TABLE 4.

Influence of traP, agr, and sar on virulence determinants^a

Virulence determinant	Gene	Influence of:
		traP	agr	sarA
Exotoxins
Aureolysinc	aur	+	+	−
Capsular polysaccharide type 5 genes	cap	+	+	+
V8 proteasec	sspA	+	+	−
Toxic shock syndrome toxin	tst	unknown	+	+
Glycerol ester hydrolase	geh	+	+	+
α-Hemolysinb,e	hla	+	+	+
β-Hemolysinb	hlb	+	+	+
γ-Hemolysin	hlgB	+	+	+
δ-Hemolysinc,e	hld	+	+	+
Hyaluronate lyase	hysA	+	+	Unknown
Lipase	lip	+	+	−
Holin-like proteins	lrgB	+	+	+
1-Phosphatidylinositol phosphodiesterase	plc	+	+	Unknown
Surface-adhesion molecules
Protein Ac,d,e	spa	−	−	−
Coagulase	coa	Ø	+/−	+
Fibrinogen-binding proteine	sdrC	Microarray −	Unknown	+
		Real time +
Fibrinogen-binding proteine	sdrD	Microarray −	Unknown	Unknown
		Real time +
Ica operon transcriptional regulator IcaRe	icaR	Microarray Ø	Ø	Ø
		Real time +/−
Intracellular adhesin Ae	icaA	Microarray Ø	Ø	+
		Real time +/−
Clumping factor Be	clfB	Microarray +/−	Ø	+
		Real time −
Collagen-binding protein	cna	Ø	+/−	−
Fibronectin-binding protein	fnbAB	Ø	−	+

^aThe influence of traP is as determined in studies described here and the influence of agr and sar is as previously determined (7, 8, 13). Ø, not influenced; +, increased; −, decreased; +/−, marginal change; unknown, gene is absent in the examined strain or the gene array or unreported.

^bConfirmed by Northern blotting.

^cConfirmed by cDNA-PCR.

^dConfirmed by two-dimensional gel electrophoresis.

^eConfirmed by real-time PCR.