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. 2025 Jul 15;16:1611267. doi: 10.3389/fphys.2025.1611267

TABLE 1.

Algorithm for knee ACL tear mask region extraction with ROI.

Step Procedure
1 Selection and Loading
1.1 Extract PD-weighted DICOM images (initial resolution: 512 × 512 pixels)
1.2 Select ACL tear-related slices by expert radiologists
2 Conversion and Initialization
2.1 Convert DICOM to NII format using Python (maintains 512 × 512 resolution)
2.2 Generate initial black masks in NII format (background value: 0)
3 Annotation with ITK-SNAP
3.1 Load images and masks into ITK-SNAP
3.2 Annotate ACL tear regions as white by experts (tear regions: value 1)
3.3 Save final masks at 512 × 512 resolution
4 Preprocessing and Augmentation
4.1 Resize images and masks to 256 × 256 pixels (bilinear interpolation)
4.2 Apply random transformations and ACL tear-specific simulations (flipping, rotation ±1°, brightness ±0.01, contrast ±0.1, tear simulations)