TABLE 2.
Protection against B. melitensis infection induced by pCIOmp31 immunization is mediated mainly by CD8+ T cells
| Vaccine group (n = 8) | Treatment | Mean log10B. melitensis CFU ± SD in spleen | Log U of protection |
|---|---|---|---|
| pCI | None | 5.43 ± 0.51 | 0 |
| pCIOmp31 | None | 3.98 ± 0.84b | 1.45 |
| Anti-CD4+ | 4.33 ± 0.63a | 1.10 | |
| Anti-CD8+ | 4.80 ± 0.60c | 0.63 | |
| IgG | 4.01 ± 0.52b | 1.42 | |
| H38 | None | 3.11 ± 0.40b | 2.32 |
a
Significantly different from pCI-immunized mice (P < 0.05) as estimated by Dunnett's test.
b
Significantly different from pCI-immunized mice (P < 0.001) as estimated by Dunnett's test.
c
Significantly different from pCIOmp31-immunized mice (P < 0.05) as estimated by Dunnett's test.