Figure 2.
Competition ELISAs with representative Fab fragments. (A) M26Biotin is displaced from rMOG by itself (○), M38 (◊), and M45 (×) but not by M3-8 (□), M3-24 (▵), or M3-31 (▿). (B) M3-24Biotin is displaced only by itself (▵). (C) M3-31Biotin is displaced by itself (▿), M38 (◊), and M45 (×), and also by high concentrations of M26 (○). Highlighted in red are the Fab fragments that tightly cluster within the major immunogenic region of MOG. IGHV and IGKV gene usage is indicated in the legend.