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. 2025 May 26;20(4):597–613. doi: 10.1007/s11523-025-01151-7
Prostate-specific membrane antigen positron emission tomography (PSMA PET) imaging may help to identify patients who will benefit from PSMA-targeted radioligand therapy.
Whilst the increased use of PSMA PET imaging and PSMA-targeted radioligand therapy has improved patient outcomes, there is a growing need for guidance that can further optimize its use. This review provides an overview of the clinical considerations for the use of PSMA PET, such as identifying patients eligible for radioligand therapy and guidance for using PSMA PET in the clinic.