FIG. 3.
The rAls1p-N vaccine induces a DTH reaction in neutropenic mice and improves their survival during subsequent hematogenously disseminated candidiasis. (A) Footpad swelling was assessed 24 h after injection of 50 μg of rAls1p-N into the footpad in BALB/c mice (n = 10 for control, n = 8 for rAls1p-N). *, P = 0.006 versus control by Wilcoxon rank sum test. (B) Survival of neutropenic BALB/c mice (n = 16 per group from two experiments) infected with 2.5 × 104 blastospores of C. albicans. *, P = 0.007 versus adjuvant control by log rank test.