Table 2.
Variables according to fibrosis stages stratified by magnetic resonance elastography, n (%)
| Variables | No or mild fibrosis (group 1) [Median (IQR)] | Significant fibrosis (group 2) [Median (IQR)] | Cirrhosis (group 3) [Median (IQR)] |
P value1
|
|||
|
Group 1 vs group 2
|
Group 2 vs group 3
|
Group 1 vs group 3
|
All
|
||||
| Age (years) | 49 (40.75-56.00) | 53 (42-61.75) | 52 (43-62) | 0.0604 | 0.9999 | 0.2393 | 0.06 |
| Sex | |||||||
| Male | 55 (61.1) | 94 (57) | 29 (67.4) | ND | ND | ND | ND |
| Female | 35 (38.9) | 71 (43) | 14 (32.6) | ND | ND | ND | ND |
| Aspartate aminotransferase (U/L) | 27 (21.84-36.25) | 31 (22-45) | 34.5 (25.25-53) | 0.0724 | 0.0075 | 0.341 | 0.0062 |
| Alanine aminotransferase (U/L) | 31 (22.75-64.5) | 45.5 (25-72.25) | 47.5 (29-73.75) | 0.1252 | > 0.9999 | 0.2029 | 0.0741 |
| Gamma glutamyl transferase (U/L) | 58.5 (34-110.5) | 70.5 (37.25-119) | 84 (54-151) | 0.6769 | 0.0987 | 0.0144 | 0.0187 |
| Body mass index (kg/m2) | 26.63 (24.4-28.9) | 26.3 (24.4-28) | 27 (24.8-31) | > 0.9999 | 0.1613 | 0.2832 | 0.1449 |
| FibroScan (kPa) | 6.3 (5.78-7.7) | 8 (7.03-9.5) | 11 (7.1-15.7) | < 0.0001 | 0.0018 | < 0.0001 | < 0.0001 |
| Fibrosis-4 Index | 0.76 (0.57-1.00) | 0.95 (0.67-1.35) | 1.18 (0.7-1.79) | 0.0092 | 0.2237 | 0.0007 | 0.0004 |
| Aspartate aminotransferase-to-platelet ratio index | 0.26 (0.19-0.36) | 0.32 (0.21-0.46) | 0.33 (0.21-0.62) | 0.023 | > 0.9999 | 0.029 | 0.0073 |
| Mac-2 binding protein glycosylation isomer (cut-off index) | 0.57 (0.45-0.81) | 0.68 (0.52-0.9) | 0.78 (0.58-1.17) | 0.038 | 0.39 | 0.005 | 0.0035 |
| Hemoglobin A1c | 5.78 (5.45-6.31) | 6 (5.59-6.8) | 5.92 (5.65-7.52) | 0.0344 | > 0.9999 | 0.1148 | 0.0241 |
| Glucose (mmol/L) | 5.85 (5.49-6.59) | 6.42 (5.69-7.55) | 6.42 (5.66-9.02) | 0.0083 | > 0.9999 | 0.0243 | 0.0041 |
| Low density lipoprotein-cholesterol (mmol/L) | 3.35 (2.61-4.19) | 3.13 (2.45-4.1) | 3.7 (2.62-4.59) | > 0.9999 | 0.2192 | 0.9231 | 0.1824 |
| Triglycerides (mmol/L) | 2.29 (1.62-3.22) | 2.43 (1.75-3.68) | 2.08 (1.73-3.28) | 0.8688 | > 0.9999 | > 0.9999 | 0.4874 |
| Total cholesterol (mmol/L) | 5.3 (4.66-6.17) | 5.24 (4.37-6.22) | 5.57 (4.84-6.74) | > 0.9999 | 0.5871 | > 0.9999 | 0.4242 |
| Comorbidity | |||||||
| Hyperglycemia | 20 (22.2) | 71 (42.3) | 22 (51.2) | ND | ND | ND | ND |
| Diabetes | 15 (16.7) | 52 (31) | 16 (37.2) | ND | ND | ND | ND |
| Obesity | 12 (13.3) | 20 (11.9) | 12 (27.9) | ND | ND | ND | ND |
1
Dunn’s test was performed to compare individual groups in post-hoc analysis, P < 0.05.
ND: Not done; IQR: Interquartile range.