Table 2.

Univariate and multivariate analysis of prognostic factors for death in patients with diffuse hemispheric glioma, H3 G34 mutant (Cox regression).

		Univariate analysis				Multivariate analysis
	n (events)	HR (95 % CI)		P value	n (events)	HR (95 % CI)	P value
Age
<18 years	26 (18)	1.42 (0.82-2.44)		.212	13 (9)	1.58 (0.71-3.52)	.261
≥18 years	86 (53)	1		ref	61 (38)	1	ref
Sex
Female	38 (17)	0.40 (0.23-0.69)		.001	31 (12)	0.43 (0.21-0.87)	.019
Male	74 (54)	1		ref	43 (35)	1	ref
KPS
<70%	14 (9)	1.92 (0.90-4.08)		.092	11 (8)	1.05 (0.32-3.45)	.937
70-80%	27 (17)	1.20 (0.66-2.20)		.552	24 (15)	0.94 (0.43-2.06)	.879
90-100%	45 (29)	1		ref	39 (24)	1	ref
No data	26	-		-	-
Extent of resection
Gross total	37 (25)	0.52 (0.29-0.93)		.028	28 (19)	0.31 (0.12-0.79)	.014
Incomplete	33 (21)	0.77 (0.42-1.40)		.384	22 (15)	0.40 (0.16-1.05)	.062
Biopsy/Autopsy	35 (22)	1		ref	24 (13)	1	ref
No data	7	-		-	-
MGMT promoter status
Methylated	77 (43)	0.52 (0.30-0.89)		.018	53 (29)	0.51 (0.23-1.13)	.098
Unmethylated	26 (20)	1		ref	21 (18)	1	ref
No data	9	-		-	-
First-line treatment
No therapy	6 (4)	1		ref	4 (4)	1	ref
Any therapy	99 (63)	0.02 (0.03-0.70)		<.001	70 (43)	0.27 (0.03-0.14)	<.001
No data	7	-	-		-

Survival data are missing in N = 2 patients.

CI, confidence interval; HR, hazard ratio; KPS, Karnofsky performance status; MGMT, O⁶-methylguanine DNA methyltransferase.