TABLE 1.
Characteristics of V. cholerae O139 strains and cholera patients studied from 1993 to 1995 and in 2002
| Parameter | Period of recruitment
|
|
|---|---|---|
| 1993-1995 | 2002 | |
| No. of patients studied | 33 | 28 |
| Age, median yra (range) | 30 (21-45) | 30 (22.5-35) |
| Gender (male:female) | 33:0b | 14:14 |
| Dehydration status (severe) (%) | 67c | 88 |
| Antibiotic used (no. of patients/total no. [%]) | Erythromycin (13/33 [39]), tetracycline (20/33 [61]) | Erythromycin (3/28 [10]), doxycycline (25/28 [90]) |
| Blood group (%) | O (71), A (15), B (14), AB (0) | O (46), A (18), B (29), AB (7) |
| Antibioticd susceptibility pattern of isolated strains | Tet, S; Strep, R; SXT, R; Nal, S | Tet, S; Strep, S; SXT, S; Nal, R |
| Lysis by phage JA1e (no. of patients/total no.) | 28/28 | 27/28 |
a
Median and range (25th to 75th centile) are shown. Clinical features were monitored at the acute phase of infection.
b
Only adult males could be enrolled in the study from 1993 to 1995.
c
Statistical significance (P < 0.001) was determined by χ2 test.
d
All strains isolated from patients were susceptible (S) to tetracycline (Tet), streptomycin (Strep), trimethoprim, and sulfamethoxazole (SXT) as well as other antibiotics (12). Only strains isolated in 2002 were resistant (R) to nalidixic acid (Nal).
e
Number positive for lysis/total number studied.