Table 3.
In vitro inhibition of BuChE and AChE by compounds isolated from Buxus macowanii.
| Phytoconstituent | Structure |
IC50 (µM)
BuChE |
IC50 (µM)
AChE |
Selectivitya | References |
|---|---|---|---|---|---|
| Buxbodine |
|
N.D. | 50.0 | - | [43] |
| Buxmicrophylline C |
|
N.D. | 20.0 | - | [43] |
| Nb-demethylpapillotrienine |
|
N.D. | 19.0 | - | [43] |
| 16α-Hydroxymacowanitriene |
|
N.D. | 11.4 | - | [43] |
| Macowanitriene | N.D. | 10.8 | - | [43] | |
| Irehine |
|
N.D. | 98 | - | [43] |
| 31-Hydroxybuxatrienone |
|
N.D. | 17.0 | - | [43] |
| Macowamine |
|
N.D. | 45.0 | - | [43] |
| Macowanioxazine |
|
N.D. | 32.5 | - | [43] |
| Moenjodaramine | - | 27.0 | - | [43] |
Note: aSelectivity = IC50 BuChE/IC50 AchE.