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. 2002 May 28;99(12):8430–8435. doi: 10.1073/pnas.122682899

Figure 6.

Figure 6

GIRK2(E315A) can assemble with GIRK1. Double mutant GIRK2(V188A, E315A) was cotransfected together with GIRK2(V188A) to test whether the double mutant GIRK2(V188A, E315A) competes with GIRK2(V188A) for GIRK1. The current produced by GIRK2(V188A)/GIRK1 was large (left bar). The current produced by GIRK2(V188A, E315A)/GIRK1 was very small (right bar). Transfection of GIRK2(V188A) plus GIRK2(V188A, E315A) together with GIRK1 produced an intermediate size of current, suggesting that GIRK2(V188A) and GIRK2(V188A, E315A) compete with each other for GIRK1. *, P < 0.05 in reference to V188A (nonparametric ANOVA with the Bonferroni post test).