Hoggarth, Ramachandran Subramaniam, Neil Fisher, Alison Nicholls, Anne Marie Pollock, Charles Kodikara, Feng Yi Soh, Marion Paterson, Neil McPhail, Sin Ting (Amy) Chan, Aristoula Papakostidi, Azmat Sadozye, Carol Macgregor, David Whillis, Kay Kelly, Martin Russell, Steve Nicholson, Denise Campbell, Graeme Jervis, Ian Shread, Michael Loynd, Jude Madeleine, Sean Neville, Sudhir Borgaonkar, Anglise Addison, Karina McQuiston, Mary McKenzie, Melanie McIlroy, Rachel Mackay, Una Taylor, Alison Macdonald, Angela Macgregor, Florence Anderson, Georgina Simpson, Jane Campbell, Sandra Brown, Seonaid Arnott, Anna Robertson, Anna Skene, Jane Sinclair, Joan Stewart, Karen Callum, Laura Maclennan, Margaret Chisholm, Melissa Lynch, Zoe Urquhart, Audrey Campbell, Catriona Morrison, Fiona Campbell, Glenda Sinclair, Susan Bain, Deborah Abrams, Kevin Redshaw, Sam Obay, William Ine, Adiba Hoodbhoy, Christopher Scrase, Jennifer Collins, Ramachandran Venkitaraman, Sarah Treece, Sheen Cherian, TJ Podd, Debbie Austin, Andy Dann, Chris Rose, Joe Wells, Matt Mendoza, Gautam Banerjee, Ian Floodgate, John Parry, Mohsen Habib, Paul Ridley, Peter Donaldson, Robert Brierly, Charlotte Etheridge, Karen Bass, Kerry Howlett (nee Brown), Mandy Riley (nee Evans), Susan Teh (Seok San), Sonia Kerridge, Susan Upson, Yvonne Tricker, Harriet Williami, Jo Woor, Julie Simpson, Angharad Williams, Julie Spurgeon, Natalie Lloyd, Elizabeth Harrison, Ann Henry, Charlotte Richardson, Clara Sentamans, Nathalie Casanova, Simon Brown, Sohail Mughal, Dan Lee, Ganesan Jeyasangar, Michael Crawford, Sue Cheeseman, Amy Pendrill, Andrew Gash, Joseph Quinn, Satti Saggu, Carl Booth, Anita Ratcliffe, Josie Snell, Lisa Bullough, Liz Shenton, Pip Hill, Rachel Kennedy, Sharron Parkinson, Alison Shaw, Gillian Darnbrook, Jasmine Hartley, Alison Swindells, Hayley Bates, Louise Binns, Ruth Johnson, Fiona Farquhar, Helen Henson, Judy McAlister, Maxine Briggs, Mandy Swanepoel, Ayyaz Munawar, Kirsty Clarke, M Habib Khan, Shaikh Rana, Lisa Capaldi, Mark Churn, Paul Flinders, Hugh Morrow, Monica Gauntlett, Veronica Rowlands, Emma Marshall, Hayley Hodson, Helen Tranter, Julie Wollaston, Kate Field, Patricia Rimell, Sarah Moss, Sally Stringer (pr. Davis), Alison Rosoman, Jayne Tyler, Linda Higgins, Ricky Hunter, Jennifer Keith, Margaret McKernan, Maureen Templeton, Sophie Raby, Adam Peters, Amy Martin, Caroline Lowrie, John Martin Russell, Saurabh Borgaonkar, Stephen McKay, Carolynn Lamb, Nadja Melquiot, Norma Sidek, Eilidh Henderson, Kirsty Young, Mhari TTaylor, Stephanie Brogan (nee Roddie), Seamus Teahan, Anna Hamilton, Anne Todd, Joanne Robinson, Lesley Symon, Patricia Turner, Lynn Prentice, Maureen Hamill, Sally Young, Alison Yule, Maureen Hamill, Geert Van Driessche, Benangene Midez, Angela Orcurto, Antonella Diciolla, Claire Perrinjaquet, Dominik Berthold, Louis Parisod, Sofiya Latifyan, Fernanda Herrera, Akram Farhat, Yohan Boillat, Alexandra Rideau, Fabrice Lalubin, Hans-peter Roth, Jean-Philippe Zurcher, Tewfik Abedlaziz, Kaniana Ntanga Muambayi, Sandra Toffanin, Agnes Hiou Feige, Alice Abdallah, Aline Voidey, Anabela Costa, Anna-Sophia Briod, Carmen Castagna, Catherine Bender, Celine Yerly, Cosette Schuler, Cynthia Leclerc, Eloise Kremer, Floriane Bouilly, Margaret McLauchlan, May-Lucie Meyer, Nathalie Divorne, Nicole James Faresse, Norlene Silva, Rebecca Oppenheim, Sophie Voegtlin, Sylvie Haudidier, Veronica Aedo, Patrice Jichlinski, Galaad Bernard, Marc Schnety, Sabine Galland, Sophia Murel, Ann Henry, Ann Henry, Christopher Williams, Christy Ralph, Ee Siang Choong, Emma Dugdale, Ian Boon, Joseph Joji, Katy Clarke, Katy Clarke, Michael Flatley, Naveen Vasudev, Anne Kiltie, Anne Kiltie, Carmel Loughrey, David Bottomley, Hima Bindu Musunuru, Janet Brown, John Chester, Kevin Franks, Krishna Shastry, Lisa Owen, Luis Daverede, Richard Khafagy, Satinder Jagdev, Claire Posnett, Hannah Roberts, Javeria Akhtar, Jodene Hill, Judith Evans, Svetoslava Doshmanonska, Liz Hudson, Christopher Main, Ruiyang Yan, Sanjeev Kotwal, William Cross, Adrian Joyce, Adrian Joyce, Alan Paul, James Cavanagh, Peter Whelan, Rafal Turo, Sam Lotfi, Stephen Prescott, Sunjay Jain, Catherine Parbutt, Jude Clarke, Lorraine Wiseman, Polapo Ajayi, Angela Morgan, Anne Crossley, Dolapo Ajayi, Hannah Wigginton, Lorraine Wiseman, Caroline Bedford, Caroline Bedford, Charlotte Pool, Emily Davies, Emma Lundy, Gemma Austin (nee Glover), Helen Payne, Jade McCann, Judith Chapman, Maria Hall, Mercy Kaiga, Sue Rodwell, Sue Sibson, Richard Kaplan, Richard Kaplan, Eloise Kremer, Simone Marini, Vanessa Fuhrer, Andreas Lohri, Ana Fernandez-Ots, Andrew Sloan, Christian Arias, David Ballesteros-Quintail, Elena Macleod, Sindhu Ramarwothy, Yogesh Nishchal, Alfredo Addeo, Karin Baria, Miguel Panades, Prantik Das, Thiagarajan Sreenivasan, Thiagarajan Sreenivasan, Gunjan Phalod, Andrew Judd, Ray McDermott, Stephen Audu, Simon Archer, Alyson Wilson, Diane Carey, Kathryn Pearson, Kerri Johnson, Laura Walsh, Maryanne Okubanjo, Olesya Francis, Caroline Taylor, Suzanne Archer, Giuseppe Banna, Helen Carolan, Janet Tomlinson, Jayne Borley, Jenny Salmon, Kathryn Hoare, Rebecca Spencer, Rhiannan Pegg, Sarah Bell, Sarah Coombs, Stephanie Barker, Annette Hilldrith, Carol Lockwood, Rachel Newton, Susie Butler, Jasima Latif, Chinnamani Eswar, Paul Hill, Peter Robson, Peter Robson, Zafar Malik, Lucy Berresford, Rachael Fergusson, Katy Treherne, Kevin McDonald, Paul Griffiths, Philip Reynolds, Wesley Artist, Lorraine Lancaster, Nidhi Sibal, Sharon Dunn (nee Johnson), Sue Green, Sandra Robinson, Sandra Robinson, Nicola Bermingham, Pembe Yesildag, Dawn Porter, Haley McCulloch, Julie Griffiths, Julie Griffiths, Leigh Pauls, Lisa Dobson (nee Child), Lisa Dobson (nee Child), Lizzie Dale, Pauline Pilkington, Adnan Akhtar, Ajay Aggarwal, Anita Mitra, Anna Wilkins, Anuradha Jayaram, Bianca Tryillo, Bihani Kularatne, Caterina Aversa, Cavitha Vivekananthan, Chara Stavraka, Charalampos Gousis, Charleen Chan Wah Hak, Clare Gilson, Deborah Enting, Delali Adjogatse, Dieo Ottaviani, Eirini Tsotra, Eleni Josephides, Elias Pintus, Elias Pintus, Emily Durie, Emily Scott, Ewan Chapman, Gelareh Eslamian, Gianmarco Leone, Grant Stewart, Hannah Rush, James Lowe, Jana McHugh, Jennifer Turner, Kallol Bhadra, Kamarul Zaki, Karen Tipples, Kate Smith, Kiruthikah Thillai, Laura Camburn, Leron Okonta, Magdalena Kubiak, Maise Albakir, Mark Voskoboynik, Matthaius Kapiris, Mohammed Mahgoub, Muhammad Khan, Nicholas Vanas, Nicola Rosenfelder, Nikolaos Tsoukalas, Paul Kabuubi, Rosalind Kieran, Roxane Mather, Ruochen Li, Sabeeh Butt, Sarah Howiett, Sarah Needleman, Stephen Mangar, Stephen Mangar, Stephen Mangar, Stephen Morris, Thomas Bird, Thubeena Manickavasagar, Tzveta porrovska, Vedang Murthy, Vinod Mullassery, Vinod Mullassery, Vishal Manik, Yin Wu, Alison Falconer, Alison Falconer, Alison Falconer, Alison Reid, Angel Garcia-Imhof, Anna Karpathakis, Archie Macnair, Arunansu Kar, Asim Ray, Daniel Smith, Daniel Tong, Danielle Crawley, Debra Josephs, Ethna Mannion, Farhad Neave, Hartmut Kristeleit, Hartmut Kristeleit, Heather Payne, Jackie Newby, Jason Chow, Jonathon Shamash, Judith Cave, Karen Chan, Katherine Pigott, Lawrence Krieger, Lisa Pickering, Lucy Juggins, Maria Vilarino-Varela, Mark Linch, Mehran Afshar, Naveed Sarwar, Nick Maisey, Paula Wells, Ramin Ajami, Reena Davda, Ronald Beaney, Rosalind Eeles, Rushan Sylva, Sarah Hargreaves, Sarah Rudman, Sharmistha Ghosh, Sheeba Irshad, Simon Chowdhury, Simon Hughes, Simon Hughes, Simon Stewart, Sindu Vivekanandan, Sophie McGrath, Stephanie Gibbs, Stephen Harland, Susanne Allan, Teresa Guerrero-Urbano, Ursula McGovern, Uzma Asghar, Vasiliki Michalarea, Vincent Khoo, Wing-Kin Liu, Thomas Amoaten, Alice Dainty, Anita Soma, Asha Mistry, Claire Gilmartin, Eleanor Quinn, Emma Douch, Hannah Payne, Holly Hogan, Jennyfa Ali, Jessica Hunt, Kerry Richards, Kharishma Makani, Louisa McDonald, Martha Wilson, Nicola Lucas, Nicole Bonsu, Olivia Bolton, Samirah Rokib, Sarah King, Serena Dover, Sultana Begum, Tahereh Ghadimi, Uforma Ogrigri, Vijitha Vijayakumar, Vivien Quan, Melody Ncube, Abel Jalloh, Abhijit Jadhav, Antonio Querol-Rubiera, Declan Cahill, Fahim Ahmed, Fatjon Dekaj, Gareth Barker, Gareth Barker, Geoffrey Howell, Hakim Guessous, Ignacio Blanch, Jagdev Bains, Joel Watson, Jude Nixon, Juel Tuazon, Kristian Warnes, Li Wancheung, Luke Maidment, Michael Brown, Michael Moneypenny, Oscar Riches, P Cathcart, Rayhan Ahmed, Rayhan Ahmed, Rick Popert, Robert Varro, Ross Dalton-Short, Sam Hollingworth, Sebastien Martin, Simon Wan, Sumeet Sisodia, Vinod Mullessey, Alastair Nicholson, Bernard Sill, Bernard Siu, Chris Abbott, Danny Garrett, Gerry Trillana, Ilyas Ali, Jozer Calara, Kwame Ansu, Lee Porin, Mark Quarrell, Nigel Holmes, Philip Reynolds, Philip Reynolds, Steve Edwards, Steve Edwards, Steve Edwards, Thomas Sarkodie, Thomas Spencer, Trevor Bott, Trevor Bott, Adrienne Abioye, Joyce Maravi, Kaliyanee Ramtohul, Ngozi Muoneke, Nia Alsamarrai, Resmi Jayachandran, Roshni Goel, Ruth Stafferton, Samantha Chetiyawardana, Samia Pilgrim, Sarah Storrs, Zohanon Sabine Loko, Zohanon Sabine Loko, Andrea Davis-Cook, Andrea Davis-Cook, Chi Yee Chung, Debra Townsend-Thorn, Holly Baker (nee. Wing), Holly Baker (nee. Wing), Regina Storch, Sharon McPherson, Sijy Pillai, Aarti Nandani, Aarti Shah, Aarti Shah, Agnieska Zielonka, Aileen Austria, Anna Osadcow, Anne Haldeos, Anne-Marie Vindidu, Annette Musallam, Asma Varachia, Awo Abdi, Bindu Chikkamuniyappa, Bindu Chikkamuniyappa, Chandni Patel, Claire Glendon, Claire Jarvis, Deirdre Daly, Denise Humfress, Emma O'Connor, Eva Batovska, Eva Batovska, Giulia Carlino, Hannah Powell, Helen Stidwell, Helene Zilkha, Jane Gregg, Jane Leach, Javeria Akhtar, Jennifer Martin, Juliet Owusu, Kafui Dossa, Karen Brooks, Lexi Vick, Linda Shephard, Lorna O'Shea, Louisa Fleure, Marina Baccarini, Marisa Pinto Peixoto, Martha Handousa, Miriam Cottle, Nadia El-Sayed, Naomi Anderson, Natasha Aslam, Nicola Harman, Nikki Kettley, Rebecca Way, Sabina Melander, Sagira Khatun, Sally Walker, Severine Rey, Shahanara Ferdous, Shahreen Ahmed, Shanna Wilson, Susie Slater, Suzanne Chukundah, Suzy Lowi, Tesha Suddason, Theodorah Nago, Yemi Ilumoka, Akeema Paul, Akeema Paul, Angela Chamberlain, Angela McCadden, Anna Parker, Annelies Gillesen, Belinda Chitando, Belinda Chitando, Bridget Kabagambe, Catherine Rogers, Cheryl Lawrence, Cheryl Lawrence, Chloe McCormack, Daisy Floyd, Daisy Floyd, Debbie Blois, Debbie Rolfe, Debbie Rolfe, Didem Agdiran, Donna Cassidy, Elizabeth Woodford, Emilia Caverly, Emily Pickford, Eti Omoregie, Francesca Curran, Gillian Hornzee, Hannah Ansell, Hazel Harrop, Helen Snow, Helen Tighe, Ibiyemi Sadare (Olaleye), Janet Kiff, Janet Oladimeji, Janette Nichol, Jennifer Morrison, Jill Gallagher, Joy Liao, Joy Liau, Judy Hill, Juniebel Cooke, Kate Williams, Laillah-Crystal Banda, Laura Beschizza, Laura Custins, Lorraine Hurl, Lucy Reed, Maria Liskova, Marisa Lanzman, Melloney Allnutt, Michelle Dutton, Najma Ahmed, Noan-Minh Chau, Patricia Danaswamy, Rachel Harper, Rebecca Todd, Ruth Johnson, Samantha Weller, Sara Fawcitt, Sharai Chitando, Sharon Clovis, Sophie Golden, Srivani Kandasamy, Stephanie Argue, Stephanie Steadman, Su Fung Lo, Sue Cromarty, Suraya Quadir, Suzanne Vizor, Temi Olusi, Ursula Kirwan, John Masters, Nicholas James, Peter Harper, Richard Kaplan, Amanda Clarke, Claire Baldry, Delali Adjogatse, Patryk Brulinski, Alicia Synowiec, Clary Evans, Emma Kipps, Henry Taylor, Jess Brady, Kathryn Lees, Matthew Fittall, Romaana Mir, Sharon Beesley, Amie Thomas, Anna English, Katy Taylor, Gavin Fossey, Ian Pamphlett, Alison Davison, Ann Phillips, Jane Murray, Louise Hooper-Gilham, Alison Richards, Carmel Jope, Clare Calvert, Jane Brown, Julia Sunnucks, Laura Clayton, Verity Roberts, Claudia Woodger, Emma Craske, Joanne Patterson, Joanne Williams, Lisa Tribe, Sarah Martins, Su Burrage, Vivienne Breen, Andrew Hudson, Ather Kazmi, Christoph Oing, Hebalalla Abdelaal, Martin Swinton, Robin Portner, Sreeja Aruketty, Stefanie Fisder, Stephen Chin, Yee Pei Song, A Jegannathen, Ananya Choudhury, Anna Bruzzan, Anna Tran, Beatriz Duran Jimenez, Beatriz Duran Jimenez, Catherine Coyle, Clara Chan, David Thompson, Jacqueline Livsey, James Wylie, James Wylie, John Logue, Michael Braun, Richard Cowan, Ruth Conroy, Shaun Tolan, Silke Gillessen, Tony Elliott, You Yone, Amber Hart, Anna Gipson, Charlotte Heywood, Kim Fair, Laura Flanagan, Maria Petsa, Samah Mughal, Sarah Green, Sarah-Ellen Ellen (née McCarthy), Tania Cutts, Willemijn Spoor, Alkesh Patel, Kamlesh Patel, Tony Elliott, A. Emara, Ali Al-Hashimi, Damian McCall, Damian McCaul, Ekugbe Onogbe, Ekugbe Onoge, Ian Bottomley, Vijay Ramani, Vijay Sangar, Helen Haydock, Vivienne Benson, Vivienne Benson, Kate O'Connor, Sue Davison, Annie Duffy, Annie Duffy, Catherine Pettersen, Claire McGuire, Humera Ahmed, Julie Fielding, Kathryn Fellows, Kathryn Slevin, Kirsty Melia, Linda Bailey, Linda Bailey, Lucy Worsley, Megan Bunce, Molly Bennett, Rebecca Corless, Roonak Nazari, salina tsui, Sarah Liptrott, Sharon Capper, Stephanie Hargreaves, Thiraviyam Elumalai, Trishna Uttamlal, Wendy Guest, Zhara Mahmood, Angela Chrisopoulou, Angela Gowrie, Anna Bowron, Catherine Redshaw, Catherine Redshaw, Cathryn James, Cathryn Jones, Emma Burke, Emma Lowther, Fiona Murtagh, Janet Smith, Jeanette Lyons, Joanne Oliver, Julie Bramley, Karen Robb, Lillian Partington, Lindsay Piper, Lindsay Piper, Lorraine Turner, Lydia Sutherland, Lynne Gilmore, Marie Woolley, Sarah-Ellen Smith, Sue Seifi, Susan Arrand, Tarnya Hulme, Thobekile Mthethwa, Thobekile Mthethwa, Tracey Platt, Tracey Platt, Noel Clarke, Jackie O'Dwyer, Viv Thomas, Albert Edwards, Charlotte Mott, Ifigenia Vasiliadou, Lavarniya Rajakumar, Mathini Sridharan, Patryk Brulinski, Rakesh Raman, Rohit Malde, Stephane Tankoua, Arafat Mizra, Carys Thomas, Clary Evans, Kannon Nathan, Kathryn Lees, Mathilda Cominos, Matthew Fenton, Mohammed Osman, Natasha Mithal, Sharon Beesley, Sugeeta Sukumar, Udaiveer Panwar, Coral Greenstreet, Hayley Blackgrove, Katy Taylor, Victoria Williamson, Natalie Catt, Arafat Mirza, Sam Gibson, Steve Dann, Andrew Gillian, Miguel Capo-Mir, Cindy Slater, Hasmath Marjolin, Nikki Crisp, Rachel Larkins, Sandra Holness, Sarah Lines, Susan Rogers, Claire White, Julie Buckley, Laura Kehoe, Lesley Rose, Louise Gladwell, Sarah Lightfoot, Tracy Boakes, Alba Tubau, Bonny Appleby, Jo Williams, Linda Wray, Louise Allen, Marian Wood, Adedolapo Sanni, Claire Pelham, Elizabeth Williamson, Hilary Zurakovsky, Jill Baker, Joanne Williams, Julie-Ann Davies, Karen Robinson, Kathleen (Kathy) Walsh, Kim Mears, Kim Travis, Margaret Lipsham, Paula Whichelo, Sharon Middleton, Sue Kelly, Susan Drakeley, Sydnie Loveland, Molua Young, Denise Crawford, Julie Griffiths, Julia McBride, Fiona Rowling, Cheng Lee Chaw, Maha Zarroug, Mohammed Kagzi, Clive Peedell, David Wilson, Devadasan Shakespeare, Hans Van der Voet, Jason Wong, John Hardman, Steven Pratt, Anne Hardwick, Emma Pringleton, Jo Atkinson, Joanne Atkinson, Kate Rees, Michaela Davenport, Michaela Devenport, Rebecca Richards, Andrew Vaux, Craig Mower, Luca Settimo, Piers Loxley Winder, Piers Winders, David Chadwick, Keith Harland, Paul Jones-King, Alison Barnes, Claire Elliott, Emanuela Mahmoud, Alison Chilvers, Carol Long, Helen Carver, Jane Thompson, Julie Potts, Lisa Peacock (nee Wayman), Paula Milne, Emma Thompson, Helen Dunn, Katherine Tyler, Lynne Naylor, Sarah Kiddell, Sarah McAuliffe, Agnieszka Skotnicka, Andrea Watson, Charlotte Jacobs(née Kitching), Rita Mohan, Vicky Hanlon, Judith Moore, Alex Mitchell, Elle Cameron, John Frew, Nicola Hannaway, Noor Harris, Robert Chandler, Shahid Iqbal, Ashraf Azzabi, Ian Pedley, Rhona McMenemin, Amanda Henderson, Catherine Marsh, Emma King, Gemma O'Neill, Georgia Ross, Hannah Downs, Janine Tate, Katie Bain, Lucy Blackwell, Marianne Smith, Victoria Thomas, Andrew Herridge, Craig Alderson, Edgar Paez, Gerard Oakes, Ian Campbell, Roger Carr, Thomas Jarvis, Ben Hood, Mark Johnson, Naeem Soomro, Peter Murphy, Dianne Turner, Elizabeth Reay, Kristine Hawkins, Ruth Latter, Sarah Osborne, Sarah Rowling, Sarah Wright, Nichola Waugh, Ann Hudson, Caroline Dobeson, Diane Conner, Diane Connor, Dianne Wake, Elaine Greaves, Hazel Forsyth, Hazel Masson, Irene Jobson, Jenny Smith, Julie Thohig, Laura Jameson, Lauren Boal, Lavanya Mariappan, Penny Bradley, Ruth Sinnott, Sue Farrell, Sunita Kholi, Sunita Kollu, Xue Jiang, Carole Stobbart, Kay Carson, Lesley Naik, Kudingila Madhava, Alison Brown, Cindy Whitbread, Tracey Tidbury, Mark Johnson, Rachel Gabitass, Neel Bhuva, Adam Mitchell, Charlotte Westbury, David Woolf, Hamoun Rozati, Hannah Tharmalingam, Janaka Cooray, Joanne Kosmin, Lai Cheng Yew, Mohammed Abdul-Latif, Russell Moule, Sara Kashani, Claire Zane, Dolan Basak, Henry Mandeville, Huiqi Yang, Jeanette Dickson, Jennifer Chard, Kasia Owczarczyk, Katie Wood, Kent Yip, Lai-Cheng Yew, Linda Swaney, M Williams, Mausam Singhera, Nicola Anyamene, Olivia Hatcher, Paolo De Jesu, Peter Ostler, Rachael Khong, Robert Hughes, Roberto Alonzi, Shaista Harpeer, Shiv Gayadeen, Sonia Li, Viwod Mullassery, Aamna Rashid, Freya Ball, Harmeet Sangha, Juhee Kong, Lucy Collins, Rose Bell, Tahmina Shakil, Alice Ramsden, David Tan, Farhan Ahmed, Sam Bosompem, Heidi Rana, Jessica Finch, Kari Evans, Nalini Shah, Rakhi Jain, Shakeda Lakha, Bhanthi Kanagaratnam, Hannah Phillips, Harsha Vara, Helen Cladd, Justina Kailey, Lesley Mitchell, Nazma Damani, Nicola Cutmore, Paulina Kowalewska, Sapna Kaur, Elaine Lousley, Hameeda Sultany, Jessica Milner, Sara Abbassi, Suzanne Jenkins, Peter Hoskin, Adam Fullagar, Charlotte Kamlow, Chin Chong, Ewan Shawcroft, Junhao Lim, Lauren Jones, Maeve Pomeroy, Melanie Boafo-Yirenkyi, Rebekah Webb, Rohan Tharaka, Rohan Tharakan, Sadia Abdullah, Sarah Taylor, Shiv Uppal, Thomas Moore, Wai Hou Sam, Ananth Sivanandan, Charlotte Ellis, Daniel Saunders, Eliot Chadwick, Georgina Walker, Ian Sayers, Jamie Mills, Louise Brookes, Santhanam Sundar, Adele Malson, Asmaa Sa Omer, Camille Hutchinson, Hannah Thurlow, Jade Eggleton, Kayleigh Mills, Lucy Howard, Leanne Alder, Alex Blades, Jacob Szolin-Jones, Daniel Kumar, Matthew Brazkiewicz, Owen Cole, Tin Sang-Tsang, Anita Stevenson, Katie Carter, Phillipa Sum, Samantha Chetiyawardana, Tania Slater, Carol Gooch, Kathryn Moore, Susan Elliott, Cody Jevons, Rachael Chivers, Sarah Widdowson, Stephanie McGonagle, Caitlin Todd, Rena Chauhan, Stacey Green, Andrew White, Ellanna Guithi, Michael Tilby, Andrew Chan, Yakhub Khan, Damilola Jayeoba, Holly Lawrence, Kerry Flahive, sara Taylor, Arandeep Hayer, Albert Mislang, Jacob Bourne, Andrea Mills, Inderjit Atwal, Jenna Williams, Alison McCallum, Jessica Gunn, Karen Shorthose, Michaela Hill, Pritpal Klear, Rachael Oates, Rachel Fergusson, Sarah Fergusson, Winni Singh, Jeanette Knapp, Melanie Taylor, Sabiya Nasima, Judith Lake, Agata Rembielak, Anthea Cree, Ehab Ibrahim, Helen Joyce, Hwoeifen Soohoo, Kanal Gupta, Mohammad Abutarb, Parth Desai, Richard Walshaw, Shabaz Hussain, Shazril Imran Shaukat, Stephen Kennedy, Victoria Lavin, Ananya Choudhury, Anna Tran, Jacqueline Livsey, Peter Mbanu, Ruth Conroy, Shaveta Mehta, Dellesa Robinson, Sophie Hovenden, Mark Livingstone, Farhan Karim, Richard Jones, Terence Hinton, Sarah Warran, Udeme Ohia, Leena Mistry, Amy Slack, Anna Pracz, Dawn Johnstone, Joanne Allsop, Joanne Johnson, Joanne Reed, Kamala Ramatar, Kirstie Smith, Lyndsay Scarratt, Ruth Halford, Suzanne Bland, Wendy Cook, Hadia Ashraf, Jemma McLaughlin, Ami Sabharwal, Avinash Gupta, Katherine Hyde, Laura Robledo, Silke Hahnewald, Simon Wyatt, Tessa Greenhalgh, Thinn Pwint, Benjamin Fairfax, David J Cole, Elaine Sugden, Gerard Andrade, Mark Prentice, Meenali Chitnis, Paul Colin Miller, Philip Camilleri, Robert Stuart, Robert Watson, Elizabeth Hadley, Kelly Wigglesworth, Lauren Booker, Patrycja Jastrzebska, Sophia Shahzad, Swapna Thummala, Sywlia Bekulart, Daniel Ajzensztejn, Henry Chesson, Hugo De La Pena, Mark Tuthill, Naveen Sankighatta, Richard Cousins, Will Goodman, Matthew Mooney, Martha Woodward, Rachel Hart, Rosita Broderick, Ann Murphy, Charlotte Davies, Jo Wilson, Kerrie Marston, Julie Pinder, Katherine Jacob, Magdalena Benysek, Sandra Mukkath, Sarah Markus, Ana De Veciana, Anju Chalin, Evanthia Komninidou, Gabriela Kuzmycha, Gemma Austin (nee Glover), Hazel Wynn, Jane Boutflower, Sarah Lawrey, Trish Green, Usharani Devi Wahengbam, Andrew Protheroe, Tiago Rodrigues, Fiona Mellor, Joseph Davies, Yogesh Nishchal, Joe Davies, Maxine Flubacher, May Lwin, Perric Crellin, Sue Brock, Becky Troke, Felicity Clapp, Sarah Patch, Elizabeth Woodward, Nichola Downs, Craig Vincent, Neal Beamish, Roger Wheelwright, Deryck Burton, Lee Tbaily, Emma Wesley, Emma Williams, Helen Morling, Kate Mutendera, Kate Urquhart, Louise Heckford, Savina Elitova, Delia Whiteman, Elizabeth Clarke, Lyn Jackson, Sally Munden, Sharon Power, Sophie Rix, Stephanie Jones, Amanda Iskender, Hilary Blaney, Sally Gillespie, Sandy Pressdee, Sara Orford, Seonaid Wright, Susan Saxby, Teresa Coffin, Fionnuala Houghton, Judith Carser, Leanne McCourt, Akash Maniam, Akash Maniam, Alice White, Alisha Damani, Azarel Virgo, Caroline Chau, Charlotte Davies, Chloe Holden, Eleanor Jones, Harliana Mohd Yusof, Jack Broadfoot, Jeng Heng Ching, Joanna Hack, Joni Howells, Kudingila Madhava, Mark Noble, Matthew Moe, Megan Rowley, Mona Hassan, Nataliya Martynyuk, Oluwatobi Adeagbo, Shyamkia Acharige, Syed Shah, Umapathy Hombaiah, Vara Prasad Devara, Victoria True, Yvonne Mangan, Joanna Gale, Khalid Hameed, Mario Uccello, May Lwin, Mya Gyi, Sarah Ellis, Yoodhvir Nagar, Daniel Bloomfield, Dominic Hodgson, Robert Williams, Jennifer Hale, Jillian Andrews, Tracey Dobson, Tracy Callen, Wendy Golding, Wendy Stacey, Catherine Tolentino, Giuseppe Banna, Heather Cuell, Kathy Blight, Lisa Murray, Mila Roca, Anna Stephenson, Badrriyya Mohamedali, Catrin Watkinson, Lorna Meadows, Mary Wands, Claudia Langer, Miklos Pless, Natalie Fisher, Sabina Schacher, SusyAnn Shaw, Veronika Nagy, Beatrice Brinkers, Cindy Wanger, Martina Pfitzner, Nicole Kradolfer, Hubert John, Lynsey Dean, Christina Hague, Jose Rico, Martin Swinton, Natalie Charnley, Nicola Flaum, Omi Parikh, Sophie Raby, William Croxford, Yee Pei Song, Alison Birtle, Anna Macpherson, Catherine Thompson, Deborah Williamson, Duleer Majeed, Falalu Danwata, Marcus Wise, Norma Sidek, Shahzad Gul, Tanmay Mukhopadhyay, Win Soe, Claire Corless, Rebecca Wilby (nee Hall), Rose Ellard, Sarah Preston, Margaret Brunton, Andrew Martyniak, Davide Garau, Dominic Mounsey, Billy Hefferon, David Barber, Hemant Patel, Roy Shentall, Cassandra Gleeson, Deborah Weavers, Haiyan Huang, Mandy Armstrong, Nafisa Arden, Sharon Curran, Shelia Calvert, Andrea Ashton, Louise Hough, Catherine Walmsley, Christina Robinson, Deepsi Khatiwada, Hazel Preston, Amanda Alty, Caroline Hatch, Claire Hennigan, Helen Spickett, Helen Spickett, Katherine Ashton, Nina Vekaria, Patricia Knight, Stephanie Cornthwaite, Elizabeth Haydon, Emilia Bruton, Gagan Bhatnagar, Nicola Dallas, Osamah Alasadi, Phillip Webb, Phillipa Johnstone, Rowena Cazalet, Silke Hahnewald, Abdolnasser Aminiraouf, Ali Abbas, Georges Sinclair, Helen O'Donnell, Paul Rogers, Rebecca Johnson, Rebecca Varatharajah, Richard B Brown, Robert Jones, Sean O'Cathail, Shawn Ellis, Simon Wyatt, Stephen Parr, James Church, Steven Gulliver, Thomas Kindley, Geraldine Mason, Kate Preston, Nicole Gould, Wioletta Kowalczyk-Williams, Christina Lewis, Pooja Pabari, Royda Hadi, Andreia da Cruz, Anna Gillham, Claire Connolly, Emma Vowell, Jo Hand, Maxine Gauntlett, Omotola Ogunnigbo, Sanita Gurm, Allison Hunt, Catherine Deytrikh-Smith, Debbie Cartwright, Fiona Everson, Gabrielle Ball, Helen Purdon, Jane Atkinson, Juliette Dye, Kirsty Horwood, Kristy Coomber, Maryam Amole, Norma Shields, Sian James, Suzanne Foxwell, Tolu Okeke, Ayyaz Munawar, Bartlomeij Kurec, Menna Fonda, Mujtaba Syed-Khaja, Nge Nge Thida, Asha Sivapalasuntharam, James Best, Joanna Hamilton, Lisa Capaldi, Paul Flinders, Sabihya Wontumi, Thakshayini Shanthakumar, Jacob Taylor, Jonathan Davies, Alison Harrison, Amanda Holdsworth, Ann White, Jayna Thakrar, Veronica Rowlands, Hayley Hodson, Helen Tranter, Maggie Brown, Stephanie Cook, Jennifer Young, Jeanette Knapp, Eva Letalova, Alexander Pawsey, Danny Koroma Koroma, Kathryn Tarver, Maria Martinou, Jonathon Shamash, Amy Lewis, Ramachandran Subramaniam, Stephanie Gibbs, Thi Vu, Mohammed Rashid Khan, Revanth Jannapureddy, Samuel Mugari, Simerjyot Mudhar, Neale O'Brien, Neil Fisher, Yousaf Razzak, Parveen Dugh, Amani Chowdhury, Mariha Khalid, Ana-Marie Pena-Remorin, Dalisay Domingo, Helen Mackenzie, Tina Mills-Baldock, Isabel Syndikus, Shaun Tolan, Duncan Knowles, Ian Allen, Andrea Young, Rebecca Madew (nee Tinker), Nemonie Marriott, Nicholas Boxall, Anna Tran, Richard Cowan, Danielle Platt, Elina Jose, Joanne Henry, Kay Goulden, Euan Green, Maurice Lau, Oliver Wadsworth, Tony Elliott, Chris Betts, David Shackley, Jason Howard, Kieran O'Flynn, Mark Stapleton, Richard Jones, Christine Farnworth, Claire Duncan (nee Keatley), Claire Keatley, Kathryn Cawley, Siny George, Cellins Vinod, Claire Dickson, Helen Farrell, Samia Hanif, Soney Dharmaprasad, Angela Ashton, Anne-Marie Peers, Ashley Harris, Catherine Redshaw, Jean Jellicoe, Kathryn Fry, Leah Harter, Rachael Allen, Vicky Thomas, Noel Clarke, Jill Youd, Melanie Taylor, Sarah Kirk, Ian Renwick, Khaliq Rehman, Laith Alsaket, Mohan Hingorani, Nabil El-Mahdawi, Mohammad Muneeb Khan, Richard Khafagy, Russell Morgan, Abigail Rowbotham, Caroline Savage, Diana Ionita, Fizzah Asif, Lydia Kerr, Poppy Cottrell-Howe, Courtney Cole, Donna Anderson, Rachel Spooner, Callum Childs, Dominic Burns, Andrew Robertson, Arran Fletcher, Jordan Toohie, Kevin Brame, Paul Wood, Simon Hawkyard, Jacqui Smith, Lisa Armitage, Samantha Stead, Tania Neale, Tanya Hartley, Alison Ames, Alison Turnbull, Anne Nunn, Joanne Fletcher, Rachel Harrison, Sacha Honour, Adnan Kabir, Alicia Rodgers, Janine Mallinson, Laura Barman, Pippa Carlton-Rylance, Polly Needs, Amie Stewart, Carol Popplestone, Cheryl Donne, Chloe Box, Jane Taylor, Sarah Kent, Tracey Hawkes, Vic Gacek, Lucy Walkington, Mymoona Alzouebi, Prashanth Sanganalmath, Roseleen Sheehan, Shabbir Rawther, Tathagata Das, Virgil Sivoglo, Carmel Pezaro, Shiyam Kumar, Catherine Ferguson, James Lester, Janet Brown, Katie Bowen, Linda Evans, Louise Murray, Omar Din, Peter Kirkbride, Chloe Clegg, Georgia Douglas, Jessica Medcalf, Rebecca Lomax-Allen, Steffy George, Alexandra Firth, Cyper Allan, Ryan Asher, Ryan Davies, John Martindale, Mark Holliday, Richard Brown, Roger Burkinshaw, Anne Smythe, Eileen Marsh, Gemma Dale, Janine Smedley (nee McCabe), Julia Disney, Kate Gibbins, Jess Aldred, Leigh Fiorentino, Lucy Birch, Ruta Segamogaite, Catherine Spalton, Elizabeth Hodgkinson, Joanne Bird, Katherine Williams, Lucy Smith, Lynne Ashmore, Marion Hutchinson, Rachel Toes, Sarah Brown, Susan Bishop, Kim Wood, Gemma Searle, Shazad Aslam, Abel Zachariah, Aitzaz Qaisar, Beshar Allos, Erica Beaumont, Huzeifa Abdel, Huzeifa Gadir, James Best, Lisa Capaldi, Lucy Pennant, Mathai Varghese, Narayanan Srihari, Qamar Ghafoor, Rajanee Bhana, Sundus Yahya, Alison Tilley, Anna Law, Danielle Childs, Gemma Lee, Jenny Simm, Lisa Evans, Nicola Henderson, Riquella Abbott, Suzanne Pope, Andy Taylor, Michael Leigh, Ravi Prashant, Craig Pickering, Sanal Jose, Emma Weaver, Mandy Beekes, Natasha Wallbank, Rachel McGregor, Gill Ferguson, Harpreet Singh, Hayley Hughes, Sandra Smith, Sunita Kurian-Downer, Indukala Chennattukungu, Jenny Lakin, Angela Yeomans, Catherine Santiago, Elena Michael, Karen Nicholas, Mandy Bates, Nicola Jones, Rebecca Wilcox, Renee Poulsom, Sally Potts, Siobhan Kilbane, Verity King, Catherine Orrell, Emma Neeves, Helen Moore, Marion Adams, Ashraf Azzabi, Sally Hall, Judith Mckenna, Amy Burns, Jessica De Sousa, Judith Moore, Sue Morrison, Maxine Turner, Caroline Chan, Caroline Chau, Chloe Holden, Chris Coyle, Emma Brown, Kim Teasdale, Matthew Wheater, Robert Kemp, Simon Crabb, Tessa Greenhalgh, Catherine Heath, Graham Mead, Harish Reddy, Victoria McFarlane, Ivanila Atauasova, Anna Sieradzka, Anna Stephenson, Nithya Raj, Rajitha Kamalakshan, Rebecca Rice, Adele Ruiz, Julie Kennedy, Susan Morton, Aneta Zahorska, Annelise Haskell, Archana Gadve, Caroline Andrews, Carolyn Mitchell, Deborah Scott, Holly Burton, Leanne Reader, Liane Armstrong, Lucy Galloway, Maureen McAuley, Nikki Carney, Nikki Prewitt, Oyeleye Oyebola, Sarah Oliver, Sau-Mon Tsang, Yanli Li, Carina Mundy, Donna Kimber, Fabiola Morales-Azofra, Julie Gwilt, Kirsty Cumming, Lorraine Street, Lucy Elswood, Shauna Wakefield, Manal Alameddine, Neeraj Bhalla, Asha Sivapalasuntharam, Chinnamani Eswar, Margaret Brunton, Ken Gardner, Laurie Lomax, Ann Wearing, Dawn Barker, Marie McBride, Sandra Robinson, Anna Morris, Heidi Moran, Teresa Monahan, Angela Scullion, Lisa Dobson (nee Child), Linda Schinkel, Aurelius Omlin, Christoph Schwab, Dominik Abt, Christian Rothermundt, Daniel Engeler, Mannel Jungi, Silke Gillessen, Stefan Prensser, Sigrid Patel, Eloise Kremer, Karin Zuern, Karin Zurn, Claudia Hormann, Sibylle Schapper, Aspasia Soultati, Fiona McKinna, Kathryn Lees, Sharon Beesley, Claire Rutherford, Sarah Draper, Mark Whitfield, Steve Garnett, Gail Pottinger, Jo-Anne Taylor, Kay Jones-Skipper, Atikah Ayaz, Lauren McCrisken, Sarah Goodwin, Theresa Baumber, Joanna Howard, Claudia Hormann, Sibylle Schapper, Roger Plail, Anna Anosova, David Woolf, Mawuelikem Assoku, Nikhil Oommen, Alkhaldi Ashraf, David Ward, Jonathan Towler, Leena Mukherjee, Robert Hughes, Steven Watkins, Natalie Rahim, Sayyida Nembhard, Martin Ebon, Stephen Almond, Clare Collins, Jemma Gilmore, Sunita Gohil, Sura Dabbagh, Alice Valle, Corinne Bradshaw, Elen Witness, Rhos Gabriel, Anita Rana, Katie Poole, Roisin Schimmel, Vicky Hills, Carmel Anandadas, Satish Venkateshan, Umi Hatimy, Apurna Jegannathen, Catherine Coyle, John Logue, Abigail Mackley, Anna Kellingray, Oluwademilade Odewumi, Sarah Smallwood, Aelens Brauckman, Benjamin Ralphs, Donald van Welsenes, John Kilmartin, Jonathan Wong, Paul Berry, Wasim Akhtar, Adebanji Adeyoju, Andrew Sinclair, David Ross, Gerald Collins, Patrick O'Reilly, Richard Brough, Stephen Bromage, Stephen Brown, Helen Haydock, Louise Brown, Susan Hopkins, Abigail Pemberton, Alissa Kent, Emma Goodwin, Emma Taylor, Julie Melville, Katrina Wade, Lucy Orrell, Magda Kujawa, Miriam Avery, Mkyla Reilly, Susan Graham, Zoe Jordan, Catherine Fox, Christina Gilmour, Eleanor Anscombe, Emma Hewitt, Jean Cheetham, Jill Taylor, Nicola Hermitage, Pat Clitheroe, Sam Corcoran, Sarah Connolly nee McKenna, Sheila Hodgkinson, Tracie Cocks, Devadasan Shakespeare, Abdul Mian, Darren Leaning, Jenny Smith, Devadasan Shakespeare, Gaurav Kumar, Gala Stancev Stevanovic, Helen Wardle (nee Wilson), Moira Percival, Andrew Sigsworth, Bill Wetherill, Victor Palit, Hyder Latif, Helen Dunn (nee Carey), Jeanette Naisbitt, Pam Race, Sarah Pitcairn, Alison Chilvers, Leigh Pollard, Emma Jameson, Lynda Poole, Sumera Butt, Fawzi Adab, Rajanee Bhana, Salil Vengalil, Elizabeth Sellars, Emma Jackson, Christopher Luscombe, Robert Green, Liberty Verueco, Sharon Rollison, Alison Tute, Angela Peake, Angela Ward, Marion Evans, Eden Ball, Alison Myatt, Elizabeth Williamson, Grace Gough, Isabel Breeze, Julie Storer, Katrina Parkinson, Rowena Smith, Rachel Pearson, Shahid Iqbal, Ashraf Azzabi, Ian Pedley, Kathryn Wright, Stephen Laybourne, Rod Beard, Stephen Butler, Amanda Howey, Fiona Wakinshaw, Jane Cole, Paula Newton, Terri Haldane, Christine Harle, Fiona Wakinshaw, Julia Scott, Karen Shield, Michelle Edwards, Vivienne Hullock, Adham Hijab, Alex Tan, Angela Pathmanathan, Gerard McVey, Nora Sundahl, Susan Lalondrelle, Alison Tree, Chris Parker, Ray Shepherd, Robert Huddart, Rosalind Eeles, Vincent Khoo, Lucy Featherstone, Victoria Sjolin, Martha Bullimore, Alexander Macnab, Amir El Ghazal, Douglas Brand, Nick Hunnings, Tiaan Jacobs, Ruth Woode-Amissah, Zaynah Gurreebun, Sally Moore, Annette Musallam, Claire Crowley, Helen Stidwell, Janine Flohr, Jenni Parmar, Kelly Jones, Kirsty Cuthbertson, Laura Hennelly, Rookmeen Alighan, Bernadette Johnson, Chloe McCormack, Fatima Ahmed, Sue Cromarty, Alan Horwich, David Dearnaley, Mark O'Beirn, Daniel Ford, Lorna Swaddle, Steve Hay, Chen Bartlett, James Whitehouse, Helen Thomas, Ellen Drew, Ann Schumacher, Arlene Oldan, Beena Mistry, Helen Taylor, Janet Prentice, Kamaldeep Ajimal, Rachael O'Beney, Sarah Rogers, Shobit Baijal, Sundip Sohanpal, Alison Maidment, Katy Moore, Lubna Khan, Andrew Brocklehurst, Elena Macleod, Fiona Smith, James Price, Jun Lim, Lauren Jones, Michael Ocathail, Muhammad Gill, Robert Goldspring, Sadia Abdullah, Sarah Taylor, Wai Hou Sam, Benjamin Masters, Daniel Saunders, Eliot Chadwick, Georgina Walker, Louise Brookes, Andrea Palfreman, Jamie-Rae Burgoyne, Lisa Rahn, Victoria Moore, Shila Hamzepur, Terri-Ann Sewell, Wayne Lovegrove, Dominic Nash, Steve Haigh, Inez Wynter, Katie Slack, Sarah Shelton, Margaret Wheatley, Samantha Boam, Samantha March, Linda Otter, Lynne Wade, Rebecca Holmes, Susan Smith, Ahmed Shaheen, Aijaz Lone, David Brown, Delia Pudney, Fiona Williams, Helen Fitzgerald, N Sindgi, Nia Jackson, Rhian Davies, Ricky Fraser, Russell Banner, Sarah Gwynne, Satish Kumar, Sharath Gangadhara, Sheena Lam, Wael Mohamed, Gianfilippo Bertelli, Jason Lester, Mau-Don Phan, Nicola Davies, Angharad Phillips, Anne Thomas, Bethan Williams, Ellen Tait, Karen Chesters, Katie Tanner, Naomi Woods, Nicola Lemon, Alex Richards, Carl Ackland, James Morgan, Lewis Jones, Mark Rogers, Stuart Evans, Ashok Kumar, Brian Phillips, Euan Pratt, Amanda Cook, Charlotte Young, Dawn Withers, Gillian Palmer, Gillian Willetts, Helen Cheley, Lesley Richards, Lynne Breeze-Jones, Alex Franklin, Gillian Jones, Karen Phillips, Mair Roberts, Amy Quinton, Chelsea Jenkins, Elizabeth Evans, Emily Harris (n. Marchant), Emma Dangerfield, Judith Gooding, Maria Johnstone, Michelle Romano, Renata Poole, Alison Stretch, Amanda Jackson, Donna Lear, Gail Povey, Jayne Caparros, Leanne Quinn, Lisa Ellis, Lorraine Gammon, Nia Viney, Susie Pitcher, Tracey Ford, John Wagstaff, Dorota Marciniak, Raj Jampana, Aruna Medisetti, David J Cole, Dorothe Maramak, Esme Hill, Gerard Andrade, Omar Khan, Shiroma De Silva-Minor, Victoria Gibson, Emma Wakefield, Graham Brown, Joseph Stevens, Ronak Patel, Tim Owen, Christopher Clarke, David Newell, Jonathan Lewis, Mike Lewis, Vivian Zinyemba, Chanelle Meyer, Karen Smith, Rebecca Belcher, Sarah Cotton, Sue Meakin, Amanda Colston, Caroline Pensotti, Debbie Palmer, Jean Kordula, Laura McCafferty, Lesley Haxton, Sarah Grayland, Sarah Long, Catherine Lewis Clarke, Cerila Parajes, Deborah Scott, Donna Lake, Fahad Fazal, Rachel Messenger, Suzannah Pegler, Aiste Baltramaityte, Ania Jones, Ellen Starling, Ellie Hewitt, Nicola Cowling, Sally-Ann Parkin (nee) Lee, Tracey Sargent, Helen Winter, Jan Dodge, Tracey Sargent, Clair Brunner, Elena Macleod, Hannah Berry, Joanne Botten, Manivannan Periasamy, Mohini Varughese, Nicola Cox, Olivia Fraser, Darren Brady, Emma Gray, George Plataniotis, Gihan Ratnayake, John Graham, Joseph Jelski, Manjusha Keni, Mary Tighe, Rebecca Denslow, Robert Zorica, Abby Farzaneh, Amy Sawyer, Christina Branfield, Corinne Pawley, Hayley Cornall, Jasmine Youens, Odunayo Kalejaiye, Rachel Coe, Rebecca Brown, Rebecca Twemlow, Guillermo Reina-Ruiz, John Allinson-Smith, Joshua Woollven, Lee Talbot, Luke Stephens, Tamlyn Russell, Ian Bodger, Jarrod Dunn, Jarrod Dunn, Richard Burgess, Ruaraidh MacDonagh, Ruaraidh MacDonagh, Simon Goldsworthy, Alison Snell, Amanda Groves, Ceri Poyntz-wright, Clair Hinton, Claire Sowerby, Fiona Goodchild, Francesca Allen, Joanne Rogers, Joanne Taylor, Lynn Leat, Sue Mahoney, Susan Crouch, Michelle Farrar, Alison Whitcher, Anna Masamba, Catherine Lane, Christine Webster, Fen Lewen, Joan Kemp, Karen Tanner, Martha Wrigley, Moira Tait, Nicola Cutmore, Rebecca Purnell, Samantha Northover, Sara Green, Sara Myers, Alison Chedham, Angela Locke, Jan Ashcroft, Jan Ashcroft, Joy Rowe, Judith Mathie, Judith Mathie, Lisa Bowern, Lucy Howell-Drewett, Nita Beacham, Rebecca Tucker, Rebecca Tucker, Rebecca Wallbutton, Anna Llado, Enrico Roggero, Barbara Marongiu, Michele Moro, Sabine Van Den Bosch, Jane Thomson, Helen Saxby, Victoria Bell, Victoria Cope, Anna Lydon, Beverley Watkins, Erica Watts, Fiona Roberts, Jorg Michels, Rajaguru Srinivasan, Emily Flavell, Helen Kimber, Kirsty Jones, Kirsty Pearce, Sally Wells, Sophie Gittus, Stacey Davies, Linda Welsh, Kenneth Almedilla, Lee Merry, Peter Fletcher, Peter Pugh, Seamus McDermott, Andrew Harford-Brown, Magdi Kirollos, Mark Brennan, Martyn Blundell, Robert Mason, Angela Foulds, Kirsty Lester, Lauren Blunt, Michele Allison, Shelley Chamberlain, Tyler Lowe, Christine Rawlings, Donna Cuffe, Elaine Vandecandalaere, Amy Millington, Catherine Brookman, Catherine Marshall, Classy Lam, Emmie Arbury, Fleur Rogers, Janet Palmer, Petra Gee, Sally Maddison, Sarah Rees, Sophie Norman, Sue Forbes, Amanda Vian, Helen Greedus, Ingrid Koehler, Jo Blurton, Lorraine Thornton, Louise Paatz, Lyn Micklewright, Melody Cross, Sarah Wright, Victoria Bell, Laurent Antoni, Joaquin Casariego garcia luben, Ilde Herrygars, Florence Lefresne, Rod Murphy, Mohamed Samir, Hind Stitou, Paul Cadle, Christine Geffriaud-Ricouard, Zsuzsanna Devecseri, Pam Brambles, John Galfin, Karla Martins, Gunther Boysen, and Padraig Moran
Supplementary Material
References
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Supplementary Materials
Data Availability Statement
Individual participant data can be requested via the general enquiries email: mrcctu.ctuenquiries@ucl.ac.uk, as per the moderated access approach of the Medical Research Council Clinical Trials Unit at University College London. Upon approval, individual participant data that underlie the results reported in this Article, after de-identification (text, tables, figures, and appendices), will be provided with a data dictionary, protocol, and case record forms relevant to the data.