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. 2025 Jul 31;8:0798. doi: 10.34133/research.0798

Fig. 3.

Fig. 3.

The phenotypic transformation of SMCs. (A) IHC images of α-SMA from 10 to 30 weeks. As the disease progresses, the content of α-SMA in diseased area gradually decreases. (B) Comparison between the IHC images of α-SMA and Masson images. There are still a large number of muscle fibers present in the areas where the content of α-SMA is low. (C) IHC images show that the content of Col I is higher in random area (n = 5). (D) IHC images show that the content of Runx 2 is higher in random area (n = 5). The same mouse was used for each time point and IHC, with a total of 5 mice used. The significance of differences between groups was analyzed using the t test, with ***P < 0.001.