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. 2025 Jul 17;13:1617737. doi: 10.3389/fcell.2025.1617737

FIGURE 3.

Panel of eight scatter plots and bubble charts analyzing cell types and gene expression related to psoriasis. Panels A, B, C, E, F, and G show UMAP plots of cell distribution under control and imiquimod conditions, with color coding indicating various scores. Panels D and H display bubble charts depicting gene expression levels and percent expressed, with highlighted genes "Ifng" and "Eppk1" respectively.

Comprehensive scRNAseq analysis of plakin regulation in IMQ-induced murine psoriasis (A) UMAP visualization from a scRNAseq analysis, revealing 12 distinct cell clusters. (B,C) Feature plots illustrate a psoriasis module score, including the expression levels of Ifng, Il17a, Il1b, Il22, Il23a, Krt16, Krt6a, Mki67, S100a7a, S100a8, S100a9 genes. Feature plots are split by condition into (B) healthy skin and (C) imiquimod (IMQ) conditions. (D) Dot plot of psoriasis related genes split by condition. Dot size represents the expression percentage for each gene with color intensity reflecting average gene expression levels. (E) UMAP of a subset from the keratinocyte cluster, showing 4 clusters representing stages of keratinocyte differentiation. (F,G) Feature plots showing a plakin module score, including expression levels of Dsp, Dst, Eppk1, Evpl, Macf1, Plec, and Ppl genes, split by condition into (F) healthy controls and (G) imiquimod (IMQ). (H) Dot plot of epidermal plakins in the keratinocyte subset split by condition. Dot size represents the expression percentage for each gene with color intensity reflecting average gene expression levels.