TABLE 3.
Histolopathological and microbiological status of animals challenged by different infection protocolsa
| Route of infection | Strain of organism | Treatment designation | Dose (CFU) | No. of positive animals/total no. of animals (histopathology result; culture result)
|
|||
|---|---|---|---|---|---|---|---|
| Necropsied at 7 mos | Necropsied at 12 mos | Necropsied at 14 to 16 mos | Total | ||||
| Intra tonsill | JD3 (direct tissue homogenate) | JD3-IT | 5 × 107 | 5/7, 7/7 | 1/2, 0/2 | 1/3, 1/3 | 7/12, 8/12 |
| Oral | JD3 (direct tissue homogenate) | JD3-O | 5 × 107 | 4/6, 6/6 | 1/2, 0/2 | 4/4, 2/4 | 9/12, 8/12 |
| Oral | W strain (laboratory cultured) | W-O | 1 × 109 | 1/6, 3/6 | 0/2, 0/2 | 0/4, 0/4 | 1/12, 3/12 |
a
Each group received two doses at 1 month apart. No animals had clinical disease, as measured by weight loss.