Table 3.

SNPs within the consensus NF-κB sites on chromosome 22 that strongly affect binding affinity

	Position	Wild-type site	Variant site	p50p50		p50p65
				Wild	Variant	Wild	Variant
G/C	11377920	GGGAAGCTCC	GGGAACCTCC	0.523	0.309	0.531	0.277
T/C	19233627	GGGATCTTCC	GGGATCCTCC	0.418	0.156	0.383	0.086
A/G	22583878	GGAACACTCC	GGGACACTCC	0.215	0.348	0.176	0.422
T/G	23290863	GGAGTTTTCC	GGAGGTTTCC	0.445	0.106	0.391	0.078
C/T	27669037	GGAACTCCCC	GGAACTCTCC	0.719	0.109	0.871	0.215
G/A	28028256	GGGACATTCC	GGAACATTCC	0.508	0.063	0.727	0.102
C/T	28583158	GGGATGCTCC	GGGATGTTCC	0.336	0.453	0.262	0.520
T/C	30437898	GGAGCTCCCC	GGAGCCCCCC	0.598	0.395	0.527	0.238
G/A	34313170	GGGGCCTCCC	GGAGCCTCCC	0.754	0.262	0.625	0.231

The predicted rank for either NF-κB dimer changed by more than 0.25 by the SNP.