Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A summary P-glycoprotein (P-gp) interactions of ARPIs and their implications for relugolix
| ARPI | P-gp interaction | Implications for relugolix |
|---|---|---|
| Abiraterone | Inhibits P-gp | May increase relugolix exposure, potentially enhancing its effects and side effects. |
| Apalutamide | Induces P-gp | May reduce relugolix levels. |
| Darolutamide | Substrate and weak inhibitor of P-gp | Minimal effect on relugolix expected. |
| Enzalutamide | Induces P-gp | May lower relugolix plasma concentration. |
