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. Author manuscript; available in PMC: 2025 Jul 29.
Published in final edited form as: Nat Cancer. 2025 May 16;6(6):1073–1087. doi: 10.1038/s43018-025-00968-5

Extended Data Fig. 9 |. αVHH CAR T cells reduce tumor burden of VHH LNP injected tumors.

Extended Data Fig. 9 |

(a) Tumor growth curves of wildtype E0771 (E0771-wt) tumors transfected with VHH-LNPs (CKK-E12) by intratumoral injection of 5 μg mRNA-loaded LNPs without adoptive cell transfer of αVHH CAR T cells. Two-way ANOVA, mean ± s.e.m. is depicted; n = 6 saline injected mice and n = 5 for VHH-LNP injected mice.; n.s. = not significant. (b) Tumor growth curves of wildtype E0771 tumor-bearing mice treated with intratumorally with either saline, Fluc-LNP or VHH-LNP and αVHH CAR T cells on days indicated by a dashed line (D0, D7, D14, D21, and D28). Two-way ANOVA, mean ± s.e.m., n = 5 mice. Saline vs. VHH-LNP: *p = 0.0176, ***p = 0.0006, ****p < 0.0001.