FIG. 6.

Structure of R1. Stereo views of the family of the 20 lowest-energy structures, showing regions covering residues Glu4 to Lys11 (A) and Gly13 to Ile18 (B). Structures were superimposed over the backbone heavy atoms (N, Cα, C′) of residues 5 to 10 (A) and 13 to 17 (B), respectively. In both structured regions, residues in the second and third positions of the turn-like conformations are labeled (Ser14-Arg15 and Leu8-Phe9). (C) Connolly surface representation of R1. The closest-to-average structure from the family of 20 structures is shown. Hydrophobic residues Phe5, Leu6, Leu8, and Phe9 all interact with Pro7.