Table 2:
Univariable logistic regression model for overall graft loss, overall mortality and death-censored graft loss in the entire cohort and subgroups by donor type.
All |
Deceased |
Living |
|||||||
---|---|---|---|---|---|---|---|---|---|
Variables | OR | 95% CI |
P-value | OR | 95% CI |
P-value | OR | 95% CI |
P-value |
Overall graft loss | |||||||||
Age at PKT | 1.051 |
1.041–
1.061 |
<.0001 | 1.065 |
1.052–
1.078 |
<.0001 | 1.007 | 0.990– 1.024 |
.437 |
Sex | 0.967 | 0.751– 1.245 |
.792 | 0.850 | 0.631– 1.144 |
.283 | 1.075 | 0.656– 1.762 |
.773 |
BMI at PKT | 1.037 |
1.009–
1.066 |
.009 | 1.038 |
1.005–
1.071 |
.022 | 0.998 | 0.944– 1.056 |
.949 |
CKD baseline disease 2 | 1.282 | 0.754– 2.179 |
.358 | 1.319 | 0.676– 2.574 |
.418 | 1.322 | 0.547– 3.196 |
.535 |
CKD baseline disease 3 | 1.065 | 0.714– 1.590 |
.757 | 1.138 | 0.701– 1.847 |
.6 | 0.900 | 0.435– 1.860 |
.776 |
CKD baseline disease 4 | 3.042 |
1.844–
5.020 |
<.0001 | 2.398 |
1.297–
4.432 |
.005 | 4.375 |
1.837–
10.422 |
.0009 |
CKD baseline disease 5 | 3.155 |
2.008–
4.958 |
<.0001 | 3.217 |
1.907–
5.426 |
<.0001 | 1.690 | 0.589– 4.852 |
.323 |
CKD baseline disease 6 | 1.421 | 0.928– 2.177 |
.106 | 1.296 | 0.763– 2.203 |
.338 | 1.653 | 0.802– 3.406 |
.173 |
CKD baseline disease 7 | 1.988 |
1.307–
3.026 |
.001 | 2.232 |
1.368–
3.639 |
.001 | 0.902 | 0.343– 2.371 |
.834 |
Cardiovascular disease (ref 0) | 2.076 |
1.464–
2.943 |
<.0001 | 2.134 |
1.436–
3.173 |
.0002 | 0.740 | 0.326– 1.677 |
.471 |
Diabetes mellitus (ref 0) | 2.027 |
1.472–
2.792 |
<.0001 | 1.867 |
1.289–
2.704 |
.001 | 1.950 |
1.009–
3.768 |
.047 |
Time on waiting list | 1.008 |
1.001–
1.015 |
.02 | 1.004 | 0.995– 1.012 |
.394 | 1.008 | 0.989– 1.026 |
.409 |
Donor type (ref 0) | 0.434 | 0.330–0.572 | <.0001 | ||||||
Donor age | 1.053 | 1.043–1.063 | <.0001 | 1.051 | 1.040–1.062 | <.0001 | 1.030 | 1.007–1.053 | .009 |
Donor height | 0.258 | 0.098–0.681 | .006 | 0.084 | 0.023–0.300 | .001 | 0.796 | 0.115–5.526 | .817 |
Donor weight | 0.999 | 0.992–1.007 | .881 | 0.996 | 0.987–1.005 | .356 | 1.003 | 0.988–1.018 | .72 |
Donor BMI | 0.999 | 0.991–1.007 | .792 | 1.018 | 0.991–1.046 | .2 | 0.997 | 0.983–1.011 | .669 |
Donor COD 2 (ref 1) | 1.740 | 1.186–2.555 | .005 | ||||||
Donor COD 3 | 1.060 | 0.623–1.805 | .829 | ||||||
Donor COD 4 | 0.821 | 0.183–3.689 | .7964 | ||||||
Donor HT (ref 0) | 2.353 | 1.732–3.197 | <.0001 | ||||||
Donor DM (ref 0) | 1.272 | 0.768–2.107 | .3498 | ||||||
CIT | 1.036 | 1.020–1.052 | <.0001 | 0.997 | 0.972–1.022 | .798 | 1.320 | 1.119–1.557 | .001 |
cPRA | 0.997 | 0.993–1.002 | .231 | 0.997 | 0.991–1.002 | .208 | 0.997 | 0.987–1.007 | .525 |
MM A 1 (ref 0) | 1.013 | 0.712–1.443 | .942 | 0.869 | 0.554–1.364 | .542 | 0.985 | 0.546–1.778 | .959 |
MM A 2 | 1.272 | 0.877–1.844 | .205 | 0.994 | 0.625–1.579 | .979 | 1.146 | 0.579–2.269 | .696 |
MM B 1 (ref 0) | 1.158 | 0.750–1.789 | .508 | 0.855 | 0.495–1.478 | .575 | 1.535 | 0.729–3.233 | .259 |
MM B 2 | 1.505 | 0.981–2.309 | .061 | 1.060 | 0.624–1.800 | .831 | 1.520 | 0.695–3.326 | .295 |
MM DR 1 (ref 0) | 0.867 | 0.647–1.160 | .334 | 1.068 | 0.762–1.498 | .702 | 0.731 | 0.402–1.329 | .304 |
MM DR 2 | 1.841 | 1.330–2.547 | .0002 | 2.513 | 1.703–3.708 | <.0001 | 1.470 | 0.777–2.782 | .236 |
Age difference | 0.990 | 0.980–1.000 | .045 | 0.976 | 0.961–0.991 | .003 | 0.990 | 0.974–1.006 | .203 |
UBI | 1.009 | 0.997–1.020 | .132 | 1.020 | 1.006–1.034 | .005 | 0.987 | 0.969–1.005 | .16 |
eGFR at PKT | 1.007 | 0.976–1.039 | .659 | 1.005 | 0.968–1.042 | .806 | 1.031 | 0.972–1.094 | .312 |
Overall mortality | |||||||||
Age at PKT | 1.110 | 1.091 | 1.128 | <0.0001 | 1.097 | 1.077 | 1.117 | <0.0001 | 1.125 |
Sex | 0.793 | 0.565–1.113 | .18 | 0.778 | 0.537–1.128 | .186 | 0.438 | 0.165–1.164 | .098 |
BMI at PKT | 1.054 | 1.018–1.091 | .003 | 1.031 | 0.991–1.072 | .129 | 1.092 | 1.004–1.188 | .039 |
CKD baseline disease 2 | 0.727 | 0.311–1.697 | .461 | 1.033 | 0.425–2.509 | .943 | <0.001 | <0.001–>999.999 | .967 |
CKD baseline disease 3 | 0.870 | 0.499–1.518 | .624 | 0.878 | 0.466–1.654 | .686 | 0.801 | 0.241–2.658 | .717 |
CKD baseline disease 4 | 4.444 | 2.468–8.002 | <.0001 | 3.070 | 1.523–6.188 | .002 | 9.185 | 3.013–28.003 | <.0001 |
CKD baseline disease 5 | 3.380 | 1.915–5.965 | <.0001 | 3.099 | 1.655–5.803 | .0004 | 1.759 | 0.344–8.981 | .497 |
CKD baseline disease 6 | 1.255 | 0.704–2.240 | .441 | 1.208 | 0.621–2.350 | .578 | 1.333 | 0.400–4.443 | .639 |
CKD baseline disease 7 | 2.221 | 1.299–3.796 | .004 | 2.277 | 1.259–4.120 | .007 | 0.803 | 0.159–4.042 | .789 |
Cardiovascular disease (ref 0) | 3.003 | 2.005–4.497 | <.0001 | 2.850 | 1.827–4.446 | <.0001 | 2.232 | 0.752–6.624 | .148 |
Diabetes mellitus (ref 0) | 2.479 | 1.680–3.657 | <.0001 | 1.939 | 1.247–3.013 | .003 | 4.172 | 1.782–9.766 | .001 |
Time on waiting list | 1.000 | 0.990–1.011 | .959 | 0.993 | 0.982–1.005 | .26 | 0.995 | 0.959–1.032 | .776 |
Donor type (ref 0) | 0.267 | 0.176–0.405 | <.0001 | ||||||
Donor age | 1.078 | 1.064–1.092 | <.0001 | 1.066 | 1.051–1.081 | <.0001 | 1.076 | 1.034–1.119 | .0003 |
Donor height | 0.267 | 0.080–0.893 | .03 | 0.142 | 0.032–0.631 | .01 | 0.248 | 0.024–2.533 | .239 |
Donor weight | 0.997 | 0.987–1.007 | .599 | 0.995 | 0.985–1.006 | .389 | 0.991 | 0.964–1.019 | .511 |
Donor BMI | 0.998 | 0.986–1.010 | .758 | 1.010 | 0.976–1.044 | .573 | 0.995 | 0.966–1.026 | .763 |
Donor COD 2 (ref 1) | 1.677 | 1.044–2.695 | .03 | ||||||
Donor COD 3 | 1.057 | 0.547–2.044 | .868 | ||||||
Donor COD 4 | <0.001 | <0.001–>999.999 | .986 | ||||||
Donor HT (ref 0) | 2.155 | 1.480–3.137 | <.0001 | ||||||
Donor DM (ref 0) | 1.034 | 0.537–1.991 | .919 | ||||||
CIT | 1.050 | 1.030–1.070 | <.0001 | 0.994 | 0.964–1.026 | .722 | 1.343 | 1.043–1.729 | .02 |
cPRA | 0.995 | 0.988–1.001 | .109 | 0.994 | 0.987–1.001 | .07 | 0.997 | 0.982–1.013 | .728 |
MM A 1 (ref 0) | 1.574 | 0.935–2.652 | .09 | 1.100 | 0.622–1.947 | .743 | 3.206 | 0.727–14.138 | .129 |
MM A 2 | 1.823 | 1.058–3.141 | .03 | 0.997 | 0.549–1.809 | .991 | 5.820 | 1.275–26.575 | .02 |
MM B 1 (ref 0) | 1.505 | 0.781–2.901 | .222 | 1.110 | 0.528–2.334 | .784 | 2.327 | 0.523–10.348 | .267 |
MM B 2 | 2.352 | 1.239–4.464 | .009 | 1.482 | 0.721–3.045 | .284 | 3.148 | 0.696–14.234 | .1236 |
MM DR 1 (ref 0) | 0.899 | 0.609–1.328 | .593 | 1.091 | 0.716–1.662 | .687 | 1.124 | 0.354–3.570 | .843 |
MM DR 2 | 2.018 | 1.329–3.065 | .001 | 2.414 | 1.507–3.869 | .0002 | 3.461 | 1.110–10.792 | .03 |
Age difference | 1.010 | 0.996–1.024 | .156 | 0.985 | 0.966–1.004 | .119 | 1.050 | 1.019–1.081 | .001 |
UBI | 1.017 | 1.001–1.033 | .03 | 1.020 | 1.003–1.037 | .02 | 1.013 | 0.976–1.051 | .495 |
eGFR at PKT | 1.016 | 0.976–1.058 | .447 | 1.026 | 0.982–1.073 | .249 | 1.004 | 0.911–1.106 | .939 |
DCGL | |||||||||
Age at PKT | 1.001 | 0.989–1.013 | .861 | 1.020 | 1.004–1.036 | .01 | 0.961 | 0.941–0.981 | .0002 |
Sex | 1.219 | 0.855–1.738 | .275 | 1.000 | 0.640–1.562 | .999 | 1.641 | 0.913–2.951 | .098 |
BMI at PKT | 1.010 | 0.971–1.051 | .613 | 1.040 | 0.992–1.090 | .104 | 0.939 | 0.872–1.011 | .094 |
CKD baseline disease 2 | 1.924 | 0.983–3.768 | .056 | 1.716 | 0.665–4.431 | .265 | 2.169 | 0.830–5.668 | .114 |
CKD baseline disease 3 | 1.290 | 0.742–2.241 | .366 | 1.536 | 0.755–3.124 | .236 | 0.964 | 0.394–2.358 | .947 |
CKD baseline disease 4 | 1.123 | 0.448–2.818 | .804 | 1.088 | 0.346–3.427 | .885 | 1.162 | 0.246–5.491 | .849 |
CKD baseline disease 5 | 2.307 | 1.190–4.473 | .013 | 2.522 | 1.135–5.604 | .023 | 1.591 | 0.422–6.005 | .493 |
CKD baseline disease 6 | 1.557 | 0.860–2.819 | .144 | 1.380 | 0.617–3.088 | .433 | 1.801 | 0.747–4.344 | .19 |
CKD baseline disease 7 | 1.542 | 0.826–2.880 | .174 | 1.809 | 0.841–3.888 | .129 | 0.966 | 0.296–3.153 | .955 |
CVD (ref 0) | 0.963 | 0.523–1.772 | .903 | 0.966 | 0.473–1.970 | .924 | 0.859 | 0.260–2.836 | .803 |
Diabetes mellitus (ref 0) | 1.333 | 0.814–2.185 | .254 | 1.497 | 0.846–2.646 | .166 | 0.878 | 0.308–2.504 | .808 |
Time on waiting list | 1.014 | 1.005–1.023 | .002 | 1.014 | 1.003–1.024 | .008 | 1.013 | 0.992–1.034 | .216 |
Donor type (ref 0) | 0.767 | 0.533–1.104 | .153 | ||||||
Donor age | 1.021 | 1.009–1.033 | .0004 | 1.023 | 1.010–1.037 | .0006 | 1.005 | 0.979–1.032 | .695 |
Donor height | 0.330 | 0.086–1.266 | .106 | 0.089 | 0.016–0.497 | .006 | 2.492 | 0.144–43.184 | .53 |
Donor weight | 1.002 | 0.991–1.013 | .719 | 0.998 | 0.985–1.011 | .734 | 1.008 | 0.991–1.026 | .342 |
Donor BMI | 1.000 | 0.990–1.010 | .97 | 1.026 | 0.986–1.068 | .211 | 0.998 | 0.982–1.014 | .769 |
Donor COD 2 (ref 1) | 1.639 | 0.909–2.956 | .1 | ||||||
Donor COD 3 | 1.055 | 0.464–2.398 | .898 | ||||||
Donor COD 4 | 2.322 | 0.491–10.985 | .288 | ||||||
Donor HT (ref 0) | 2.190 | 1.385–3.466 | .0008 | ||||||
Donor DM (ref 0) | 1.576 | 0.786–3.160 | .2 | ||||||
CIT | 1.013 | 0.991–1.035 | .256 | 1.001 | 0.964–1.040 | .962 | 1.274 | 1.041–1.560 | .019 |
cPRA | 1.000 | 0.994–1.006 | .963 | 1.001 | 0.994–1.009 | .742 | 0.997 | 0.985–1.009 | .604 |
MM A 1 (ref 0) | 0.659 | 0.414–1.050 | .08 | 0.624 | 0.321–1.210 | .163 | 0.683 | 0.353–1.323 | .259 |
MM A 2 | 0.888 | 0.546–1.445 | .632 | 0.991 | 0.515–1.910 | .979 | 0.523 | 0.217–1.260 | .149 |
MM B 1 (ref 0) | 0.919 | 0.526–1.603 | .765 | 0.654 | 0.312–1.371 | .2609 | 1.277 | 0.545–2.992 | .573 |
MM B 2 | 0.909 | 0.520–1.590 | .738 | 0.689 | 0.336–1.414 | .3097 | 1.023 | 0.405–2.589 | .961 |
MM DR 1 (ref 0) | 0.846 | 0.561–1.277 | .427 | 1.024 | 0.612–1.712 | .929 | 0.625 | 0.314–1.246 | .182 |
MM DR 2 | 1.464 | 0.919–2.331 | .109 | 2.081 | 1.170–3.703 | .013 | 0.866 | 0.391–1.918 | .722 |
Age difference | 0.970 | 0.956–0.983 | <.0001 | 0.967 | 0.944–0.991 | .007 | 0.963 | 0.945–0.981 | <.0001 |
UBI | 0.998 | 0.984–1.013 | .843 | 1.016 | 0.995–1.037 | .139 | 0.977 | 0.958–0.997 | .002 |
eGFR at PKT | 0.995 | 0.951–1.041 | .842 | 0.969 | 0.915–1.027 | .295 | 1.045 | 0.972–1.122 | .232 |
Significant values in bold.
COD: cause of death; HT: hypertension; DM: diabetes mellitus; MM: mismatch.
CKD baseline disease: 1, ADPKD; 2, CAKUT; 3, diabetes mellitus; 4, hypertension/RVD; 5, glomerulonephritis; 6, ‘other primary renal disease’; 7, unknown or missing.