. Author manuscript; available in PMC: 2026 Jan 1.

Published in final edited form as: Epidemiology. 2024 Sep 24;36(1):66–75. doi: 10.1097/EDE.0000000000001789

Table 2.

Interaction Analysis on Mortality and Hospitalization rates across marginalized Down syndrome (DS) groups

Mortality Rate looking at Race and Down syndrome as an interaction
Race^a	Mortality Rate (IRR)	RERI^b	95 % CI
White no DS	1.00
White DS	1.30
Black no DS	0.80
Black DS	3.27	-0.20	(−0.24, −0.15)

White no DS	1.00
White DS	3.73
Pacific Islander no DS	0.65
Pacific Islander DS	4.02	0.65	(0.46, 0.83)

White no DS	1.00
White DS	3.75
Asian no DS	0.41
Asian DS	3.25	0.10	(−0.02, 0.22)

White no DS	1.00
White DS	3.73
Native no DS	1.05
Native DS	3.28	-0.50	(−0.71, −0.29)

White no DS	1.00
White DS	3.74
Mixed no DS	0.47
Mixed DS	2.88	-0.33	(−0.44, −0.21)

Ethnicity^a	Mortality Rate (IRR)	RERI^b	95 % CI
Non-Hispanic no DS	1.00
Non-Hispanic DS	3.83
Hispanic no DS	0.58
Hispanic DS	3.31	-0.10	(−0.15, −0.04)

Hospitalization Rate looking at Ethnicity and Down syndrome as an interaction
Race^a	Hospitalization Rate (IRR)	RERI^b	95 % CI
White no DS	1.00
White DS	1.16
Black no DS	1.14
Black DS	1.53	0.22	(0.19, 0.25)

White no DS	1.00
White DS	1.18
Pacific Islander no DS	0.94
Pacific Islander DS	1.61	0.49	(0.37, 0.61)

White no DS	1.00
White DS	1.19
Asian no DS	0.67
Asian DS	1.38	0.52	(0.46, 0.59)

White no DS	1.00
White DS	1.18
Native no DS	1.28
Native DS	1.46	0.01	(−0.13, 0.14)

White no DS	1.00
White DS	1.18
Mixed no DS	1.00
Mixed DS	1.32	0.14	(0.08, 0.19)

Hospitalization Rate looking at Ethnicity and Down syndrome as an interaction
Ethnicity^a	Hospitalization Rate	RERI^b
Non-Hispanic no DS	1.00
Non-Hispanic DS	1.21
Hispanic no DS	1.08
Hispanic DS	1.39	0.10	(0.07, 0.13)

Adjusted for sex, age, and region

Relative Excess Risk due to Interaction