Table 4.
Summary of AEs by GVS in older (≥70 years old) patients receiving olaparib plus bevacizumab.
| AEs | GVS = 0 (n = 34) |
GVS ≥ 1 (n = 48) |
| Grade ≥3 | 21 (61.8) | 35 (72.9) |
| Serious AEs | 12 (35.3) | 21 (43.8) |
| Leading to dose interruption | 17 (50.0) | 32 (66.7) |
| Leading to dose reduction | 12 (35.3) | 26 (54.2) |
| Leading to discontinuation | 10 (29.4) | 13 (27.1) |
| Leading to death | 0 (0) | 0 (0) |
Data are n (%) unless otherwise stated. Relationship to the indicated agent was assessed by the investigator. AEs were graded according to the CTCAE, version 4.03.
Abbreviations: AE, adverse event; CTCAE, National Cancer Institute Common Terminology Criteria for Adverse Events; GVS, Geriatric Vulnerability Score.