Table 3.
Summary of the effect of geroprotectors on AMPK and NRF2.
| Geroprotector | Model organism | Tissue | Target | Effect on target | Reference |
|---|---|---|---|---|---|
| Aronia melanocarpa polysaccharide | Mus musculus | Brain | AMPK | ↑ levels | [190] |
| NRF2 | ↑ nucleus levels | ||||
| 2′-Fucosyllactose | Mus musculus | Colon | (p)AMPK | ↑ levels | [191] |
| NRF2 | ↑ levels | ||||
| Resveratrol | Mus musculus | Kidney | AMPK | ↑ phospho-Thr172/total AMPK ratio | [192] |
| NRF2 | ↑ levels (total & nuclear) | ||||
| Mulberry leaves | Mus musculus, Homo sapiens (L01 cells) | Liver | AMPK | ↑ levels | [193] |
| NRF2 | ↑ levels (total & nuclear) | ||||
| Xiyangshen Sanqi Danshen granules | Mus musculus | Brain | AMPK | ↑ levels | [194] |
| NRF2 | ↑ nuclear/cytosolic NRF2 ratio, AMPK-dependent | ||||
| Green tea polyphenols | Caenorhabditis elegans | AMPK | No lifespan increase by green tea polyphenols upon AMPK or Nrf2 inhibition | [195] | |
| NRF2 | |||||
| Ergothioneine | Mus musculus | Brain | AMPK | ↑ levels | [196] |
| NRF2 | ↑ levels |