Table 2.
Differences in immunoglobulin (Ig) IgG/IgA/IgM reactivity against Epstein-Barr virus (EBV) and human herpesvirus type 6 (HHV-6) proteins and immune profiles between patients with relapsing remitting multiple sclerosis (RRMS) versus healthy controls (HC)
| Variables | HCs (n = 63) | RRMS (n = 55) | F/X2 | df | p |
|---|---|---|---|---|---|
| IgG-EBNA (peptide 386–405) | 0.619(0.115) | 1.528(0.124) | 26.720 | 4/113 | <0.0001 |
| IgM-EBNA (386–405) | 0.298(0.029) | 0.580 (0.031) | 42.120 | 4/113 | <0.0001 |
| IgA-EBNA (386–405) | 0.290 (0.026) | 0.527(0.028) | 35.210 | 4/113 | <0.0001 |
| IgG-EBV-dUTPase (243–268) | 0.836(0.098) | 1.927(0.105) | 53.964 | 4/113 | <0.0001 |
| IgM-EBV-dUTPase (243–268) | 0.609(0.061) | 1.234(0.066) | 44.831 | 4/113 | <0.0001 |
| IgA-EBV-dUTPase (243–268) | 0.511(0.076) | 1.367(0.081) | 55.131 | 4/113 | <0.0001 |
| IgG-HHV-6-dUTPase (300–322) | 0.307(0.036) | 0.739(0.038) | 62.764 | 4/113 | <0.0001 |
| IgM-HHV-6-dUTPase (300–322) | 0.326(0.032) | 0.694(0.035) | 55.459 | 4/113 | <0.0001 |
| IgA-HHV-6-dUTPase (300–322) | 0.312(0.032) | 0.628(0.034) | 43.104 | 4/113 | <0.0001 |
| M1 macrophage (z scores) | −0.573(0.112) | 0.573(0.112) | 8.161 | 4/105 | 0.005 |
| Th1 (z scores) | −0.280(0.134) | 0.280(0.134) | 67.938 | 4/105 | <0.0001 |
| Th17 (z scores) | −0.652(0.108) | 0.652(0.108) | 53.600 | 4/105 | <0.0001 |
| Chemokines (z scores) | −0.607 (0.113) | 0.607(0.113) | 61.870 | 4/105 | <0.0001 |
| GFs (z scores) | −0.630(0.109) | 0.630(0.109) | 58.254 | 4/105 | <0.0001 |
| IRS (z scores) | −0.621(0.111) | 0.621(0.111) | 152.375 | 4/105 | <0.0001 |
| CIRS (z scores) | −0.790(0.087) | 0.790(0.087) | 152.438 | 4/105 | <0.0001 |
| IRS+CIRS (z scores) | −0.793(0.088) | 0.793(0.088) | 8.161 | 4/105 | 0.005 |
Ig, Immunoglobulin; EBNA, EBV nuclear antigen; dUTPase, deoxyuridine-triphosphatase; HHV-6, human herpesvirus 6; EBV, Epstein-Barr virus; M1, macrophage M1; Th, T helper; GFs, growth factors; IRS, immune response system; CIRS, compensatory immune response system; IRS+CIRS, combined index of IRS and CIRS activation.