FIG. 4.
Intracellular multiplication of Brucella spp. is not affected by the absence of PrPC in macrophages. Bone marrow macrophages from PrP−/− mice and from congenic C57BL/6 controls were differentiated and infected as described in Material and Methods. The figure shows the mean of three independent experiments. (A) Intracellular multiplication of B. suis. (B) Intracellular multiplication of B. abortus. WT, macrophages derived from control C57BL/6 mice; PrP−/−, macrophages derived from PrP knockout mice.