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Enhanced protective efficacy after immunization with codon-optimized phAg85B. Protection against M. tuberculosis in mice immunized intramuscularly three times at 3-week intervals with 100 μg of pAg85B, phAg85B, or mock vector. Mice were challenged with 500 CFU of M. tuberculosis H37Rv by inhalation and bacterial counts in lungs and spleen were determined 4 weeks after infection. Data are the means ± standard deviations of three mice. *, P < 0.05; **, P < 0.01.
