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. 2025 Jul 23;6(3):103978. doi: 10.1016/j.xpro.2025.103978

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© 2025 The Authors

This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Expected results: Metastasis burden quantification

(A) Quantification of percentage of total brain metastatic area in an experiment performed injecting Nras∗ 1014 cells in vehicle or tamoxifen treated Cx3cr1YFPCreERT2-Rela^fl/fl mice. N = 9 animals per condition. Results are presented as mean ± SEM and differences between the two experimental groups were tested by Student’s t-test. ∗, p<0.05.

(B) Bright field image obtained by scanning a complete slide containing brain sections from mice injected with a pigmented melanoma cell lined along with a close-up picture for detail.

(C) Fluorescence image obtained by scanning a complete slide containing brain sections from mice injected with a non-pigmented TdTomato expressing melanoma cell line along with a close-up picture for detail.