Table 3:
Multivariable logistic regression model for overall graft loss, overall mortality and death-censored graft loss in the entire cohort and subgroups by donor type.
| All (N = 2327) | Deceased (n = 1349) | Living (n = 978) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | Baseline disease | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | |||
| Overall graft loss | |||||||||||||
| Age (years) | 1.01 | 1.00– 1.03 |
0.106 | 1.05 | 1.02–1.08 | 0.001 | 0.99 | 0.97–1.02 | 0.585 | ||||
| Sex (ref. male) | 1 | 0.94 | 0.68– 1.29 |
0.705 | 1.02 | 0.69–1.50 | 0.937 | 0.81 | 0.45–1.47 | 0.496 | |||
| BMI at PKT | 1.00 | 0.96– 1.03 |
0.828 | 1.00 | 0.96–1.05 | 0.927 | 0.98 | 0.91–1.05 | 0.565 | ||||
| CKD baseline disease (ref 1) | 2 | 2.64 |
1.42–
4.93 |
0.002 | 3.61 | 1.59–8.16 | 0.002 | 1.72 | 0.61–4.79 | 0.304 | |||
| CKD baseline disease (ref 1) | 3 | 1.19 | 0.74– 1.91 |
0.484 | 1.22 | 0.67–2.20 | 0.515 | 1.00 | 0.43–2.33 | 0.998 | |||
| CKD baseline disease (ref 1) | 4 | 1.80 | 0.84– 3.86 |
0.130 | 1.19 | 0.48–2.98 | 0.707 | 4.53 | 0.90–22.80 | 0.067 | |||
| CKD baseline disease (ref 1) | 5 | 1.94 |
1.10–
3.39 |
0.021 | 1.85 | 0.96–3.57 | 0.067 | 1.28 | 0.33–5.04 | 0.723 | |||
| CKD baseline disease (ref 1) | 6 | 1.51 | 0.92–2.46 | 0.100 | 1.27 | 0.68–2.38 | 0.447 | 1.94 | 0.87–4.36 | 0.107 | |||
| CKD baseline disease (ref 1) | 7 | 1.76 | 1.06–2.92 | 0.030 | 1.82 | 0.99–3.33 | 0.054 | 1.29 | 0.43–3.88 | 0.651 | |||
| CVD (0, no) | 1 | 1.51 | 1.00–2.29 | 0.050 | 1.49 | 0.92–2.42 | 0.106 | 1.64 | 0.66–4.04 | 0.286 | |||
| DM (0, no) | 1 | 1.02 | 0.62–1.68 | 0.927 | 0.98 | 0.56–1.70 | 0.935 | 1.22 | 0.33–4.55 | 0.764 | |||
| Donor type (0, deceased; 1 living) | 1 | 0.71 | 0.42–1.22 | 0.214 | |||||||||
| Donor age (years) | 1.03 | 1.02–1.05 | 0.001 | 1.02 | 1.00–1.04 | 0.132 | 1.03 | 1.00–1.06 | 0.046 | ||||
| Donor BMI (years) | 1.00 | 0.99–1.01 | 0.717 | 1.01 | 0.97–1.04 | 0.648 | 1.00 | 0.98–1.02 | 0.704 | ||||
| CIT (hours) | 1.00 | 0.97–1.03 | 0.932 | 0.99 | 0.96–1.03 | 0.731 | 1.39 | 1.15–1.67 | 0.001 | ||||
| cPRA (%) | 1.00 | 0.99–1.01 | 0.886 | 1.00 | 0.99–1.01 | 0.584 | 1.00 | 0.99–1.01 | 0.696 | ||||
| MM DR (n; ref 0) | 1 | 1.02 | 0.71–1.45 | 0.917 | 1.05 | 0.69–1.60 | 0.824 | 0.85 | 0.42–1.71 | 0.649 | |||
| MM DR (n; ref 0) | 2 | 1.67 | 1.10–2.53 | 0.015 | 1.73 | 1.05–2.86 | 0.033 | 1.54 | 0.69–3.42 | 0.289 | |||
| UBI | 1.00 | 0.99–1.01 | 0.733 | 1.01 | 1.00–1.03 | 0.171 | 0.98 | 0.96–1.00 | 0.080 | ||||
| All | Deceased | Living | |||||||||||
| Variables | Baseline disease | OR | CI − 95% | CI + 95% | P-value | OR | CI − 95% | CI + 95% | P-value | OR | CI − 95% | CI + 95% | P-value |
| Overall mortality | |||||||||||||
| Age (years) | 1.10 | 1.07 | 1.13 | 0.001 | 1.10 | 1.06 | 1.14 | 0.001 | 1.13 | 1.05 | 1.21 | 0.001 | |
| Sex (male; ref) | 1 | 1.34 | 0.86 | 2.10 | 0.199 | 1.23 | 0.75 | 2.02 | 0.414 | 2.85 | 0.77 | 10.59 | 0.118 |
| BMI at PKT | 0.98 | 0.93 | 1.03 | 0.370 | 0.97 | 0.92 | 1.03 | 0.329 | 0.90 | 0.78 | 1.04 | 0.139 | |
| CKD baseline disease (ref 1) | 2 | 2.89 | 1.10 | 7.59 | 0.031 | 4.85 | 1.69 | 13.93 | 0.003 | 0.00 | −493.07 | 999.9 | 0.964 |
| CKD baseline disease (ref 1) | 3 | 1.09 | 0.55 | 2.14 | 0.812 | 1.18 | 0.54 | 2.57 | 0.686 | 0.95 | 0.23 | 3.88 | 0.939 |
| CKD baseline disease (ref 1) | 4 | 3.31 | 1.30 | 8.40 | 0.012 | 2.25 | 0.77 | 6.64 | 0.140 | 11.02 | 0.82 | 148.29 | 0.070 |
| CKD baseline disease (ref 1) | 5 | 1.34 | 0.64 | 2.79 | 0.439 | 1.61 | 0.71 | 3.65 | 0.253 | 0.41 | 0.04 | 4.56 | 0.470 |
| CKD baseline disease (ref 1) | 6 | 1.17 | 0.58 | 2.35 | 0.664 | 1.17 | 0.51 | 2.65 | 0.713 | 1.14 | 0.27 | 4.78 | 0.861 |
| CKD baseline disease (ref 1) | 7 | 1.59 | 0.80 | 3.14 | 0.184 | 2.03 | 0.95 | 4.34 | 0.068 | 0.29 | 0.03 | 3.06 | 0.304 |
| CVD (0, no) | 1 | 1.87 | 1.14 | 3.06 | 0.013 | 1.96 | 1.13 | 3.38 | 0.016 | 1.72 | 0.47 | 6.27 | 0.409 |
| DM (0, no) | 1 | 0.79 | 0.42 | 1.48 | 0.460 | 0.85 | 0.43 | 1.66 | 0.626 | 0.72 | 0.08 | 6.75 | 0.770 |
| Donor type (0 deceased; 1 living) | 1 | 0.54 | 0.25 | 1.13 | 0.100 | ||||||||
| Donor age (years) | 1.00 | 0.98 | 1.03 | 0.805 | 1.00 | 0.97 | 1.03 | 0.950 | 1.02 | 0.96 | 1.08 | 0.534 | |
| Donor BMI (years) | 1.00 | 0.96 | 1.03 | 0.762 | 0.99 | 0.95 | 1.04 | 0.786 | 1.00 | 0.95 | 1.05 | 0.933 | |
| CIT (hours) | 1.00 | 0.96 | 1.04 | 0.974 | 0.99 | 0.95 | 1.03 | 0.700 | 1.63 | 1.16 | 2.30 | 0.005 | |
| cPRA (%) | 1.00 | 0.99 | 1.01 | 0.820 | 1.00 | 0.99 | 1.01 | 0.844 | 1.01 | 0.99 | 1.03 | 0.615 | |
| MM DR (n; ref 0) | 1 | 1.02 | 0.62 | 1.67 | 0.939 | 1.04 | 0.61 | 1.79 | 0.884 | 0.98 | 0.24 | 3.99 | 0.977 |
| MM DR (n; ref 0) | 2 | 1.32 | 0.76 | 2.29 | 0.329 | 1.24 | 0.66 | 2.31 | 0.509 | 1.68 | 0.40 | 7.00 | 0.476 |
| UBI | 1.00 | 0.99 | 1.02 | 0.786 | 1.00 | 0.99 | 1.02 | 0.636 | 0.99 | 0.94 | 1.04 | 0.673 | |
| All | Deceased | Living | |||||||||||
| Variables | Baseline disease | OR | CI − 95% | CI + 95% | P-value | OR | CI − 95% | CI + 95% | P-value | OR | CI − 95% | CI + 95% | P-value |
| Death-censored graft loss | |||||||||||||
| Age (years) | 0.97 | 0.95 | 0.99 | 0.002 | 0.99 | 0.95 | 1.02 | 0.492 | 0.96 | 0.93 | 0.99 | 0.004 | |
| Sex (male; ref) | 1 | 0.67 | 0.44 | 1.03 | 0.069 | 0.79 | 0.45 | 1.39 | 0.418 | 0.56 | 0.28 | 1.12 | 0.101 |
| BMI at PKT | 1.03 | 0.98 | 1.08 | 0.273 | 1.04 | 0.98 | 1.11 | 0.168 | 1.00 | 0.92 | 1.09 | 0.982 | |
| CKD baseline disease (ref 1) | 2 | 1.85 | 0.84 | 4.05 | 0.125 | 1.91 | 0.62 | 5.92 | 0.261 | 1.55 | 0.48 | 4.94 | 0.460 |
| CKD baseline disease (ref 1) | 3 | 1.11 | 0.58 | 2.11 | 0.752 | 1.15 | 0.50 | 2.64 | 0.745 | 0.81 | 0.28 | 2.33 | 0.693 |
| CKD baseline disease (ref 1) | 4 | 0.43 | 0.11 | 1.76 | 0.244 | 0.32 | 0.06 | 1.79 | 0.197 | 0.59 | 0.04 | 8.23 | 0.698 |
| CKD baseline disease (ref 1) | 5 | 2.03 | 0.93 | 4.47 | 0.077 | 1.72 | 0.67 | 4.41 | 0.260 | 1.77 | 0.33 | 9.55 | 0.509 |
| CKD baseline disease (ref 1) | 6 | 1.45 | 0.76 | 2.79 | 0.263 | 1.25 | 0.52 | 3.01 | 0.615 | 1.55 | 0.56 | 4.31 | 0.403 |
| CKD baseline disease (ref 1) | 7 | 1.41 | 0.68 | 2.91 | 0.358 | 1.17 | 0.47 | 2.90 | 0.740 | 1.66 | 0.46 | 5.92 | 0.437 |
| CVD (0, no) | 1 | 0.92 | 0.45 | 1.86 | 0.810 | 0.74 | 0.31 | 1.75 | 0.495 | 1.46 | 0.41 | 5.20 | 0.556 |
| DM (0, no) | 1 | 1.39 | 0.70 | 2.78 | 0.349 | 1.26 | 0.58 | 2.76 | 0.561 | 1.82 | 0.37 | 9.02 | 0.464 |
| Donor type (0, deceased; 1, living) | 1 | 0.95 | 0.45 | 2.02 | 0.897 | ||||||||
| Donor age (years) | 1.04 | 1.02 | 1.06 | 0.001 | 1.03 | 1.00 | 1.06 | 0.0543 | 1.0178 | 0.985 45 | 1.05 | 0.285 | |
| Donor BMI (years) | 1.00 | 0.99 | 1.01 | 0.810 | 1.03 | 0.98 | 1.08 | 0.290 | 1.00 | 0.97 | 1.02 | 0.725 | |
| CIT (hours) | 1.01 | 0.96 | 1.05 | 0.752 | 1.00 | 0.96 | 1.05 | 0.986 | 1.30 | 1.03 | 1.63 | 0.027 | |
| cPRA (%) | 1.00 | 0.99 | 1.01 | 0.828 | 1.00 | 0.99 | 1.01 | 0.733 | 1.00 | 0.98 | 1.01 | 0.641 | |
| MM DR (n; ref 0) | 1 | 0.91 | 0.56 | 1.49 | 0.718 | 0.97 | 0.52 | 1.80 | 0.919 | 0.84 | 0.37 | 1.90 | 0.680 |
| MM DR (n; ref 0) | 2 | 1.81 | 1.02 | 3.21 | 0.043 | 2.06 | 1.01 | 4.18 | 0.047 | 1.46 | 0.52 | 4.06 | 0.469 |
| UBI | 1.00 | 0.98 | 1.02 | 0.985 | 1.02 | 0.99 | 1.04 | 0.176 | 0.98 | 0.96 | 1.00 | 0.048 | |
Significant values in bold.
DM: diabetes mellitus; CIT: cold ischaemic time; cPRA: calculated panel reactive antibody; MM: mismatch.
CKD baseline disease: 1, ADPKD; 2, CAKUT; 3, diabetes mellitus; 4, hypertension/RVD; 5, glomerulonephritis; 6, ‘other primary renal disease’; 7, unknown or missing.