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. 2005 Oct;73(10):6962–6973. doi: 10.1128/IAI.73.10.6962-6973.2005

TABLE 1.

Transcriptional analysis of MMP and TIMP genes

Gene Mean expression on indicated day postinfectiona
4
7
10
14
21
28
35
56
C57 C3H C57 C3H C57 C3H C57 C3H C57 C3H C57 C3H C57 C3H C57 C3H
Collagenase-A NC NC 0.5 NC NC 2.9 NC NC NC 2.1 NC 0.1 0.2 NC 0.4 NC
MMP-10 NC 1.6 NC 2.1 NC 3.0 NC 1.8 NC 2.5 0.5 0.5 0.5 1.5 0.1 0.2
MMP-11 NC NC NC NC NC 2.1 NC NC NC NC NC NC 0.5 2.1 NC 0.3
MMP-12 NC 2.2 0.5 2.0 NC 2.6 0.4 NC 0.2 3.9b 0.3 0.3 0.3 1.8 0.4 NC
MMP-13 NC 13.9b NC 28.6b NC 23.5b NC 15.4b 0.5 30.3b NC NC NC 3.5 0.3 NC
MMP-14 NC NC NC NC NC NC NC NC NC NC 0.5 NC NC NC NC NC
MMP-15 NC 3.5 NC NC NC 3.2 NC 1.9 0.4 5.5b 0.4 NC 0.3 2.6 0.3 1.6b
MMP-16 NC NC NC NC NC NC NC NC 0.5 NC NC NC NC NC 0.5 NC
MMP-17 NC 2.0 NC 2.0 NC NC NC 1.8 NC 1.5 0.5 0.3 0.5 2.0 0.1b NC
MMP-19 NC NC NC NC NC NC NC NC NC 1.5 0.5 NC 0.5 NC NC NC
MMP-2 NC NC NC NC NC NC NC NC NC NC NC NC NC NC 0.5 NC
MMP-20 NC 2.3 NC 2.2 NC NC NC NC NC 2.1 NC NC 0.4 2.0 0.3 NC
MMP-23 NC NC NC NC NC NC NC NC 0.5 NC 0.2 0.3 0.4 NC 0.4 NC
MMP-24 NC 1.8 NC NC NC NC NC NC NC NC 0.2 NC 0.4 NC 0.3 0.5
MMP-3 NC 1.8 1.8 3.3 NC 1.9 NC NC NC 1.8 NC NC NC NC 0.3 NC
MMP-7 NC NC NC 0.4 NC NC NC 0.3 NC NC 0.4 0.4 NC NC 0.4b 0.2
MMP-8 NC 3.6 NC 1.5 NC NC NC NC NC NC NC NC NC NC 0.5 0.3
MMP-9 NC 4.1b NC 4.3b NC 3.0 NC 1.8 2.2 3.0 NC NC NC 1.6 0.5 NC
TIMP-1 NC NC 1.5 3.0 NC 2.4 0.5 2.2 NC 2.0 0.2 NC NC NC NC 2.2
TIMP-2 NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
TIMP-3 NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC NC
TIMP-4 NC NC NC NC NC NC NC NC NC NC NC 0.3 NC NC NC NC
a

Values are the mean of four to six mice per time point in two or three different experiments (depending on the time point) and are expressed relative to P4 pretreatment from day 0 (uninfected), where 1.0 equals day 0 values. We arbitrarily considered a relative increase in expression as ≥1.5 (50% or more above day 0), whereas a decrease in expression was considered ≤0.5 (50% or more below day 0). Hence, a 0.5 to 1.5 (50% decrease to 50% increase) expression value relative to day 0 was considered no change (NC).

b

Significant difference between mouse strains at the specified time point was observed using a two-sided t test. P values varied but in each case were <0.5.