FIG. 4.
Comparison of CFU/g kidney 5 days after i.v. infection with ∼5 × 108 CFU of three strains of S. aureus with either a wild-type (WT) ica locus (⧫), the Δica strain with the WT ica locus placed back into the chromosome (complemented [Comp] strain) (▪), or the Δica strain (▴). For S. aureus strains MN8 and 10833, we also performed infections with the sarA::erm strain (ΔsarA) (•). Each point is the result from one mouse. The lower limit of detection is 10 CFU/g kidney. Kidneys in mice found dead were not analyzed for CFU/g due to postmortem effects on bacterial levels. Overall ANOVA for results with all three strains gave a P value of <0.001. The results of pairwise comparisons for each strain using Tukey's multiple-comparison test are shown. P values of <0.05 are highlighted in boldface type.