Table 3.
Polysomnography Parameters of Restless Legs Syndrome Patients for Whom the Drugs Were Effective or Ineffective
| Variables/Parameters | Pramipexole | Pregabalin | ||||||
|---|---|---|---|---|---|---|---|---|
| Effective (n = 94) | Ineffective (n = 70) | χ2/t/z value | P-value | Effective (n = 61) | Ineffective (n = 32) | χ2/t/z value | P -value | |
| Polysomnography parameters | ||||||||
| Total sleep time (minutes), median (IQR) | 394.5 (312, 451.5) | 407.5 (329.1, 447.9) | −0.347 | 0.730 | 385.5 (340.0, 459.5) | 422.75 (295.25, 458.5) | −0.347 | 0.728 |
| Sleep efficiency (%), median (IQR) | 73.1 (59.28, 85.6) | 72.85 (64.53, 82.7) | −0.071 | 0.944 | 72.91 (58.30, 84.11) | 75.71 (62.18, 84.02) | −0.631 | 0.528 |
| Wake time after sleep onset (minutes), median (IQR) | 113.5 (55.25, 198.5) | 122.75 (79.75, 170.63) | −0.070 | 0.945 | 128 (72.13, 195.88) | 103.25 (54.13, 163.13) | −1.084 | 0.278 |
| Sleep latency (minutes), median (IQR) | 21.5 (9.25, 42) | 16.75 (10, 41.25) | −0.249 | 0.804 | 15.5 (8, 43.25) | 23 (9, 35.75) | −0.340 | 0.730 |
| REM sleep latency (minutes), median (IQR) | 102.5 (72, 165.5) | 119.5 (78.63, 195.63) | −1.546 | 0.123 | 99.25 (71.38, 157) | 65.25 (54.5, 108.13) | −2.370 | 0.018* |
| N1 (%), median (IQR) | 6.8 (3.85, 11.8) | 5.94 (3.375, 9.11) | −0.913 | 0.363 | 9.05 (4.6, 19.43) | 9.15 (3.28, 13.1) | −1.383 | 0.167 |
| N2 (%), mean ± SD | 43.28 ± 14.95 | 50.63 ± 14.58 | −3.143 | 0.535 | 43.84 ± 12.15 | 43.82 ± 15.57 | 0.003 | 0.139 |
| N3 (%), mean ± SD | 26.62 ± 13.52 | 23.38 ± 11.66 | 1.608 | 0.148 | 24.36 ± 11.56 | 26.48 ± 11.51 | −0.838 | 0.847 |
| REM (%), mean ± SD | 19.15 ± 7.06 | 17.98 ± 7.09 | 1.043 | 0.876 | 18.59 ± 7.04 | 18.90 ± 8.06 | −0.193 | 0.544 |
| AHI, median (IQR) | 3.83 (1.5, 11.73) | 3.64 (1.98, 8.29) | −0.414 | 0.680 | 6.47 (1.84, 47.75) | 4.56 (2.29, 7.84) | −1.420 | 0.155 |
| PLMS index (/h), median (IQR) | 7.54 (0.8, 30.66) | 7.85 (1.03, 24.01) | −0.419 | 0.677 | 3.01 (0, 16.15) | 1.19 (0, 12.47) | −1.180 | 0.238 |
Notes: * P < 0.05.
Abbreviations: IQR, interquartile range; REM, rapid eye movement; SD, standard deviation; AHI, apnea-hypopnea index; PLMS, periodic leg movements during sleep.