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. 2002 Jun 11;99(12):8384–8388. doi: 10.1073/pnas.122149199

Figure 1.

Figure 1

eCBs mediate LTD in the NAc. (A) Typical experiment where tetanic stimulation (13 Hz during 10 min) of prelimbic cortical afferents induced a LTD of eEPSC (see Fig. 2B for averaged data). (Inset) Superimposed traces (average of 10 consecutives eEPSCs) taken at time indicated on graph. (Bar = 20 msec, 200 pA.) (B) Typical experiment showing saturation of 13-Hz LTD (as observed in four other experiments). (C) LTD is eliminated in slices perfused with the CB1 antagonist SR141716A (1 μM) (fEPSP was 96.3 ± 3.4% of baseline at 60 min in the presence of antagonist; n = 11, P <0.05 vs. control without antagonist). (D) 13-Hz LTD is eliminated in CB1−/− mice, compared with their wild-type littermates. fEPSP 60 min after tetanus measured 104.2 ± 5.1% of baseline in CB1−/− and 82.7 ± 3.8% in CB1+/+, P < 0.05.