Table 5.
Results of multiple regression analysis with the Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Severity Score (MSSS) as dependent variables
| Dependent variables | Explanatory variables | Coefficients of input variables |
Model statistics |
|||||
|---|---|---|---|---|---|---|---|---|
| β | t | p | R2 | F | df | p | ||
| #1. EDSS | Model | 0.654 | 71.98 | 3/114 | <0.001 | |||
| IgG-HHV-6-dUTPase | 0.547 | 7.73 | <0.001 | |||||
| IgM-HHV-6-dUTPase | 0.295 | 4.21 | <0.001 | |||||
| Age | −0.142 | −2.51 | 0.013 | |||||
| #2. EDSS | Model | 0.776 | 72.20 | 5/104 | <0.001 | |||
| IRS+CIRS | 0.448 | 7.45 | <0.001 | |||||
| IgG-HHV-6-dUTPase | 0.351 | 5.50 | <0.001 | |||||
| IgM-HHV-6-dUTPase | 0.182 | 3.05 | 0.003 | |||||
| Age | −0.118 | −2.45 | 0.016 | |||||
| Sex | −0.111 | −2.39 | 0.019 | |||||
| #3. MSSS | Model | 0.521 | 22.56 | 3/114 | <0.001 | |||
| IgG-HHV-6-dUTPase | 0.497 | 6.62 | <0.001 | |||||
| IgM-EBV-dUTPase | 0.306 | 4.13 | <0.001 | |||||
| Age | −0.142 | −2.28 | 0.024 | |||||
| #4. MSSS | Model | 0.646 | 47.85 | 4/105 | <0.001 | |||
| IgG-HHV-6-dUTPase | 0.268 | 3.10 | 0.003 | |||||
| IRS+CIRS | 0.388 | 5.33 | <0.001 | |||||
| IgA-HHV-6-dUTPase | 0.252 | 3.31 | 0.001 | |||||
| Age | −0.130 | −2.16 | 0.033 | |||||
| #5 EDSS (in patients) | Model | 0.083 | 4.82 | 1/53 | 0.033 | |||
| IgM-EBV-dUTPase | 0.289 | 2.20 | 0.033 | |||||
| #6 MSSS (in patients) | Model | 0.205 | 13.64 | 1/53 | 0.001 | |||
| IgA-HHV-6-DUTPase | 0.452 | 3.693 | 0.001 | |||||
| #7 IgA-IgM dUTPase (in patients) | Model | 0.185 | 5.914 | 2/52 | 0.005 | |||
| DOI | −0.354 | −2.739 | 0.008 | |||||
| Age | 0.347 | 2.687 | 0.010 | |||||
Ig, Immunoglobulin; dUTPase, deoxyuridine-triphosphatase; HHV-6, Human herpesvirus 6; EBV, Epstein-Barr virus; DOI, duration of illness; IRS, immune response system; CIRS, compensatory immunoregulatory system; IgA+IgM dUTPase, sum of z scores of IgM and IgA to EBV and HHV-6-dUTPases.