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. 2005 Oct;73(10):6299–6310. doi: 10.1128/IAI.73.10.6299-6310.2005

TABLE 1.

Assessment of histopathological features after infection with different strains of M. ulcerans

Histopathological parameter M. ulcerans strain No. of positive cases/total studied cases on postinfection day:
2 7 15 24 43 60
Acute inflammation (predominant neutrophilic infiltrate) 98-912 5/5 2/6 6/6 6/6 a
97-1116 3/3 4/6 5/6 6/6 2/2
5114 3/3 2/6 0/6 0/5 NDb 0/6
Chronic inflammation (predominant macrophagic-lymphocytic infiltrate) 98-912 0/5 4/6 0/6 0/6
97-1116 0/3 1/6 1/6 0/6 0/2
5114 0/3 4/6 6/6 5/5 ND 6/6
Presence of granuloma-like structures 98-912 0/5 0/6 0/6 0/6
97-1116 0/3 0/6 0/6 0/6 0/2
5114 0/3 0/6 6/6 5/5 ND 6/6
Leukocyte destruction (apoptosis/necrosis) 98-912 5/5 6/6 6/6 6/6
97-1116 3/3 6/6 6/6 6/6 2/2
5114 0/3 0/6 0/6 0/5 ND 0/6
Subcutaneous tissue necrosis 98-912 0/5 0/6 3/6 6/6
97-1116 0/3 0/6 3/6 6/6 2/2
5114 0/3 0/6 0/6 0/5 ND 0/6
a

—, animals were sacrificed after emergence of ulceration.

b

ND, not done.

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