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. 2025 Jul 26;17(7):109787. doi: 10.4330/wjc.v17.i7.109787

Table 1.

Epidemiological characteristics of acute myocardial infarction complicated by ventricular septal rupture before and after the implementation of emergency percutaneous coronary intervention, n (%)

Research object
Research center/country
Type of study population
AMI cases (n)
VSR incidence
Gender (male:female)
Implementation status of acute PCI
Year
Ref.
GUSTO Trial International multicenter (Europe and United States) AMI patients primarily receiving thrombolytic therapy 36303 798 (2.2) 1:1.2 Thrombolysis as the primary approach 1993 [84]
PAMI-1 and PAMI-2 Multicenter (America) AMI patients 1295 4 (0.31) - PCI 1995 [85-87]
SHOCK Research International multicenter (Europe and United States) Patients with cardiogenic shock complicated by VSR after MI 939 55 (5.86) - Thrombolysis combined with IABP, partial PCI 1999-2006 [88]
MOODY Registered Study China (multicenter) AMI 9265 52 (0.56) 0.625:1 Thrombolysis combined with IABP, partial PCI 1999-2016 [89]
- International multicenter STEMI, NSTEMI 9126362 10344 (0.11) 0.71:1 Thrombolysis combined with IABP, partial PCI 2003-2015 [9]
Huazhong Fuwai Cardiovascular Hospital China (single centre) VSR with percutaneous closure - 81 0.72:1 PCI and Percutaneous Septal Closure 2013-2020 [90]
Huazhong Fuwai Cardiovascular Hospital China (single centre) PIVSR patients - 213 0.95:1 PCI 2018-2023 [91]
CAUTION study(NCT03848429) International multicenter Post-infarction MCs - 720 1.46:1 Thrombolysis combined with IABP, partial PCI 2001-2019 [92]
Narayana Institute of Cardiac Sciences, India India (single centre) Patients diagnosed with post-AMI VSR and who underwent surgical closure of VSR by double patch technique - 77 2.67:1 Thrombolysis combined with IABP, partial PCI 2002-2022 [93]
Karachi Tabba Heart Institute, Department of Clinical Research in Cardiology Pakistan (multicenter) AMI-VSR 11428 67 (0.6) 1.68:1 PCI 2011-2020 [94]
First Affiliated Hospital of Xi'an Jiaotong University China (single centre) AMI-VSR 5395 42 (0.78) - PCI 2016-2020 [95]
Beijing Anzhen Hospital, Capital Medical University China (single centre) AMI-VSR - 180 0.94:1 PCI 2016-2023 [25]
Coronary Heart Disease Center, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College China (single centre) AMI-VSR 12354 70 (0.57) 0.89:1 Thrombolysis combined with IABP, partial PCI 2002-2010 [96]
Peking University People's Hospital Research China (single centre) STEMI 2057 16 (0.7) 1:1 11 cases of coronary angiography 1990-2004 [97]
- China (multicenter) AMI-VSR - 127 1.12:1 61.4% drug therapy, 24.4% TCC, 14.2% surgical intervention 2012-2019 [98]
Shenyang Northern Theater General Hospital China (single centre) AMI-VSR - 45 1.25:1 Surgery, IABP/ECMO 2012-2021 [99]
Cairo University Egypt (single centre) PIVSR - 32 1:1 PCI 2015-2023 [100]
Nanjing First Hospital Affiliated with Nanjing Medical University China (single centre) AMI-VSR - 50 0.63:1 PCI 2012-2021 [101]
National University of Singapore research Singapore (single centre) Analysis of Pathological Characteristics of VSR in Asian Populations - 40 1.2:1 Histopathology combined with immunohistochemistry 2010-2020 [102]
A tertiary care center in South India South India (single centre) Patients undergoing TCC - 21 2.5:1 PCI + TCC 2000-2014 [103]
Cleveland clinic United States (single centre) AMI-VSR - 38 1.375:1 PCI + Ventricular septal repair 1976-2023 [104]

AMI-VSR: Acute myocardial infarction complicated by ventricular septal rupture; PCI: Percutaneous coronary intervention; IABP: Intra-aortic balloon pump; STEMI: ST - elevation myocardial infarction; NSTEMI: Non ST - elevation myocardial infarction; TCC: Transcatheter Closure; ECMO: Extraciroireal membrane oxygenation.