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Disruption of the interaction between CNGA1 and CNGB1 by Ca2+/CaM. (A) Bait proteins derived from CNGB1 (red) and fish protein derived from CNGA1 (blue). (B) Western blot of pull-down experiments with the bait protein CNGB1#677–764 and the fish protein CNGA1#609–693, in the presence of EDTA, Ca2+, or CaM. (C) An intersubunit interaction between the distal C-terminal domain of CNGA1 and an N-terminal domain of CNGB1 and prevention of the interaction by Ca2+/CaM.
