Table 3.
In vivo competitions
| Strain | Infant mice
|
Previously tested animal models
|
||||
|---|---|---|---|---|---|---|
| Rodents
|
Piglets
|
|||||
| No. of mice | C.I. | Colonization | Ref. | Colonization | Ref. | |
| copA∷cat AH244* | 4 | 0.98 ± 0.19 | + | 17 | NA | |
| vacA∷kan G27 SmR-1 | 5 | 0.98 ± 0.25 | +, +/− | 24, 25 | + | 26 |
| ggt∷kan G27 SmR-1 | 4 | 0.93 ± 0.55 | +/−, − | 27, 28 | +/− | 28 |
| motB∷kan G27† | 6 | 0.33 ± 0.09 | +/−, − | 22, 29, 30 | − | 31 |
| cheY∷kan G27 | 5 | 0.26 ± 0.07 | − | 32 | − | 32 |
| HP0507∷kan G27 SmR-1 | 4 | 0.03 ± 0.02 | NA | NA | ||
| frdA∷cat AH244* | 6 | <4.5 × 10−4 | − | 17 | NA | |
| ureA∷kan G27 SmR-14 | 4 | <4.4 × 10−4 | − | 33 | − | 34 |
Competitive index (C.I.) = (cfu muant/cfu WT) output/(cfu mutant/cfu WT) input. SDs are shown. Mutants with a C.I. <0.5 are considered attenuated. NA, data not available. +, colonization same as WT. +/−, colonization lower than WT. −, no colonization.
*
Same mutant as used in reference.
† Same phenotype as mutants used in reference(s). All other mutants have an insertion in the same gene, but in a different strain background than used in the reference(s).