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. 2025 Jul 16;16:1624655. doi: 10.3389/fimmu.2025.1624655

Table 3.

Multivariable logistic regression analysis of predictors of 28-day mortality in the prospective cohort.

Variables Unadjusted Adjusted
OR (95% CI) p value OR (95% CI) p value
APACHE-II 1.07 (1.04-1.10) p<.001 1.08 (1.05-1.11) p<.001
HR 1.01 (1.00-1.02) p=.008 1.01 (1.00-1.02) p=.002
RR 1.02 (0.99-1.04) p=.131 1.02 (1.00-1.04) p=.073
OI 1.00 (1.00-1.00) p=.212 1.00 (1.00-1.00) p=.170
Lactate 1.04 (0.98-1.10) p=.167
Admission Source
 Elective Surgical
 Medical 1.95 (1.13-3.36) p=.016 1.90 (1.13-3.19) p=.016
 Emergency Surgical 1.20 (0.64-2.24) p=.566 1.18 (0.64-2.17) p=.604
Pulmonary Infection
 No
 Yes 2.00 (1.25-3.21) p=.004 1.96 (1.23-3.14) p=.005
TLC 1.00 (1.00-1.00) p=.090
CD4+TLC 1.00 (1.00-1.00) p=.101
NK LC 1.00 (0.99-1.00) p=.067 1.00 (0.99-1.00) p=.046
FI-lab, risk
 Low frailty risk
 Intermediate frailty risk 1.34 (0.78-2.30) p=.289 1.40 (0.82-2.39) p=.218
 High frailty risk 2.17 (1.28-3.66) p=.004 2.31 (1.39-3.84) p=.001

*Compared between the patients with pulmonary infection vs. non-pulmonary.

OR, odds ratio; CI, confidence interval; APACHE-II, Acute Physiology and Chronic Health Evaluation II; HR, heart rate; T, temperature; RR, respiratory rate; OI, oxygenation index; TLC, T-lymphocyte count; NK LC, natural killer lymphocyte count; FI-lab, the Frailty Index based on routine laboratory tests.

P values <0.05 were displayed in bold and considered as independent predictors of 28-day mortality.