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. 2025 Jun 18;27(29):7767–7772. doi: 10.1021/acs.orglett.5c02006

1. Reaction Optimization for Enantioselective Synthesis.

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a

Yields were not quantified due to volatility of the products.

b

Enantiomeric ratio was measured by chiral HPLC of the p-nitrobenzoate ester derivative of the products. See Supporting Information.

c

Products were formed with >20:1 diastereomeric ratio based on 1H NMR analysis of the crude reaction mixtures.