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. 2025 Jul 30;224(10):e202411138. doi: 10.1083/jcb.202411138

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© 2025 Padman et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure S4. — AIVE of mouse skeletal muscle. (A–C) AIVE reconstruction of mouse skeletal muscle tissue revealing mitochondrial nanotunnel connections. (A) 3D rendering depicting myofibrils (red), mitochondria (purple), and sarcoplasmic reticulum (gold) within a volume measuring 8 × 8 × 6.2 µm FIB-SEM volume, with (B) a rendered cutaway displaying the interconnectivity of mitochondria within the tissue (mitochondrial nanotunnels indicated by black arrowheads). (C) Representative example of one nanotunnel linking the mitochondrial network around a myofibril. See Video 7 for an animated depiction of data in A–C. Scale bars; A–C, as indicated within figure.