TABLE 4.

Genes present in four clone array pools that provided protection against colonization of mouse tissues with M. avium subsp. paratuberculosis

General category	Open reading frame	Predicted function	Protective clone arrays
			Array 1	Array 2	Array 4	Array 9
Transport/binding proteins	MAP0448	FisH membrane chaperone	X			X
	MAP1301	ChaA calcium/proton antiporter			X	X
	MAP1308	Lgt lipoprotein transferase	X			X
	MAP2491	OppA oligopeptide transport			X	X
	MAP3498c	Ctpl magnesium transport	X			X
Membrane proteins	MAP1239c	MmpL4.2 membrane protein			X	X
	MAP1493c	Integral protein		X		X
	MAP1912	Membrane protein	X			X
	MAP2239	Membrane protein	X		X
	MAP3049c	Mmpl.2 large membrane protein	X	X
	MAP3131	Large membrane protein			X	X
	MAP3171c	FisX membrane protein		X	X
Virulence proteins	MAP0047c	Proline-rich antigen	X		X	X
	MAP1003c	PE/PPE family protein		X		X
	MAP2191	Mce4 macrophage cell entry		X		X
	MAP2192	Mce4 macrophage cell entry	X	X		X
	MAP3737	PPE family protein	X		X	X
Mycobactin/polyketide synthase	MAP1796c	Pks12 polyketide synthase	X	X
	MAP1871c	Polyketide synthase	X			X
	MAP2171c	MbtF mycobactin/exochelin		X		X
	MAP2174c	MbtD mycobactin/exochelin		X	X	X
	MAP2175c	MbtC mycobactin/exochelin			X	X
	MAP2230c	Polyketide synthase	X	X		X
	MAP2604c	Polyketide synthase			X	X
	MAP3742	Polyketide synthase		X		X
	MAP3764c	Pks2 polyketide synthase	X		X	X