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Immune response profiles of unchallenged controls and sheep challenged orally with a tissue homogenate of M. avium subsp. paratuberculosis (JD3). (A) Mean lymphocyte transformation response following PPDj stimulation of peripheral blood mononuclear cells (PBMC). (B) IFN-γ production in PPDj-stimulated blood. (C) PPDj-specific antibody levels, as measured by ELISA. Mean data ± standard errors of the means (SEM) are shown (n = 30 challenged and 10 unchallenged animals).
