Table 3.

MicroRNA Biomarkers

First author/s, year	Biomarker	Marker type	Diagnostic or prognostic utility	(Refs.)
Bandrés et al., 2006	miR-31	MicroRNA	Correlates with advanced stages of colorectal cancer; indicates tumor progression and aggressiveness.	74
Akao et al., 2007	let-7	MicroRNA	Regulates oncogenes like RAS; shows potential as a therapeutic agent to suppress tumor growth.	75
Ma X et al., 2020	miR-199b	MicroRNA	Lower expression in tumors correlates with worse survival; high levels linked to advanced stages.	76
Hur K et al., 2014	miR-17-92 (miR-25, miR-92)	MicroRNA	Overexpression linked to aggressive clinical behavior in MSS tumors.	77

The microRNA table details their regulatory role in CRC biology, including tumor progression, metastasis, and therapy resistance. It highlights specific miRNAs, such as miR-31, associated with advanced cancer stages and aggressiveness, and let-7, which regulates oncogenes like RAS. These markers serve as potential diagnostic and prognostic tools and provide therapeutic opportunities for personalized treatments.