TABLE 1.
Protection against B. melitensis or B. ovis in BALB/c mice immunized with the Omp31 DNA vaccine
| Treatment group (n = 8) |
B. melitensis
|
B. ovis
|
||||||
|---|---|---|---|---|---|---|---|---|
| Mean log10 CFU ± SD in:
|
Log U of protection in:
|
Mean log10 CFU ± SD in:
|
Log U of protection in:
|
|||||
| Spleen | Liver | Spleen | Liver | Spleen | Liver | Spleen | Liver | |
| PBS | 5.75 ± 0.16 | 2.53 ± 0.16 | 0 | 0 | 4.83 ± 0.17 | 3.12 ± 0.08 | 0 | 0 |
| pCI | 5.74 ± 0.30 | 2.20 ± 0.68 | 0.01 | 0.33 | 4.82 ± 0.30 | 3.02 ± 0.08 | 0.01 | 0.10 |
| pCIOmp31 | 4.45 ± 0.60a | 1.53 ± 0.23a | 1.30 | 1.00 | 2.59 ± 0.25a | 2.49 ± 0.18a | 2.24 | 0.63 |
| H38 | 3.75 ± 0.57a | 1.41 ± 0.08a | 2.00 | 1.12 | 2.22 ± 0.57a | 2.29 ± 0.02a | 2.61 | 0.83 |
a
Significantly different (P < 0.001) from PBS-immunized mice as estimated by Dunnett's test.