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. 2002 Jun 4;99(12):8306–8311. doi: 10.1073/pnas.122225199

Figure 3.

Figure 3

Inhibition of GTN (1 μM) biotransformation by ALDH inhibitors and tolerance induction in rabbit aorta. (a) Concentration-dependent inhibition of 1,2-GDN formation by chloral hydrate (●), cyanamide (■), and acetaldehyde (▴). Activities are presented as the percentage of control rings (without inhibitor treatment). Data are the average of two experiments. (b) 1,2-GDN formation is reduced in tolerant vessels relative to control (P < 0.01). Data are the means ± SD of three experiments. (c) mtALDH activity is inhibited in tolerant vessels (P < 0.01). Data are the means ± SD of three experiments.