TABLE 3.

Unadjusted median antibody responses by disease state^a

Antigen	Disease state	Median	Range		P value
			Min	Max
Rv2626c	Active	0.245	0.09	1.09	<0.001**
	Inactive	0.178	0.02	1.38	NA
	CXR-normal	0.185	0.02	1.15	0.356
FdxA	Active	0.176	0.06	1.76	0.284
	Inactive	0.164	0.01	1.95	NA
	CXR-normal	0.107	0.02	0.81	<0.001**
AlaDH	Active	0.199	0.07	1.23	0.005*
	Inactive	0.140	0.01	3.56	NA
	CXR-normal	0.106	0.01	1.08	0.001**
38-kDa Ag	Active	0.510	0.01	3.90	0.020*
	Inactive	0.260	0.01	3.99	NA
	CXR-normal	0.155	0.01	2.01	0.002**
ESAT-6	Active	0.090	0.01	3.86	<0.001**
	Inactive	0.210	0.02	3.98	NA
	CXR-normal	0.065	0.01	2.26	<0.001**
16-kDa Ag	Active	0.050	0.01	3.81	<0.001**
	Inactive	0.140	0.01	3.60	NA
	CXR-normal	0.050	0.01	0.58	<0.001**

^aIn this analysis, no attempt was made to separately evaluate active TB patients according to different culture and sputum smear results, given the small sizes of the resulting subgroups (7 active TB patients were culture and smear positive, 31 were culture positive and smear negative, and the remaining 15 were negative by both tests). Values of median and range (minimum and maximum) are shown since the antibody distributions were not normally distributed. The Kruskal-Wallis test was used to calculate P values for comparisons of inactive TB with active TB and of inactive TB with CXR-normal. NA, not applicable (inactive TB was the reference state in this analysis). * denotes differences that are statistically significant at an alpha of 0.05; ** denotes differences that are statistically significant at an alpha of 0.003. Alpha was selected according to the Bonferroni criterion, since the analysis included eight antibodies and two comparisons: inactive versus active and inactive versus CXR-normal [0.003 ≈ 0.05/(2 × 8)].